Pradefovir (BioDeep_00000838158)

   


代谢物信息卡片


9-[2-[[4-(3-Chlorophenyl)-2-oxo-1,3,2lambda5-dioxaphosphinan-2-yl]methoxy]ethyl]purin-6-amine

化学式: C17H19ClN5O4P (423.08631340000005)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1COP(=O)(OC1C2=CC(=CC=C2)Cl)COCCN3C=NC4=C(N=CN=C43)N
InChI: InChI=1S/C17H19ClN5O4P/c18-13-3-1-2-12(8-13)14-4-6-26-28(24,27-14)11-25-7-5-23-10-22-15-16(19)20-9-21-17(15)23/h1-3,8-10,14H,4-7,11H2,(H2,19,20,21)

描述信息

D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent

同义名列表

2 个代谢物同义名

9-[2-[[4-(3-Chlorophenyl)-2-oxo-1,3,2lambda5-dioxaphosphinan-2-yl]methoxy]ethyl]purin-6-amine; Pradefovir



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yanhang Gao, Fei Kong, Xinwen Song, Jia Shang, Lvfeng Yao, Jinyu Xia, Yanzhong Peng, Weidong Liu, Huanyu Gong, Mao Mu, Hesong Cui, Tao Han, Wen Chen, Xiaolu Wu, Yongfeng Yang, Xuebing Yan, Zhenjing Jin, Peng Wang, Qingjing Zhu, Liang Chen, Caiyan Zhao, Dengke Zhang, Weili Jin, Daidi Wang, Xiuhong Wen, Chunmei Liu, Jidong Jia, Qing Mao, Yanhua Ding, Xueyuan Jin, Zong Zhang, Qianguo Mao, Guangming Li, Junqi Niu. Pradefovir Treatment in Patients With Chronic Hepatitis B: Week 24 Results From a Multicenter, Double-Blind, Randomized, Noninferiority, Phase 2 Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 06; 74(11):1925-1932. doi: 10.1093/cid/ciab763. [PMID: 34487151]
  • Yanhua Ding, Hong Zhang, Xiaojiao Li, Cuiyun Li, Guiling Chen, Hong Chen, Min Wu, Junqi Niu. Safety, pharmacokinetics and pharmacogenetics of a single ascending dose of pradefovir, a novel liver-targeting, anti-hepatitis B virus drug, in healthy Chinese subjects. Hepatology international. 2017 Jul; 11(4):390-400. doi: 10.1007/s12072-017-9797-y. [PMID: 28560658]
  • Qingqing Xiao, Dan Wang, Wanqiu Yang, Lin Chen, Yitao Ding, Jin Yang. Simultaneous determination of pradefovir, PMEA and tenofovir in HBV patient serum using liquid chromatography-tandem mass spectrometry and application to phase 2 clinical trial. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jun; 1022(?):133-140. doi: 10.1016/j.jchromb.2016.04.019. [PMID: 27089519]
  • K Raja Reddy, Michael C Matelich, Bheemarao G Ugarkar, Jorge E Gómez-Galeno, Jay DaRe, Kristin Ollis, Zhili Sun, William Craigo, Timothy J Colby, James M Fujitaki, Serge H Boyer, Paul D van Poelje, Mark D Erion. Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B. Journal of medicinal chemistry. 2008 Feb; 51(3):666-76. doi: 10.1021/jm7012216. [PMID: 18173234]
  • Chin-chung Lin, Christine Xu, Alice Teng, Li-Tain Yeh, Janet Peterson. Pharmacokinetics of pradefovir and PMEA in healthy volunteers after oral dosing of pradefovir. Journal of clinical pharmacology. 2005 Nov; 45(11):1250-8. doi: 10.1177/0091270005280644. [PMID: 16239358]
  • Chin-Chung Lin, Christine Xu, Nanqun Zhu, David Lourenco, Li-Tain Yeh. Single-dose pharmacokinetics and metabolism of [14C]remofovir in rats and cynomolgus monkeys. Antimicrobial agents and chemotherapy. 2005 Mar; 49(3):925-30. doi: 10.1128/aac.49.3.925-930.2005. [PMID: 15728885]
  • Chin-Chung Lin, Li-Tain Yeh, Domenico Vitarella, Zhi Hong, Mark D Erion. Remofovir mesylate: a prodrug of PMEA with improved liver-targeting and safety in rats and monkeys. Antiviral chemistry & chemotherapy. 2004 Nov; 15(6):307-17. doi: 10.1177/095632020401500603. [PMID: 15646644]