Contezolid (BioDeep_00000838089)
代谢物信息卡片
化学式: C18H15F3N4O4 (408.1045346)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(C=CC1=O)C2=C(C=C(C(=C2F)F)N3CC(OC3=O)CNC4=NOC=C4)F
InChI: InChI=1S/C18H15F3N4O4/c19-12-7-13(15(20)16(21)17(12)24-4-1-10(26)2-5-24)25-9-11(29-18(25)27)8-22-14-3-6-28-23-14/h1,3-4,6-7,11H,2,5,8-9H2,(H,22,23)/t11-/m0/s1
描述信息
D000890 - Anti-Infective Agents > D023303 - Oxazolidinones
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D11297
- PubChem: 25184541
- DrugBank: DB12796
- ChEMBL: CHEMBL3287379
- CAS: 1112968-42-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yu Wang, Hailan Wu, Junzhen Wu, Yaxin Fan, Xiaofen Liu, Yi Li, Jiali Hu, Jing Zhang, Beining Guo. Development and validation of ultra-performance liquid chromatography-tandem mass spectrometric methods for simultaneous and rapid determination of contezolid and its major metabolite M2 in plasma and urine samples and its application to a study in subjects with moderate liver impairment.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Feb; 1191(?):123129. doi:
10.1016/j.jchromb.2022.123129. [PMID: 35066246] - Xiaojie Wu, Jian Meng, Hong Yuan, Dafang Zhong, Jicheng Yu, Guoying Cao, Xingdang Liu, Beining Guo, Yuancheng Chen, Yi Li, Yaoguo Shi, Mikhail F Gordeev, Jufang Wu, Jing Zhang. Pharmacokinetics and Disposition of Contezolid in Humans: Resolution of a Disproportionate Human Metabolite for Clinical Development.
Antimicrobial agents and chemotherapy.
2021 10; 65(11):e0040921. doi:
10.1128/aac.00409-21. [PMID: 34398672] - Junzhen Wu, Guoying Cao, Hailan Wu, Yuancheng Chen, Beining Guo, Xiaojie Wu, Jicheng Yu, Kanhong Ni, Jin Qian, Li Wang, Jufang Wu, Yu Wang, Hong Yuan, Jing Zhang, Yuewen Xi. Evaluation of the Effect of Contezolid (MRX-I) on the Corrected QT Interval in a Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study in Healthy Chinese Volunteers.
Antimicrobial agents and chemotherapy.
2020 05; 64(6):. doi:
10.1128/aac.02158-19. [PMID: 32229495] - Junzhen Wu, Kun Wang, Yuancheng Chen, Hong Yuan, Li Li, Jing Zhang. Concentration-response modeling of ECG data from early-phase clinical studies to assess QT prolongation risk of contezolid (MRX-I), an oxazolidinone antibacterial agent.
Journal of pharmacokinetics and pharmacodynamics.
2019 12; 46(6):531-541. doi:
10.1007/s10928-019-09650-7. [PMID: 31410633] - Junzhen Wu, Hailan Wu, Yu Wang, Yuancheng Chen, Beining Guo, Guoying Cao, Xiaojie Wu, Jicheng Yu, Jufang Wu, Demei Zhu, Yan Guo, Hong Yuan, Fupin Hu, Jing Zhang. Tolerability and Pharmacokinetics of Contezolid at Therapeutic and Supratherapeutic Doses in Healthy Chinese Subjects, and Assessment of Contezolid Dosing Regimens Based on Pharmacokinetic/Pharmacodynamic Analysis.
Clinical therapeutics.
2019 06; 41(6):1164-1174.e4. doi:
10.1016/j.clinthera.2019.04.025. [PMID: 31126694] - Xiaojie Wu, Yunfei Li, Jing Zhang, Yingyuan Zhang, Jicheng Yu, Guoying Cao, Yuancheng Chen, Beining Guo, Yaoguo Shi, Jun Huang, Yuran Cao, Xiaofang Liu, Jufang Wu, Mikhail Fedorovich Gordeev, Hong Yuan, Wen Wang. Short-term Safety, Tolerability, and Pharmacokinetics of MRX-I, an Oxazolidinone Antibacterial Agent, in Healthy Chinese Subjects.
Clinical therapeutics.
2018 02; 40(2):322-332.e5. doi:
10.1016/j.clinthera.2017.12.017. [PMID: 29398160] - Thomas A Baillie, Deepak Dalvie, Ivonne M C M Rietjens, S Cyrus Khojasteh. Biotransformation and bioactivation reactions - 2015 literature highlights.
Drug metabolism reviews.
2016 05; 48(2):113-38. doi:
10.1080/03602532.2016.1195404. [PMID: 27362326] - Jian Meng, Dafang Zhong, Liang Li, Zhengyu Yuan, Hong Yuan, Cen Xie, Jialan Zhou, Chen Li, Mikhail Fedorovich Gordeev, Jinqian Liu, Xiaoyan Chen. Metabolism of MRX-I, a novel antibacterial oxazolidinone, in humans: the oxidative ring opening of 2,3-Dihydropyridin-4-one catalyzed by non-P450 enzymes.
Drug metabolism and disposition: the biological fate of chemicals.
2015 May; 43(5):646-59. doi:
10.1124/dmd.114.061747. [PMID: 25710940]