N-Acetylcysteine amide (BioDeep_00000838159)
代谢物信息卡片
N-Acetylcysteine amide
化学式: C5H10N2O2S (162.046296)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC(CS)C(=O)N
InChI: InChI=1S/C5H10N2O2S/c1-3(8)7-4(2-10)5(6)9/h4,10H,2H2,1H3,(H2,6,9)(H,7,8)/t4-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mateja Manček-Keber, Iva Hafner-Bratkovič, Duško Lainšček, Mojca Benčina, Tea Govednik, Sara Orehek, Tjaša Plaper, Vid Jazbec, Valter Bergant, Vincent Grass, Andreas Pichlmair, Roman Jerala. Disruption of disulfides within RBD of SARS-CoV-2 spike protein prevents fusion and represents a target for viral entry inhibition by registered drugs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 06; 35(6):e21651. doi:
10.1096/fj.202100560r. [PMID: 34004056] - Rui He, Wenyi Zheng, Tobias Ginman, Håkan Ottosson, Svante Norgren, Ying Zhao, Moustapha Hassan. Pharmacokinetic profile of N-acetylcysteine amide and its main metabolite in mice using new analytical method.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Feb; 143(?):105158. doi:
10.1016/j.ejps.2019.105158. [PMID: 31740394] - Kevin Lüthy, Davide Mei, Baptiste Fischer, Maurizio De Fusco, Jef Swerts, Jone Paesmans, Elena Parrini, Naomi Lubarr, Inge A Meijer, Katherine M Mackenzie, Wang-Tso Lee, Davide Cittaro, Paolo Aridon, Nils Schoovaerts, Wim Versées, Patrik Verstreken, Giorgio Casari, Renzo Guerrini. TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model.
Brain : a journal of neurology.
2019 08; 142(8):2319-2335. doi:
10.1093/brain/awz175. [PMID: 31257402] - Brad King, Jennifer Vance, G Michael Wall, Ronald Shoup. Quantitation of free and total N-acetylcysteine amide and its metabolite N-acetylcysteine in human plasma using derivatization and electrospray LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Mar; 1109(?):25-36. doi:
10.1016/j.jchromb.2019.01.013. [PMID: 30708342] - Yasaswi Maddirala, Shakila Tobwala, Humeyra Karacal, Nuran Ercal. Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats.
BMC ophthalmology.
2017 Apr; 17(1):54. doi:
10.1186/s12886-017-0443-1. [PMID: 28446133] - Torkil Benterud, Martin B Ystgaard, Sophia Manueldas, Leonid Pankratov, Clara Alfaro-Cervello, Geir Florholmen, Muhammad Shakil Ahmed, Leiv Sandvik, Svante Norgren, Magnar Bjørås, Lars O Baumbusch, Ronnaug Solberg, Ola Didrik Saugstad. N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia.
Neonatology.
2017; 111(1):12-21. doi:
10.1159/000447255. [PMID: 27497671] - Serdar Turkyilmaz, Arif Usta, Arif Burak Cekic, Etem Alhan, Birgül Vanizor Kural, Cengiz Ercin. N-acetylcysteine amid reduces pancreatic damage in a rat model of acute necrotizing pancreatitis.
The Journal of surgical research.
2016 06; 203(2):383-9. doi:
10.1016/j.jss.2016.03.004. [PMID: 27363647] - Kyle A Carver, Dongli Yang. N-Acetylcysteine Amide Protects Against Oxidative Stress-Induced Microparticle Release From Human Retinal Pigment Epithelial Cells.
Investigative ophthalmology & visual science.
2016 Feb; 57(2):360-71. doi:
10.1167/iovs.15-17117. [PMID: 26842754] - Ahdab Khayyat, Shakila Tobwala, Marcia Hart, Nuran Ercal. N-acetylcysteine amide, a promising antidote for acetaminophen toxicity.
Toxicology letters.
2016 Jan; 241(?):133-42. doi:
10.1016/j.toxlet.2015.11.008. [PMID: 26602168] - Xuezhong Gong, Yiru Duan, Junli Zheng, Yiquan Wang, Guohua Wang, Svante Norgren, Tom K Hei. Nephroprotective Effects of N-Acetylcysteine Amide against Contrast-Induced Nephropathy through Upregulating Thioredoxin-1, Inhibiting ASK1/p38MAPK Pathway, and Suppressing Oxidative Stress and Apoptosis in Rats.
Oxidative medicine and cellular longevity.
2016; 2016(?):8715185. doi:
10.1155/2016/8715185. [PMID: 28105252] - Muriel Arimon, Shuko Takeda, Kathryn L Post, Sarah Svirsky, Bradley T Hyman, Oksana Berezovska. Oxidative stress and lipid peroxidation are upstream of amyloid pathology.
Neurobiology of disease.
2015 Dec; 84(?):109-19. doi:
10.1016/j.nbd.2015.06.013. [PMID: 26102023] - Shakila Tobwala, Ahdab Khayyat, Weili Fan, Nuran Ercal. Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells.
Experimental biology and medicine (Maywood, N.J.).
2015 Feb; 240(2):261-72. doi:
10.1177/1535370214549520. [PMID: 25245075] - S Tobwala, W Fan, T Stoeger, N Ercal. N-acetylcysteine amide, a thiol antioxidant, prevents bleomycin-induced toxicity in human alveolar basal epithelial cells (A549).
Free radical research.
2013 Sep; 47(9):740-9. doi:
10.3109/10715762.2013.819974. [PMID: 23805793] - X Zhang, S Tobwala, N Ercal. N-acetylcysteine amide protects against methamphetamine-induced tissue damage in CD-1 mice.
Human & experimental toxicology.
2012 Sep; 31(9):931-44. doi:
10.1177/0960327112438287. [PMID: 22354084] - Xuezhong Gong, Gianni Celsi, Katarina Carlsson, Svante Norgren. Protective effects of N-acetylcysteine amide (NACA) on gentamicin-induced apoptosis in LLC-PK1 cells.
Renal failure.
2012; 34(4):487-94. doi:
10.3109/0886022x.2012.655684. [PMID: 22486232] - Jean-Pierre Louboutin, David S Strayer. Blood-brain barrier abnormalities caused by HIV-1 gp120: mechanistic and therapeutic implications.
TheScientificWorldJournal.
2012; 2012(?):482575. doi:
10.1100/2012/482575. [PMID: 22448134] - Andrew M Schimel, Linu Abraham, Douglas Cox, Abdoulaye Sene, Courtney Kraus, Dru S Dace, Nuran Ercal, Rajendra S Apte. N-acetylcysteine amide (NACA) prevents retinal degeneration by up-regulating reduced glutathione production and reversing lipid peroxidation.
The American journal of pathology.
2011 May; 178(5):2032-43. doi:
10.1016/j.ajpath.2011.01.036. [PMID: 21457933] - Joshua W Carey, Eylem Y Pinarci, Suman Penugonda, Humeyra Karacal, Nuran Ercal. In vivo inhibition of l-buthionine-(S,R)-sulfoximine-induced cataracts by a novel antioxidant, N-acetylcysteine amide.
Free radical biology & medicine.
2011 Mar; 50(6):722-9. doi:
10.1016/j.freeradbiomed.2010.12.017. [PMID: 21172425] - Xuezhong Gong, Gianni Celsi, Katarina Carlsson, Svante Norgren, Ming Chen. N-acetylcysteine amide protects renal proximal tubular epithelial cells against iohexol-induced apoptosis by blocking p38 MAPK and iNOS signaling.
American journal of nephrology.
2010; 31(2):178-88. doi:
10.1159/000268161. [PMID: 20016144] - Rong Shi, Chuan-Chin Huang, Robert S Aronstam, Nuran Ercal, Adam Martin, Yue-Wern Huang. N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes.
BMC pharmacology.
2009 Apr; 9(?):7. doi:
10.1186/1471-2210-9-7. [PMID: 19368719] - Jung Ok Ban, Ju Hoon Oh, Tae Myoung Kim, Dae Joong Kim, Heon-Sang Jeong, Sang Bae Han, Jin Tae Hong. Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfur compound isolated from garlic via inhibition of NF-kappaB.
Arthritis research & therapy.
2009; 11(5):R145. doi:
10.1186/ar2819. [PMID: 19788760] - F Schütt, H E Völcker, S Dithmar. [N-acetylcysteine improves lysosomal function and enhances the degradation of photoreceptor outer segments in cultured RPE cells].
Klinische Monatsblatter fur Augenheilkunde.
2007 Jul; 224(7):580-4. doi:
10.1055/s-2007-963339. [PMID: 17657692] - Suman Penugonda, Suneetha Mare, P Lutz, William A Banks, Nuran Ercal. Potentiation of lead-induced cell death in PC12 cells by glutamate: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant.
Toxicology and applied pharmacology.
2006 Oct; 216(2):197-205. doi:
10.1016/j.taap.2006.05.002. [PMID: 16781745] - Orit Bartov, Rukhsana Sultana, D Allan Butterfield, Daphne Atlas. Low molecular weight thiol amides attenuate MAPK activity and protect primary neurons from Abeta(1-42) toxicity.
Brain research.
2006 Jan; 1069(1):198-206. doi:
10.1016/j.brainres.2005.10.079. [PMID: 16386719] - Ofer Sadan, Merav Bahat-Stromza, Yossi Gilgun-Sherki, Daphne Atlas, Eldad Melamed, Daniel Offen. A novel brain-targeted antioxidant (AD4) attenuates haloperidol-induced abnormal movement in rats: implications for tardive dyskinesia.
Clinical neuropharmacology.
2005 Nov; 28(6):285-8. doi:
10.1097/01.wnf.0000191331.54649.e3. [PMID: 16340385] - Suman Penugonda, Suneetha Mare, Glenn Goldstein, William A Banks, Nuran Ercal. Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12.
Brain research.
2005 Sep; 1056(2):132-8. doi:
10.1016/j.brainres.2005.07.032. [PMID: 16120436]