(R)-Fluoxetine (BioDeep_00000838084)

   


代谢物信息卡片


(R)-Fluoxetine

化学式: C17H18F3NO (309.1340414)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F
InChI: InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3/t16-/m1/s1

描述信息

同义名列表

1 个代谢物同义名

(R)-Fluoxetine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Marielle Hess, Georg Höfner, Klaus T Wanner. (S)- and (R)-fluoxetine as native markers in mass spectrometry (MS) binding assays addressing the serotonin transporter. ChemMedChem. 2011 Oct; 6(10):1900-8. doi: 10.1002/cmdc.201100251. [PMID: 21793219]
  • Susanna Nencetti, Maria R Mazzoni, Gabriella Ortore, Annalina Lapucci, Janette Giuntini, Elisabetta Orlandini, Irene Banti, Elisa Nuti, Antonio Lucacchini, Gino Giannaccini, Armando Rossello. Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors. European journal of medicinal chemistry. 2011 Mar; 46(3):825-34. doi: 10.1016/j.ejmech.2010.12.018. [PMID: 21272963]
  • Timothy W Chow, András Szeitz, Dan W Rurak, K Wayne Riggs. A validated enantioselective assay for the simultaneous quantitation of (R)-, (S)-fluoxetine and (R)-, (S)-norfluoxetine in ovine plasma using liquid chromatography with tandem mass spectrometry (LC/MS/MS). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Feb; 879(5-6):349-58. doi: 10.1016/j.jchromb.2010.12.020. [PMID: 21242112]
  • Peng Zhang, George Cyriac, Theresa Kopajtic, Yongfang Zhao, Jonathan A Javitch, Jonathan L Katz, Amy Hauck Newman. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. Journal of medicinal chemistry. 2010 Aug; 53(16):6112-21. doi: 10.1021/jm1005034. [PMID: 20672825]
  • Zheng Zhou, Juan Zhen, Nathan K Karpowich, Christopher J Law, Maarten E A Reith, Da-Neng Wang. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nature structural & molecular biology. 2009 Jun; 16(6):652-7. doi: 10.1038/nsmb.1602. [PMID: 19430461]
  • Maria G Scordo, Edoardo Spina, Marja-Liisa Dahl, Giuliana Gatti, Emilio Perucca. Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine. Basic & clinical pharmacology & toxicology. 2005 Nov; 97(5):296-301. doi: 10.1111/j.1742-7843.2005.pto_194.x. [PMID: 16236141]
  • Michael E Henry, Mark E Schmidt, John Hennen, Rosemond A Villafuerte, Michelle L Butman, Pierre Tran, Lynn T Kerner, Bruce Cohen, Perry F Renshaw. A comparison of brain and serum pharmacokinetics of R-fluoxetine and racemic fluoxetine: A 19-F MRS study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2005 Aug; 30(8):1576-83. doi: 10.1038/sj.npp.1300749. [PMID: 15886723]
  • John Kim, K Wayne Riggs, Dan W Rurak. Stereoselective pharmacokinetics of fluoxetine and norfluoxetine enantiomers in pregnant sheep. Drug metabolism and disposition: the biological fate of chemicals. 2004 Feb; 32(2):212-21. doi: 10.1124/dmd.32.2.212. [PMID: 14744943]
  • Aurelio Orjales, Ramón Mosquera, Antonio Toledo, M Carmen Pumar, Neftalí García, Lourdes Cortizo, Luis Labeaga, Ana Innerárity. Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters. Journal of medicinal chemistry. 2003 Dec; 46(25):5512-32. doi: 10.1021/jm0309349. [PMID: 14640559]
  • Giovanna Jannuzzi, Giuliana Gatti, Paolo Magni, Edoardo Spina, Roberta Pacifici, Piergiorgio Zuccaro, Riccardo Torta, Laura Guarneri, Emilio Perucca. Plasma concentrations of the enantiomers of fluoxetine and norfluoxetine: sources of variability and preliminary observations on relations with clinical response. Therapeutic drug monitoring. 2002 Oct; 24(5):616-27. doi: 10.1097/00007691-200210000-00006. [PMID: 12352933]
  • J M Owens, D L Knight, C B Nemeroff. [Second generation SSRIS: human monoamine transporter binding profile of escitalopram and R-fluoxetine]. L'Encephale. 2002 Jul; 28(4):350-5. doi: NULL. [PMID: 12232544]
  • M J Owens, D L Knight, C B Nemeroff. Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biological psychiatry. 2001 Sep; 50(5):345-50. doi: 10.1016/s0006-3223(01)01145-3. [PMID: 11543737]