(S,S)-2-{1-Carboxy-2-[3-(3,5-dichloro-benzyl)-3H-imidazol-4-YL]-ethylamino}-4-methyl-pentanoic acid (BioDeep_00000838142)

   


代谢物信息卡片


(S,S)-2-{1-Carboxy-2-[3-(3,5-dichloro-benzyl)-3H-imidazol-4-YL]-ethylamino}-4-methyl-pentanoic acid

化学式: C19H23Cl2N3O4 (427.10655380000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)O)NC(CC1=CN=CN1CC2=CC(=CC(=C2)Cl)Cl)C(=O)O
InChI: InChI=1S/C19H23Cl2N3O4/c1-11(2)3-16(18(25)26)23-17(19(27)28)7-15-8-22-10-24(15)9-12-4-13(20)6-14(21)5-12/h4-6,8,10-11,16-17,23H,3,7,9H2,1-2H3,(H,25,26)(H,27,28)/t16-,17-/m0/s1

描述信息

同义名列表

1 个代谢物同义名

(S,S)-2-{1-Carboxy-2-[3-(3,5-dichloro-benzyl)-3H-imidazol-4-YL]-ethylamino}-4-methyl-pentanoic acid



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

PlantCyc(0)

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Babak Nami, Avrin Ghanaeian, Kasra Ghanaeian, Rozhin Houri, Negin Nami, Armin Ghasemi-Dizgah, Oana Caluseriu. The interaction of the severe acute respiratory syndrome coronavirus 2 spike protein with drug-inhibited angiotensin converting enzyme 2 studied by molecular dynamics simulation. Journal of hypertension. 2021 08; 39(8):1705-1716. doi: 10.1097/hjh.0000000000002829. [PMID: 34188005]
  • Apurba Bhattarai, Shristi Pawnikar, Yinglong Miao. Mechanism of Ligand Recognition by Human ACE2 Receptor. The journal of physical chemistry letters. 2021 May; 12(20):4814-4822. doi: 10.1021/acs.jpclett.1c01064. [PMID: 33999630]
  • Juan E Tichauer, Dagoberto Soto, Max Andresen. Characterization of the Modulatory Effect of Hydroxychloroquine on ACE2 Activity: New Insights in relation to COVID-19. BioMed research international. 2021; 2021(?):6614000. doi: 10.1155/2021/6614000. [PMID: 34337036]
  • Peter Serfozo, Jan Wysocki, Gvantca Gulua, Arndt Schulze, Minghao Ye, Pan Liu, Jing Jin, Michael Bader, Timo Myöhänen, J Arturo García-Horsman, Daniel Batlle. Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent. Hypertension (Dallas, Tex. : 1979). 2020 01; 75(1):173-182. doi: 10.1161/hypertensionaha.119.14071. [PMID: 31786979]
  • Fengxia Xiao, Kevin D Burns. Measurement of Angiotensin Converting Enzyme 2 Activity in Biological Fluid (ACE2). Methods in molecular biology (Clifton, N.J.). 2017; 1527(?):101-115. doi: 10.1007/978-1-4939-6625-7_8. [PMID: 28116710]
  • Oliver Domenig, Arndt Manzel, Nadja Grobe, Eva Königshausen, Christopher C Kaltenecker, Johannes J Kovarik, Johannes Stegbauer, Susan B Gurley, Dunja van Oyen, Marlies Antlanger, Michael Bader, Daisy Motta-Santos, Robson A Santos, Khalid M Elased, Marcus D Säemann, Ralf A Linker, Marko Poglitsch. Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney. Scientific reports. 2016 09; 6(?):33678. doi: 10.1038/srep33678. [PMID: 27649628]
  • Philipp K Haber, Minghao Ye, Jan Wysocki, Christoph Maier, Syed K Haque, Daniel Batlle. Angiotensin-converting enzyme 2-independent action of presumed angiotensin-converting enzyme 2 activators: studies in vivo, ex vivo, and in vitro. Hypertension (Dallas, Tex. : 1979). 2014 Apr; 63(4):774-82. doi: 10.1161/hypertensionaha.113.02856. [PMID: 24446061]
  • Sarfaraz Ahmad, Chih-Chang Wei, Jose Tallaj, Louis J Dell'Italia, Norihito Moniwa, Jasmina Varagic, Carlos M Ferrario. Chymase mediates angiotensin-(1-12) metabolism in normal human hearts. Journal of the American Society of Hypertension : JASH. 2013 Mar; 7(2):128-36. doi: 10.1016/j.jash.2012.12.003. [PMID: 23312967]
  • Minghao Ye, Jan Wysocki, Francisco R Gonzalez-Pacheco, Mahmoud Salem, Karla Evora, Laura Garcia-Halpin, Marko Poglitsch, Manfred Schuster, Daniel Batlle. Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2. Hypertension (Dallas, Tex. : 1979). 2012 Sep; 60(3):730-40. doi: 10.1161/hypertensionaha.112.198622. [PMID: 22777933]
  • Aaron J Trask, Leanne Groban, Brian M Westwood, Jasmina Varagic, Detlev Ganten, Patricia E Gallagher, Mark C Chappell, Carlos M Ferrario. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. American journal of hypertension. 2010 Jun; 23(6):687-93. doi: 10.1038/ajh.2010.51. [PMID: 20300067]
  • Marc Dilauro, Joseph Zimpelmann, Susan J Robertson, Dominique Genest, Kevin D Burns. Effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease. American journal of physiology. Renal physiology. 2010 Jun; 298(6):F1523-32. doi: 10.1152/ajprenal.00426.2009. [PMID: 20357030]
  • TanYa M Gwathmey, Karl D Pendergrass, Sean D Reid, James C Rose, Debra I Diz, Mark C Chappell. Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension (Dallas, Tex. : 1979). 2010 Jan; 55(1):166-71. doi: 10.1161/hypertensionaha.109.141622. [PMID: 19948986]
  • Debra I Diz, Maria A Garcia-Espinosa, Stephen Gegick, Ellen N Tommasi, Carlos M Ferrario, E Ann Tallant, Mark C Chappell, Patricia E Gallagher. Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Experimental physiology. 2008 May; 93(5):694-700. doi: 10.1113/expphysiol.2007.040261. [PMID: 18356558]
  • M J Soler, J Wysocki, M Ye, J Lloveras, Y Kanwar, D Batlle. ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice. Kidney international. 2007 Sep; 72(5):614-23. doi: 10.1038/sj.ki.5002373. [PMID: 17579661]
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