Silatecan (BioDeep_00000838167)
代谢物信息卡片
Silatecan
化学式: C26H30N2O5Si (478.192389)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=C(C=CC(=C5)O)N=C4C3=C2)[Si](C)(C)C(C)(C)C)O
InChI: InChI=1S/C26H30N2O5Si/c1-7-26(32)18-11-20-21-16(12-28(20)23(30)17(18)13-33-24(26)31)22(34(5,6)25(2,3)4)15-10-14(29)8-9-19(15)27-21/h8-11,29,32H,7,12-13H2,1-6H3/t26-/m0/s1
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fei Tang, Eleftheria Tsakalozou, Susanne M Arnold, Chee M Ng, Markos Leggas. Population pharmacokinetic analysis of AR-67, a lactone stable camptothecin analogue, in cancer patients with solid tumors.
Investigational new drugs.
2019 12; 37(6):1218-1230. doi:
10.1007/s10637-019-00744-0. [PMID: 30820810] - Xiaoxi Liu, Eyob Adane, Fei Tang, Markos Leggas. Pharmacokinetic modeling of the blood-stable camptothecin analog AR-67 in two different formulations.
Biopharmaceutics & drug disposition.
2019 Sep; 40(8):265-275. doi:
10.1002/bdd.2199. [PMID: 31292985] - Eleftheria Tsakalozou, Eyob D Adane, Yali Liang, Susanne M Arnold, Markos Leggas. Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans.
Cancer chemotherapy and pharmacology.
2014 Jul; 74(1):45-54. doi:
10.1007/s00280-014-2472-2. [PMID: 24807458] - Sweta Modi, Tian-Xiang Xiang, Bradley D Anderson. Enhanced active liposomal loading of a poorly soluble ionizable drug using supersaturated drug solutions.
Journal of controlled release : official journal of the Controlled Release Society.
2012 Sep; 162(2):330-9. doi:
10.1016/j.jconrel.2012.07.001. [PMID: 22800581] - Jamie Horn, Marta Milewska, Susanne M Arnold, Markos Leggas. Metabolic pathways of the camptothecin analog AR-67.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Apr; 39(4):683-92. doi:
10.1124/dmd.110.037390. [PMID: 21189330] - Teng-Kuang Yeh, Chien-Ming Li, Ching-Ping Chen, Jiuun-Jye Chuu, Chen-Lung Huang, Hsin-Sheng Wang, Chien-Chang Shen, Tien-Yi Lee, Chi-Yen Chang, Chung-Ming Chang, Yu-Sheng Chao, Chin-Tarng Lin, Jang-Yang Chang, Chiung-Tong Chen. Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91.
Pharmacological research.
2010 Feb; 61(2):108-15. doi:
10.1016/j.phrs.2009.07.005. [PMID: 19643180] - Susanne M Arnold, John J Rinehart, Eleftheria Tsakalozou, John R Eckardt, Scott Z Fields, Brent J Shelton, Philip A DeSimone, Bryan K Kee, Jeffrey A Moscow, Markos Leggas. A phase I study of 7-t-butyldimethylsilyl-10-hydroxycamptothecin in adult patients with refractory or metastatic solid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2010 Jan; 16(2):673-80. doi:
10.1158/1078-0432.ccr-09-2429. [PMID: 20068096] - Stefan Kruszewski, Blanka Ziomkowska, Michał Cyrankiewicz, Tomasz Wybranowski. The comparison of biophysical properties of DB-67 and its ester DB-67-4ABTFA determined by fluorescence spectroscopy methods.
Bio Systems.
2008 Dec; 94(3):270-5. doi:
10.1016/j.biosystems.2008.05.035. [PMID: 18718502] - Vijay Joguparthi, Bradley D Anderson. Effect of cyclodextrin complexation on the liposome permeability of a model hydrophobic weak Acid.
Pharmaceutical research.
2008 Nov; 25(11):2505-15. doi:
10.1007/s11095-008-9664-6. [PMID: 18642063] - William C Zamboni, Laura L Jung, Sandra Strychor, Erin Joseph, Beth A Zamboni, Sarah A Fetterman, Brian J Sidone, Thomas G Burke, Dennis P Curran, Julie L Eiseman. Plasma and tissue disposition of non-liposomal DB-67 and liposomal DB-67 in C.B-17 SCID mice.
Investigational new drugs.
2008 Oct; 26(5):399-406. doi:
10.1007/s10637-007-9109-9. [PMID: 18246299] - Vijay Joguparthi, Shaoxin Feng, Bradley D Anderson. Determination of intraliposomal pH and its effect on membrane partitioning and passive loading of a hydrophobic camptothecin, DB-67.
International journal of pharmaceutics.
2008 Mar; 352(1-2):17-28. doi:
10.1016/j.ijpharm.2007.10.003. [PMID: 18065174] - Vijay Joguparthi, Tian-Xiang Xiang, Bradley D Anderson. Liposome transport of hydrophobic drugs: gel phase lipid bilayer permeability and partitioning of the lactone form of a hydrophobic camptothecin, DB-67.
Journal of pharmaceutical sciences.
2008 Jan; 97(1):400-20. doi:
10.1002/jps.21125. [PMID: 17879989] - Blanka Ziomkowska, Michał Cyrankiewicz, Stefan Kruszewski. Hydroxycamptothecin deactivation rates and binding to model membranes and HSA determined by fluorescence spectra analysis.
Combinatorial chemistry & high throughput screening.
2007 Jul; 10(6):459-65. doi:
10.2174/138620707781996394. [PMID: 17896941] - Blanka Ziomkowska, Michal Cyrankiewicz, Stefan Kruszewski. Determination of hydroxycamptothecin affinities to albumin and membranes by steady-state fluorescence anisotropy measurements.
Combinatorial chemistry & high throughput screening.
2007 Jul; 10(6):486-92. doi:
10.2174/138620707781996420. [PMID: 17896945] - Jamie Horn, Sherri L Jordan, Lin Song, Michael J Roberts, Bradley D Anderson, Markos Leggas. Validation of an HPLC method for analysis of DB-67 and its water soluble prodrug in mouse plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Nov; 844(1):15-22. doi:
10.1016/j.jchromb.2006.06.022. [PMID: 16860004] - Tian-Xiang Xiang, Zhi-Qiang Jiang, Lin Song, Bradley D Anderson. Molecular dynamics simulations and experimental studies of binding and mobility of 7-tert-butyldimethylsilyl-10-hydroxycamptothecin and its 20(S)-4-aminobutyrate ester in DMPC membranes.
Molecular pharmaceutics.
2006 Sep; 3(5):589-600. doi:
10.1021/mp0600081. [PMID: 17009858] - D Bom, D P Curran, J Zhang, S G Zimmer, R Bevins, S Kruszewski, J N Howe, A Bingcang, L J Latus, T G Burke. The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity.
Journal of controlled release : official journal of the Controlled Release Society.
2001 Jul; 74(1-3):325-33. doi:
10.1016/s0168-3659(01)00343-1. [PMID: 11489514] - D Bom, D P Curran, S Kruszewski, S G Zimmer, J Thompson Strode, G Kohlhagen, W Du, A J Chavan, K A Fraley, A L Bingcang, L J Latus, Y Pommier, T G Burke. The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity.
Journal of medicinal chemistry.
2000 Oct; 43(21):3970-80. doi:
10.1021/jm000144o. [PMID: 11052802]