Prajmaline (BioDeep_00000838254)

   


代谢物信息卡片


Prajmaline

化学式: C23H33N2O2+ (369.2541898)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC[N+]12C3CC(C(C1O)CC)C4C2CC5(C3N(C6=CC=CC=C65)C)C4O
InChI: InChI=1S/C23H33N2O2/c1-4-10-25-17-11-14(13(5-2)22(25)27)19-18(25)12-23(21(19)26)15-8-6-7-9-16(15)24(3)20(17)23/h6-9,13-14,17-22,26-27H,4-5,10-12H2,1-3H3/q+1/t13-,14-,17-,18-,19-,20-,21+,22+,23+,25-/m0/s1

描述信息

C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BA - Antiarrhythmics, class ia
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents

同义名列表

1 个代谢物同义名

Prajmaline



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • P Petovský, J Malý. [A case of fatal poisoning with the anti-arrhythmia agents Katen and Neo-Gilurytmal]. Soudni lekarstvi. 1997 May; 42(2):18-20. doi: NULL. [PMID: 9340789]
  • H P Breuel, H J Weimann, W Dahmen, H J Hausleiter, S Bondy. Pharmacokinetics and relative bioavailability of prajmalium bitartrate after single oral dosing. Arzneimittel-Forschung. 1991 Dec; 41(12):1222-5. doi: NULL. [PMID: 1815520]
  • R Lenzen, H Gottesbüren, F Borchard, M Wienbeck, G Strohmeyer. [Intrahepatic cholestasis and aplastic anemia following administration of prajmaline]. Klinische Wochenschrift. 1988 Mar; 66(6):264-70. doi: 10.1007/bf01748169. [PMID: 2452916]
  • E Nováková. [Detection of prajmalium bitartrate (Neo-Gilurytmal) in urine with thin layer chromatography]. Die Pharmazie. 1987 Aug; 42(8):550-1. doi: NULL. [PMID: 3432338]
  • R Padrini, D Piovan, R Moretto. Column liquid chromatographic determination of prajmalium in plasma and urine by direct sample injection. Journal of chromatography. 1987 Mar; 415(1):183-7. doi: 10.1016/s0378-4347(00)83208-9. [PMID: 3584355]
  • R Elfner, G Achtert, H J Hausleiter, A Lentz, D L Heene. Pharmacokinetics of n-propyl-ajmaline-bitartrate in elderly patients with ventricular ectopic activity. European journal of drug metabolism and pharmacokinetics. 1987 Jan; 12(1):77-82. doi: 10.1007/bf03189865. [PMID: 3609075]
  • R Elfner, W Kollmeier, A Lentz, G Achtert, I Engels, D L Heene, H J Hausleiter, E Westphal. [Dose-effect relation of N-prajmalium bitartrate with control of plasma levels]. Zeitschrift fur Kardiologie. 1986 Jul; 75(7):402-9. doi: NULL. [PMID: 2429467]
  • C Zekorn, G Achtert, H J Hausleiter, C H Moon, M Eichelbaum. Pharmacokinetics of N-propylajmaline in relation to polymorphic sparteine oxidation. Klinische Wochenschrift. 1985 Nov; 63(22):1180-6. doi: 10.1007/bf01740595. [PMID: 4079282]
  • A T Trompler, B G Woodcock, W D Bussmann. [Pharmacokinetics and Antiarrhythmic effects of Prajmalium Bitartrate]. Arzneimittel-Forschung. 1983; 33(3):436-9. doi: NULL. [PMID: 6683519]
  • B Schwartzkopff, G Schilling, H Simon. Comparison of tocainide and prajmalium bitartrate for the treatment of ventricular arrhythmias. Arzneimittel-Forschung. 1983; 33(1):153-8. doi: NULL. [PMID: 6403021]
  • H J Hausleiter, G Achtert, M A Khan, W R Kukovetz, E Beubler. [Pharmacokinetics and biotransformation of N-propylajmaline hydrogen tartrate in man]. European journal of drug metabolism and pharmacokinetics. 1982 Oct; 7(4):329-39. doi: 10.1007/bf03189637. [PMID: 7166185]
  • H H Rotmensch, A Leiser, M Dan, A Klejman, E Livni, B Ilie, G Messer, U Kadish, M Liron. Evaluation of prajmalium-induced cholestasis by immunologic tests. Archives of internal medicine. 1981 Dec; 141(13):1797-1801. doi: 10.1001/archinte.141.13.1797. [PMID: 7316626]
  • M Thoma, L Farinello, A Müller. [Gas chromatographic method for determining N-propylajmalin bitartrate in human plasma (author's transl)]. Arzneimittel-Forschung. 1981; 31(6):1020-1. doi: NULL. [PMID: 7196232]
  • H P Buscher, H Talke, H P Rademacher, U Gessner, W Oehlert, W Gerok. [Intrahepatic cholestasis due to N-propyl ajmaline]. Deutsche medizinische Wochenschrift (1946). 1976 Apr; 101(18):699-703. doi: 10.1055/s-0028-1104163. [PMID: 1261401]
  • H Henning, H M Vogel, J Ihlenfeld, K Buchegger, C J Lüders. [Liver damage due to N-propyl-ajmalin bitartrate (NPAB)]. Zeitschrift fur Gastroenterologie. 1975 Sep; 13(5):501-6. doi: NULL. [PMID: 1189511]