(S)-2-Methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine (BioDeep_00000838227)
代谢物信息卡片
化学式: C16H21N3O2S (319.1354)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CNCCCN1S(=O)(=O)C2=CC=CC3=C2C(=CN=C3)C
InChI: InChI=1S/C16H21N3O2S/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3/t13-/m0/s1
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:88220
- PubChem: 448043
- DrugBank: DB07876
- ChEMBL: CHEMBL406821
- CAS: 451462-58-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Giulia Stefania Tavanti, Chiara Verdelli, Annamaria Morotti, Paola Maroni, Vito Guarnieri, Alfredo Scillitani, Rosamaria Silipigni, Silvana Guerneri, Riccardo Maggiore, Gilberto Mari, Leonardo Vicentini, Paolo Dalino Ciaramella, Valentina Vaira, Sabrina Corbetta. Yes-Associated Protein 1 Is a Novel Calcium Sensing Receptor Target in Human Parathyroid Tumors.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22042016. [PMID: 33670622] - Jing Zhang, Shenqiu Zhang, Qiong Shi, Thaddeus D Allen, Fengming You, Dun Yang. A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil.
PloS one.
2021; 16(3):e0248355. doi:
10.1371/journal.pone.0248355. [PMID: 33760847] - Duy Trong Vien Diep, Kyungki Hong, Triyeng Khun, Mei Zheng, Asad Ul-Haq, Hee-Sook Jun, Young-Bum Kim, Kwang-Hoon Chun. Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells.
Scientific reports.
2018 02; 8(1):2477. doi:
10.1038/s41598-018-20821-3. [PMID: 29410516] - Lisa Jolly, Anastasios Stavrou, Gilles Vanderstoken, Victoria A Meliopoulos, Anthony Habgood, Amanda L Tatler, Joanne Porte, Alan Knox, Paul Weinreb, Shelia Violette, Tracy Hussell, Martin Kolb, Martin R Stampfli, Stacey Schultz-Cherry, Gisli Jenkins. Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation.
The Journal of biological chemistry.
2014 Dec; 289(51):35246-63. doi:
10.1074/jbc.m114.582262. [PMID: 25339175] - Susanne Lutz, Marion Mohl, Julia Rauch, Pamina Weber, Thomas Wieland. RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase Iα.
Cellular signalling.
2013 Mar; 25(3):630-8. doi:
10.1016/j.cellsig.2012.11.016. [PMID: 23195829] - Jiping Wang, Hongxia Liu, Bo Chen, Qiang Li, Xuliang Huang, Liqun Wang, Xiaohua Guo, Qiaobing Huang. RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response.
Cardiovascular diabetology.
2012 Jan; 11(?):7. doi:
10.1186/1475-2840-11-7. [PMID: 22251897] - Paul A J Krijnen, Jessica A Sipkens, Johan W Molling, Jan A Rauwerda, Coen D A Stehouwer, Alice Muller, Walter J Paulus, Geerten P van Nieuw Amerongen, C Erik Hack, Arthur J Verhoeven, Victor W M van Hinsbergh, Hans W M Niessen. Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase.
Journal of molecular and cellular cardiology.
2010 Nov; 49(5):781-90. doi:
10.1016/j.yjmcc.2010.07.017. [PMID: 20691698] - Kai M Schmidt-Ott. ROCK inhibition facilitates tissue reconstitution from embryonic kidney cell suspensions.
Kidney international.
2010 Mar; 77(5):387-9. doi:
10.1038/ki.2009.488. [PMID: 20150939] - Ji-Ping Wang, Xiao-Hua Guo, Ling-Jun Wang, Qiang Li, Bo Chen, Wei Wu, Xu-Liang Huang, Qiao-Bing Huang. [Effects of Rho/ROCK signal pathway on AGEs-induced morphological and functional changes in human dermal microvascular endothelial cells.].
Sheng li xue bao : [Acta physiologica Sinica].
2009 Apr; 61(2):132-8. doi:
NULL. [PMID: 19377824] - Laurent Bultot, Sandrine Horman, Dietbert Neumann, Michael P Walsh, Louis Hue, Mark H Rider. Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes.
FEBS letters.
2009 Jan; 583(1):25-8. doi:
10.1016/j.febslet.2008.11.022. [PMID: 19061891] - Aysegül Tura, Frank Schuettauf, Philippe P Monnier, Karl U Bartz-Schmidt, Sigrid Henke-Fahle. Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina.
Investigative ophthalmology & visual science.
2009 Jan; 50(1):452-61. doi:
10.1167/iovs.08-1973. [PMID: 18757509] - P Vasantha Rao, Peifeng Deng, Yasuharu Sasaki, David L Epstein. Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility.
Experimental eye research.
2005 Feb; 80(2):197-206. doi:
10.1016/j.exer.2004.08.029. [PMID: 15670798]
