[1,1-Biphenyl]-4-methanamine, N-(2,3-dihydro-1H-inden-2-yl)-3,5-difluoro-3-(1H-1,2,4-triazol-5-yl)- (BioDeep_00000838241)

   


代谢物信息卡片


[1,1-Biphenyl]-4-methanamine, N-(2,3-dihydro-1H-inden-2-yl)-3,5-difluoro-3-(1H-1,2,4-triazol-5-yl)-

化学式: C24H20F2N4 (402.16559440000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(CC2=CC=CC=C21)NCC3=C(C=C(C=C3F)C4=CC(=CC=C4)C5=NC=NN5)F
InChI: InChI=1S/C24H20F2N4/c25-22-11-19(15-6-3-7-18(8-15)24-28-14-29-30-24)12-23(26)21(22)13-27-20-9-16-4-1-2-5-17(16)10-20/h1-8,11-12,14,20,27H,9-10,13H2,(H,28,29,30)

描述信息

GSK1521498 free base is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base has the potential for disorders of compulsive consumption of food, alcohol, and agents[1].

同义名列表

2 个代谢物同义名

[1,1-Biphenyl]-4-methanamine, N-(2,3-dihydro-1H-inden-2-yl)-3,5-difluoro-3-(1H-1,2,4-triazol-5-yl)-; GSK1521498 (free base)



数据库引用编号

5 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Pradeep J Nathan, Mark A Bush, Wenli X Tao, Annelize Koch, Kirsty M Davies, Kay Maltby, Barry V O'Neill, Antonella Napolitano, Andrew L Skeggs, Allison C Brooke, Duncan B Richards, Pauline M Williams, Edward T Bullmore. Multiple-dose safety, pharmacokinetics, and pharmacodynamics of the μ-opioid receptor inverse agonist GSK1521498. Journal of clinical pharmacology. 2012 Oct; 52(10):1456-67. doi: 10.1177/0091270011421785. [PMID: 22162534]
  • Pradeep J Nathan, Barry V O'Neill, Mark A Bush, Annelize Koch, Wenli X Tao, Kay Maltby, Antonella Napolitano, Allison C Brooke, Andrew L Skeggs, Craig S Herman, Andrew L Larkin, Diane M Ignar, Duncan B Richards, Pauline M Williams, Edward T Bullmore. Opioid receptor modulation of hedonic taste preference and food intake: a single-dose safety, pharmacokinetic, and pharmacodynamic investigation with GSK1521498, a novel μ-opioid receptor inverse agonist. Journal of clinical pharmacology. 2012 Apr; 52(4):464-74. doi: 10.1177/0091270011399577. [PMID: 21610207]
  • Diane M Ignar, Aaron S Goetz, Kimberly Nichols Noble, Luz Helena Carballo, Andrea E Stroup, Julie C Fisher, Joyce A Boucheron, Tracy A Brainard, Andrew L Larkin, Andrea H Epperly, Todd W Shearer, Scott D Sorensen, Jason D Speake, Jonathan D Hommel. Regulation of ingestive behaviors in the rat by GSK1521498, a novel micro-opioid receptor-selective inverse agonist. The Journal of pharmacology and experimental therapeutics. 2011 Oct; 339(1):24-34. doi: 10.1124/jpet.111.180943. [PMID: 21712426]
  • E A Rabiner, J Beaver, A Makwana, G Searle, C Long, P J Nathan, R D Newbould, J Howard, S R Miller, M A Bush, S Hill, R Reiley, J Passchier, R N Gunn, P M Matthews, E T Bullmore. Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans. Molecular psychiatry. 2011 Aug; 16(8):826-35, 785. doi: 10.1038/mp.2011.29. [PMID: 21502953]