D-Alanine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- (BioDeep_00000838257)

   


代谢物信息卡片


D-Alanine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-

化学式: C43H67N13O10 (925.5133602)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(C)C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)CNC
InChI: InChI=1S/C43H67N13O10/c1-7-24(4)35(40(63)53-31(19-27-20-47-22-49-27)41(64)56-17-9-11-32(56)38(61)50-25(5)42(65)66)55-37(60)30(18-26-12-14-28(57)15-13-26)52-39(62)34(23(2)3)54-36(59)29(51-33(58)21-46-6)10-8-16-48-43(44)45/h12-15,20,22-25,29-32,34-35,46,57H,7-11,16-19,21H2,1-6H3,(H,47,49)(H,50,61)(H,51,58)(H,52,62)(H,53,63)(H,54,59)(H,55,60)(H,65,66)(H4,44,45,48)/t24-,25+,29-,30-,31-,32-,34-,35-/m0/s1

描述信息

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TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ?-arrestins while blocking G-protein signaling[1]. TRV120027?induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the?acute decompensated heart failure (ADHF) treatment[2].
TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ?-arrestins while blocking G-protein signaling[1]. TRV120027?induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the?acute decompensated heart failure (ADHF) treatment[2].

同义名列表

2 个代谢物同义名

D-Alanine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-; TRV-120027



数据库引用编号

5 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Caroline Antunes Lino, Maria Luiza Barreto-Chaves. Beta-arrestins in the context of cardiovascular diseases: Focusing on angiotensin II type 1 receptor (AT1R). Cellular signalling. 2022 04; 92(?):110253. doi: 10.1016/j.cellsig.2022.110253. [PMID: 35077849]
  • Abdolhamid Esmaeeli, Fatemeh Ebrahimi, Kaveh Tanha, Majid Assadi, Mohammad Seyedabadi. Low-dose angiotensin AT1 receptor β-arrestin-biased ligand, TRV027, protects against cisplatin-induced nephrotoxicity. Pharmacological reports : PR. 2020 Dec; 72(6):1676-1684. doi: 10.1007/s43440-020-00172-5. [PMID: 33090352]
  • Gad Cotter, Beth A Davison, Javed Butler, Sean P Collins, Justin A Ezekowitz, G Michael Felker, Gerasimos Filippatos, Phillip D Levy, Marco Metra, Piotr Ponikowski, John R Teerlink, Adriaan A Voors, Stefanie Senger, David Bharucha, Kathleen Goin, David G Soergel, Peter S Pang. Relationship between baseline systolic blood pressure and long-term outcomes in acute heart failure patients treated with TRV027: an exploratory subgroup analysis of BLAST-AHF. Clinical research in cardiology : official journal of the German Cardiac Society. 2018 Feb; 107(2):170-181. doi: 10.1007/s00392-017-1168-0. [PMID: 28986703]
  • Chun-Hua Liu, Zheng Gong, Zong-Lai Liang, Zhi-Xin Liu, Fan Yang, Yu-Jing Sun, Ming-Liang Ma, Yi-Jing Wang, Chao-Ran Ji, Yu-Hong Wang, Mei-Jie Wang, Fu-Ai Cui, Amy Lin, Wen-Shuai Zheng, Dong-Fang He, Chang-Xiu Qu, Peng Xiao, Chuan-Yong Liu, Alex R B Thomsen, Thomas Joseph Cahill, Alem W Kahsai, Fan Yi, Kun-Hong Xiao, Tian Xue, Zhuan Zhou, Xiao Yu, Jin-Peng Sun. Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Nature communications. 2017 02; 8(?):14335. doi: 10.1038/ncomms14335. [PMID: 28181498]
  • Barry Greenberg. Novel Therapies for Heart Failure　- Where Do They Stand?. Circulation journal : official journal of the Japanese Circulation Society. 2016 Aug; 80(9):1882-91. doi: 10.1253/circj.cj-16-0742. [PMID: 27545139]
  • Carla P Carneiro de Morais, Juliano Z Polidoro, Donna L Ralph, Thaissa D Pessoa, Maria Oliveira-Souza, Valério G Barauna, Nancy A Rebouças, Gerhard Malnic, Alicia A McDonough, Adriana C C Girardi. Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling. American journal of physiology. Cell physiology. 2015 Oct; 309(8):C541-50. doi: 10.1152/ajpcell.00072.2015. [PMID: 26246427]
  • David G Soergel, Ruth Ann Subach, Conrad L Cowan, Jonathan D Violin, Michael W Lark. First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of clinical pharmacology. 2013 Sep; 53(9):892-9. doi: 10.1002/jcph.111. [PMID: 23813302]
  • Guido Boerrigter, David G Soergel, Jonathan D Violin, Michael W Lark, John C Burnett. TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure. Circulation. Heart failure. 2012 Sep; 5(5):627-34. doi: 10.1161/circheartfailure.112.969220. [PMID: 22891045]
  • Guido Boerrigter, Michael W Lark, Erin J Whalen, David G Soergel, Jonathan D Violin, John C Burnett. Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure. Circulation. Heart failure. 2011 Nov; 4(6):770-8. doi: 10.1161/circheartfailure.111.962571. [PMID: 21835984]