Bms-986094 (BioDeep_00000838231)
代谢物信息卡片
化学式: C30H39N6O9P (658.2516013999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(=O)OCC(C)(C)C)NP(=O)(OCC1C(C(C(O1)N2C=NC3=C2N=C(N=C3OC)N)(C)O)O)OC4=CC=CC5=CC=CC=C54
InChI: InChI=1S/C30H39N6O9P/c1-17(26(38)42-15-29(2,3)4)35-46(40,45-20-13-9-11-18-10-7-8-12-19(18)20)43-14-21-23(37)30(5,39)27(44-21)36-16-32-22-24(36)33-28(31)34-25(22)41-6/h7-13,16-17,21,23,27,37,39H,14-15H2,1-6H3,(H,35,40)(H2,31,33,34)/t17-,21+,23+,27+,30+,46?/m0/s1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Michael Gill, Kristen Horn, James Hennan, Randy White, Denise Bounous, Shawn Clark, John R Megill, Evan Janovitz, Marc Davies, Thomas Sanderson, Michael Graziano. From the Cover: Investigative Nonclinical Cardiovascular Safety and Toxicology Studies with BMS-986094, an NS5b RNA-Dependent RNA Polymerase Inhibitor.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 02; 155(2):348-362. doi:
10.1093/toxsci/kfw211. [PMID: 27864544] - Bethany R Baumgart, Faye Wang, Jae Kwagh, Chris Storck, Catherine Euler, Megan Fuller, Damir Simic, Suresh Sharma, Jamie J Arnold, Craig E Cameron, Terry R Van Vleet, Oliver Flint, Roderick T Bunch, Marc H Davies, Michael J Graziano, Thomas P Sanderson. Effects of BMS-986094, a Guanosine Nucleotide Analogue, on Mitochondrial DNA Synthesis and Function.
Toxicological sciences : an official journal of the Society of Toxicology.
2016 10; 153(2):396-408. doi:
10.1093/toxsci/kfw135. [PMID: 27466212] - Ang Liu, John Lute, Huidong Gu, Bonnie Wang, Kevin J Trouba, Mark E Arnold, Anne-Françoise Aubry, Jian Wang. Challenges and solutions in the bioanalysis of BMS-986094 and its metabolites including a highly polar, active nucleoside triphosphate in plasma and tissues using LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Sep; 1000(?):29-40. doi:
10.1016/j.jchromb.2015.07.006. [PMID: 26209768] - John H Vernachio, Blair Bleiman, K Dawn Bryant, Stanley Chamberlain, Damound Hunley, Jeff Hutchins, Brenda Ames, Elena Gorovits, Babita Ganguly, Andrea Hall, Alexander Kolykhalov, Yule Liu, Jerry Muhammad, Nicholas Raja, C Robin Walters, Jin Wang, Karen Williams, Joseph M Patti, Geoffrey Henson, Karolina Madela, Mohamed Aljarah, Arnaud Gilles, Christopher McGuigan. INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.
Antimicrobial agents and chemotherapy.
2011 May; 55(5):1843-51. doi:
10.1128/aac.01335-10. [PMID: 21357300]