Monoxerutin (BioDeep_00000838200)
代谢物信息卡片
Monoxerutin
化学式: C29H34O17 (654.1795914)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)OCCO)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O
InChI: InChI=1S/C29H34O17/c1-10-19(34)22(37)24(39)28(43-10)42-9-17-20(35)23(38)25(40)29(45-17)46-27-21(36)18-15(33)7-12(41-5-4-30)8-16(18)44-26(27)11-2-3-13(31)14(32)6-11/h2-3,6-8,10,17,19-20,22-25,28-35,37-40H,4-5,9H2,1H3/t10-,17+,19-,20+,22+,23-,24+,25+,28+,29-/m0/s1
描述信息
C - Cardiovascular system > C05 - Vasoprotectives > C05C - Capillary stabilizing agents > C05CA - Bioflavonoids
D006401 - Hematologic Agents > D000925 - Anticoagulants
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:134704
- PubChem: 9852585
- DrugBank: DB13764
- ChEMBL: CHEMBL3527416
- CAS: 23869-24-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ahmet Güzel, Alper Özorak, Taylan Oksay, Sefa Alperen Öztürk, Kemal Kürşat Bozkurt, Sedat Yunusoğlu, Efkan Uz, Abdulhadi Cihangir Uğuz, Pınar Aslan Koşar. The efficiency of oxerutin on apoptosis and kidney function in rats with renal ischemia reperfusion injury.
Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES.
2022 Mar; 28(3):344-351. doi:
10.14744/tjtes.2021.15740. [PMID: 35485553] - Hany H Arab, Sarah A Abd El-Aal, Ahmed H Eid, El-Shaimaa A Arafa, Ayman M Mahmoud, Ahmed M Ashour. Targeting inflammation, autophagy, and apoptosis by troxerutin attenuates methotrexate-induced renal injury in rats.
International immunopharmacology.
2022 Feb; 103(?):108284. doi:
10.1016/j.intimp.2021.108284. [PMID: 34953450] - Marco Bagnati, Chiara Puricelli, Giulia Bauce, Matteo Basile, Barbara Grigollo, Flavia Prodam, Umberto Dianzani, Giorgio Bellomo, Roberta Rolla. Short-Term Effects of Supplemental L-Arginine, Diosmin, Troxerutin, and Hesperidin in Diabetic Patients: A Pilot Study.
BioMed research international.
2021; 2021(?):3508281. doi:
10.1155/2021/3508281. [PMID: 34901269] - Ayat Kaeidi, Zahra Taghipour, Mohammad Allahtavakoli, Iman Fatemi, Elham Hakimizadeh, Jalal Hassanshahi. Ameliorating effect of troxerutin in unilateral ureteral obstruction induced renal oxidative stress, inflammation, and apoptosis in male rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 05; 393(5):879-888. doi:
10.1007/s00210-019-01801-4. [PMID: 31900517] - Afsaneh Ghadiri, Fariba Mirzaei Bavil, Gholam Reza Hamidian, Hajar Oghbaei, Zohreh Zavvari Oskuye, Mahdi Ahmadi, Rana Keyhanmanesh. Can troxerutin pretreatment prevent testicular complications in prepubertal diabetic male rats?.
Endocrine regulations.
2020 Apr; 54(2):85-95. doi:
10.2478/enr-2020-0011. [PMID: 32597159] - Xuan Yang, Wentao Xu, Kunlun Huang, Boyang Zhang, Haomiao Wang, Xueqin Zhang, Lijing Gong, Yunbo Luo, Xiaoyun He. Precision toxicology shows that troxerutin alleviates ochratoxin A-induced renal lipotoxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 02; 33(2):2212-2227. doi:
10.1096/fj.201800742r. [PMID: 30247986] - Fereshteh Dehnamaki, Akbar Karimi, Ali Asghar Pilevarian, Iman Fatemi, Elham Hakimizadeh, Ayat Kaeidi, Mohammad Allahtavakoli, Mohammad Reza Rahmani, Morteza Khademalhosseini, Gholamreza Bazmandegan. Treatment with troxerutin protects against cisplatin-induced kidney injury in mice.
Acta chirurgica Belgica.
2019 Feb; 119(1):31-37. doi:
10.1080/00015458.2018.1455418. [PMID: 29653502] - Boobalan Raja, Dhanasekaran Saranya, Rajendran Prabhu. Role of flavonoid troxerutin on blood pressure, oxidative stress and regulation of lipid metabolism.
Frontiers in bioscience (Elite edition).
2019 01; 11(1):121-129. doi:
10.2741/e851. [PMID: 30468643] - Hana Malinska, Martina Hüttl, Olena Oliyarnyk, Irena Markova, Martin Poruba, Zuzana Racova, Ludmila Kazdova, Rostislav Vecera. Beneficial effects of troxerutin on metabolic disorders in non-obese model of metabolic syndrome.
PloS one.
2019; 14(8):e0220377. doi:
10.1371/journal.pone.0220377. [PMID: 31404079] - Samir A Salama, Hany H Arab, Ibrahim A Maghrabi. Troxerutin down-regulates KIM-1, modulates p38 MAPK signaling, and enhances renal regenerative capacity in a rat model of gentamycin-induced acute kidney injury.
Food & function.
2018 Dec; 9(12):6632-6642. doi:
10.1039/c8fo01086b. [PMID: 30511081] - Qun Shan, Gui-Hong Zheng, Xin-Rui Han, Xin Wen, Shan Wang, Meng-Qiu Li, Juan Zhuang, Zi-Feng Zhang, Bin Hu, Yanqiu Zhang, Yuan-Lin Zheng. Troxerutin Protects Kidney Tissue against BDE-47-Induced Inflammatory Damage through CXCR4-TXNIP/NLRP3 Signaling.
Oxidative medicine and cellular longevity.
2018; 2018(?):9865495. doi:
10.1155/2018/9865495. [PMID: 29849929] - Perumal Elangovan, Ramalingam Ramakrishnan, Kasinathan Amudha, Abdulkadhar Mohamed Jalaludeen, Gunasekaran Karuna Sagaran, Frankline Rajan Babu, Leelavinothan Pari. Beneficial Protective Effect of Troxerutin on Nickel-Induced Renal Dysfunction in Wistar Rats.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
2018; 37(1):1-14. doi:
10.1615/jenvironpatholtoxicoloncol.2017025087. [PMID: 29772996] - Yongzhi Yu, Guanzhong Zheng. Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes.
Molecular medicine reports.
2017 Jun; 15(6):3473-3478. doi:
10.3892/mmr.2017.6456. [PMID: 28440404] - Liliang Shu, Wanzhe Zhang, Chen Huang, Gongcheng Huang, Gang Su. Troxerutin Protects Against Myocardial Ischemia/Reperfusion Injury Via Pi3k/Akt Pathway in Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 44(5):1939-1948. doi:
10.1159/000485884. [PMID: 29241161] - Qun Shan, Juan Zhuang, Guihong Zheng, Zifeng Zhang, Yanqiu Zhang, Jun Lu, Yuanlin Zheng. Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity.
Oxidative medicine and cellular longevity.
2017; 2017(?):6034692. doi:
10.1155/2017/6034692. [PMID: 29163754] - Man Xu, Qing Yu, Qianru Zhao, Wei Chen, Yuanjie Lin, Yong Jin. Development and in vitro-in vivo evaluation of a water-in-oil microemulsion formulation for the oral delivery of troxerutin.
Drug development and industrial pharmacy.
2016; 42(2):280-7. doi:
10.3109/03639045.2015.1047849. [PMID: 26165244] - Sathish Sampath, Balasubramanian Karundevi. Effect of troxerutin on insulin signaling molecules in the gastrocnemius muscle of high fat and sucrose-induced type-2 diabetic adult male rat.
Molecular and cellular biochemistry.
2014 Oct; 395(1-2):11-27. doi:
10.1007/s11010-014-2107-2. [PMID: 24880482] - Rajagopalan Geetha, Baskaran Yogalakshmi, S Sreeja, K Bhavani, Carani Venkatraman Anuradha. Troxerutin suppresses lipid abnormalities in the heart of high-fat-high-fructose diet-fed mice.
Molecular and cellular biochemistry.
2014 Feb; 387(1-2):123-34. doi:
10.1007/s11010-013-1877-2. [PMID: 24173620] - Hilde Jacobs, Mohamed Moalin, Aalt Bast, Wim J F van der Vijgh, Guido R M M Haenen. An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network.
PloS one.
2010 Nov; 5(11):e13880. doi:
10.1371/journal.pone.0013880. [PMID: 21079733] - Chan-Min Liu, Jie-Qiong Ma, Yao Lou. Chronic administration of troxerutin protects mouse kidney against D-galactose-induced oxidative DNA damage.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Oct; 48(10):2809-17. doi:
10.1016/j.fct.2010.07.011. [PMID: 20633594] - Zi-feng Zhang, Shao-hua Fan, Yuan-lin Zheng, Jun Lu, Dong-mei Wu, Qun Shan, Bin Hu. Troxerutin protects the mouse liver against oxidative stress-mediated injury induced by D-galactose.
Journal of agricultural and food chemistry.
2009 Sep; 57(17):7731-6. doi:
10.1021/jf9012357. [PMID: 19722705] - Shao-Hua Fan, Zi-Feng Zhang, Yuan-Lin Zheng, Jun Lu, Dong-Mei Wu, Qun Shan, Bin Hu, Yan-Yan Wang. Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation.
International immunopharmacology.
2009 Jan; 9(1):91-6. doi:
10.1016/j.intimp.2008.10.008. [PMID: 19000936] - Gong-Jun Yang, Ping Liu, Xi-Long Qu, Min-Juan Xu, Qi-Shu Qu, Cheng-Yin Wang, Xiao-Ya Hu, Zhi-Yue Wang. The simultaneous separation and determination of six flavonoids and troxerutin in rat urine and chicken plasma by reversed-phase high-performance liquid chromatography with ultraviolet-visible detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Sep; 856(1-2):222-8. doi:
10.1016/j.jchromb.2007.06.002. [PMID: 17588830] - Fei Liu, Yu Xu, Lei Rui, Shu Gao, Haijun Dong, Qingxiang Guo. Liquid chromatography/tandem mass spectrometry assay for the quantification of troxerutin in human plasma.
Rapid communications in mass spectrometry : RCM.
2006; 20(23):3522-6. doi:
10.1002/rcm.2764. [PMID: 17072901] - Anna Lisa Furfaro, Stefano Menini, Stefania Patriarca, Carlo Pesce, Patrizio Odetti, Damiano Cottalasso, Umberto M Marinari, M Adelaide Pronzato, Nicola Traverso. HNE-dependent molecular damage in diabetic nephropathy and its possible prevention by N-acetyl-cysteine and oxerutin.
BioFactors (Oxford, England).
2005; 24(1-4):291-8. doi:
10.1002/biof.5520240134. [PMID: 16403990] - Miriam Alvarez-Guerra, Patrick Hannaert, Hamida Hider, Carlo Chiavaroli, Ricardo P Garay. Vascular permeabilization by intravenous arachidonate in the rat peritoneal cavity: antagonism by antioxidants.
European journal of pharmacology.
2003 Apr; 466(1-2):199-205. doi:
10.1016/s0014-2999(03)01544-9. [PMID: 12679157] - Patrick Hannaert, Miriam Alvarez-Guerra, Hamida Hider, Carlo Chiavaroli, Ricardo P Garay. Vascular permeabilization by intravenous arachidonate in the rat peritoneal cavity: antagonism by ethamsylate.
European journal of pharmacology.
2003 Apr; 466(1-2):207-12. doi:
10.1016/s0014-2999(03)01545-0. [PMID: 12679158] - Patrizio Odetti, Carlo Pesce, Nicola Traverso, Stefano Menini, Elena Pesce Maineri, Luana Cosso, Sabina Valentini, Stefania Patriarca, Damiano Cottalasso, Umberto M Marinari, Maria Adelaide Pronzato. Comparative trial of N-acetyl-cysteine, taurine, and oxerutin on skin and kidney damage in long-term experimental diabetes.
Diabetes.
2003 Feb; 52(2):499-505. doi:
10.2337/diabetes.52.2.499. [PMID: 12540627] - J-L Kienzler, D Sallin, M-H Schifflers, A Ghika. Pharmacokinetics of mono-3'- and mono-4'-0-(beta-hydroxyethyl)-rutoside derivatives, after single doses of Venoruton powder in healthy volunteers.
European journal of clinical pharmacology.
2002 Sep; 58(6):395-402. doi:
10.1007/s00228-002-0472-3. [PMID: 12242598] - M R Cesarone, L Incandela, M T DeSanctis, G Belcaro, M Dugall, G Acerbi. Variations in plasma free radicals in patients with venous hypertension with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a clinical, prospective, placebo-controlled, randomized trial.
Journal of cardiovascular pharmacology and therapeutics.
2002 Jan; 7 Suppl 1(?):S25-8. doi:
10.1177/107424840200700107. [PMID: 12011970] - M Białecka. [The effect of bioflavonoids and lecithin on the course of experimental atherosclerosis in rabbits].
Annales Academiae Medicae Stetinensis.
1997; 43(?):41-56. doi:
. [PMID: 9471922] - K Krupiński, J Giedrojć, M Bielawiec. Effect of troxerutin on laser-induced thrombus formation in rat mesenteric vessels, coagulation parameters and platelet function.
Polish journal of pharmacology.
1996 May; 48(3):335-9. doi:
NULL. [PMID: 9112673] - A Auteri, A L Pasqui, F Bruni, M Di Renzo, G Bova, C Chiarion, J Delchambre. Pharmacodynamics and pharmacokinetics of Veliten (rutine, alpha-tocopherol and ascorbic acid) in patients with chronic venous insufficiency.
International journal of clinical pharmacology research.
1994; 14(3):95-100. doi:
NULL. [PMID: 7883390] - E Vicaut, X Hou, L Decuypère, A Taccoen, M Duvelleroy. Red blood cell aggregation and microcirculation in rat cremaster muscle.
International journal of microcirculation, clinical and experimental.
1994 Jan; 14(1-2):14-21. doi:
10.1159/000178201. [PMID: 7525499] - B Szamer. [Diffusion of lipid fractions through the barrier of cantharidin blisters in hyperlipidemias under conditions of clofibrate and rutinosid interaction].
Annales Academiae Medicae Stetinensis.
1993; 39(?):87-101. doi:
NULL. [PMID: 8154625] - A J Olszewski. Homocysteine content of plasma in ischemic heart disease, the reducing effect of pyridoxine, folate, cobalamin, choline, riboflavin and troxerutin. Correction of a calculation error.
Atherosclerosis.
1991 May; 88(1):97-8. doi:
10.1016/0021-9150(91)90262-2. [PMID: 1878015] - A Auteri, P Blardi, C Frigerio, L de Lillo, T di Perri. Pharmacodynamics of troxerutine in patients with chronic venous insufficiency: correlations with plasma drug levels.
International journal of clinical pharmacology research.
1990; 10(4):235-41. doi:
NULL. [PMID: 2079382] - A J Olszewski, W B Szostak, M Bialkowska, S Rudnicki, K S McCully. Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis.
Atherosclerosis.
1989 Jan; 75(1):1-6. doi:
10.1016/0021-9150(89)90200-1. [PMID: 2930611] - J M Bull, F R Strebel, B A Sunderland, R E Bulger, M Edwards, Z H Siddik, R A Newman. o-(beta-Hydroxyethyl)-rutoside-mediated protection of renal injury associated with cis-diamminedichloroplatinum(II)/hyperthermia treatment.
Cancer research.
1988 Apr; 48(8):2239-44. doi:
NULL. [PMID: 3349489] - G Gallasch, C Dörfer, T Schmitt, A Stage. [Efficacy of troxerutin on the flow properties of blood under defined conditions of circulation. A double-blind study of patients with diabetic retinopathy and arteriosclerotic retinopathy].
Klinische Monatsblatter fur Augenheilkunde.
1985 Jul; 187(1):30-5. doi:
10.1055/s-2008-1050983. [PMID: 3906246] - O P Gulati, H Nordmann, A Aellig, M F Maignan, J McGinness. Protective effects of O-(beta-hydroxyethyl)-rutosides (HR) against adriamycin-induced toxicity in rats.
Archives internationales de pharmacodynamie et de therapie.
1985 Feb; 273(2):323-34. doi:
NULL. [PMID: 4004421] - H Lukjan, D Rość, R Chyzy, A Bodzenta, A Szpak. The effect of HR (O-Beta-Hydroxyethylo-Rutoside, Venoruton) on the deformability of erythrocytes in patients with arteriosclerosis obliterans of lower limbs.
Folia haematologica (Leipzig, Germany : 1928).
1985; 112(1):191-6. doi:
NULL. [PMID: 2581865] - P Dittrich, J Ostrowski, E Beubler, E Schraven, W Kukovetz. [HPLC determination of troxerutin in plasma and urine following oral administration in man].
Arzneimittel-Forschung.
1985; 35(4):765-7. doi:
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Biulleten' eksperimental'noi biologii i meditsiny.
1982 Mar; 93(3):119-22. doi:
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