N,N-Dimethyl-5-({2-Methyl-6-[(5-Methylpyrazin-2-Yl)carbamoyl]-1-Benzofuran-4-Yl}oxy)pyrimidine-2-Carboxamide (BioDeep_00000838253)
代谢物信息卡片
化学式: C22H20N6O4 (432.1546)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC2=C(O1)C=C(C=C2OC3=CN=C(N=C3)C(=O)N(C)C)C(=O)NC4=NC=C(N=C4)C
InChI: InChI=1S/C22H20N6O4/c1-12-8-24-19(11-23-12)27-21(29)14-6-17-16(5-13(2)31-17)18(7-14)32-15-9-25-20(26-10-15)22(30)28(3)4/h5-11H,1-4H3,(H,24,27,29)
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Hidetaka Kamimura, Shotaro Uehara, Hiroshi Suemizu. A novel Css-MRTpo approach to simulate oral plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Jul; 50(7):761-768. doi:
10.1080/00498254.2019.1693082. [PMID: 31721621] - Hidetaka Kamimura, Satoshi Ito, Hiroyuki Chijiwa, Takeshi Okuzono, Tomohiro Ishiguro, Yosuke Yamamoto, Sho Nishinoaki, Shin-Ichi Ninomiya, Marina Mitsui, Amit S Kalgutkar, Hiroshi Yamazaki, Hiroshi Suemizu. Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 May; 47(5):382-393. doi:
10.1080/00498254.2016.1199063. [PMID: 27389028] - William S Denney, Douglas S Denham, Michael R Riggs, Neeta B Amin. Glycemic Effect and Safety of a Systemic, Partial Glucokinase Activator, PF-04937319, in Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin-A Randomized, Crossover, Active-Controlled Study.
Clinical pharmacology in drug development.
2016 Nov; 5(6):517-527. doi:
10.1002/cpdd.261. [PMID: 27870481] - N B Amin, N Aggarwal, D Pall, G Paragh, W S Denney, V Le, M Riggs, R A Calle. Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes.
Diabetes, obesity & metabolism.
2015 Aug; 17(8):751-9. doi:
10.1111/dom.12474. [PMID: 25885172] - Raman Sharma, John Litchfield, Karen Atkinson, Heather Eng, Neeta B Amin, William S Denney, John C Pettersen, Theunis C Goosen, Li Di, Esther Lee, Jeffrey A Pfefferkorn, Deepak K Dalvie, Amit S Kalgutkar. Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator.
Drug metabolism and disposition: the biological fate of chemicals.
2014 11; 42(11):1926-39. doi:
10.1124/dmd.114.060087. [PMID: 25142735]
