Altropane (BioDeep_00000838079)
代谢物信息卡片
Altropane
化学式: C18H21FINO2 (429.0601008)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC(=O)C1C2CCC(N2CC=CI)CC1C3=CC=C(C=C3)F
InChI: InChI=1S/C18H21FINO2/c1-23-18(22)17-15(12-3-5-13(19)6-4-12)11-14-7-8-16(17)21(14)10-2-9-20/h2-6,9,14-17H,7-8,10-11H2,1H3/b9-2+/t14-,15+,16+,17-/m0/s1
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:135696
- PubChem: 6440180
- DrugBank: DB04947
- ChEMBL: CHEMBL4301492
- CAS: 180468-34-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Diego A Pizzagalli, Sabina Berretta, Dustin Wooten, Franziska Goer, Kanoelani T Pilobello, Poornima Kumar, Laura Murray, Miranda Beltzer, Anne Boyer-Boiteau, Nathanial Alpert, Georges El Fakhri, Naguib Mechawar, Gordana Vitaliano, Gustavo Turecki, Marc Normandin. Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder: In Vivo Positron Emission Tomography and Postmortem Evidence.
JAMA psychiatry.
2019 08; 76(8):854-861. doi:
10.1001/jamapsychiatry.2019.0801. [PMID: 31042280] - Julia Shirvan, Nathan Clement, Rong Ye, Samantha Katz, Aaron Schultz, Keith A Johnson, Teresa Gomez-Isla, Matthew Frosch, John H Growdon, Stephen N Gomperts. Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease.
Neurology.
2019 07; 93(5):e476-e484. doi:
10.1212/wnl.0000000000007855. [PMID: 31243072] - Anna Rieckmann, Trey Hedden, Alayna P Younger, Reisa A Sperling, Keith A Johnson, Randy L Buckner. Dopamine transporter availability in clinically normal aging is associated with individual differences in white matter integrity.
Human brain mapping.
2016 Feb; 37(2):621-31. doi:
10.1002/hbm.23054. [PMID: 26542307] - Thomas J Spencer, Joseph Biederman, Stephen V Faraone, Bertha K Madras, Ali A Bonab, Darin D Dougherty, Holly Batchelder, Allison Clarke, Alan J Fischman. Functional genomics of attention-deficit/hyperactivity disorder (ADHD) risk alleles on dopamine transporter binding in ADHD and healthy control subjects.
Biological psychiatry.
2013 Jul; 74(2):84-9. doi:
10.1016/j.biopsych.2012.11.010. [PMID: 23273726] - Thomas J Spencer, Ali A Bonab, Darin D Dougherty, Tara Mirto, Jessica Martin, Allison Clarke, Alan J Fischman. Understanding the central pharmacokinetics of spheroidal oral drug absorption system (SODAS) dexmethylphenidate: a positron emission tomography study of dopamine transporter receptor occupancy measured with C-11 altropane.
The Journal of clinical psychiatry.
2012 Mar; 73(3):346-52. doi:
10.4088/jcp.10m06393. [PMID: 22154896] - Jacqueline A Gleave, Troy H Farncombe, Chantal Saab, Laurie C Doering. Correlative single photon emission computed tomography imaging of [123I]altropane binding in the rat model of Parkinson's.
Nuclear medicine and biology.
2011 Jul; 38(5):741-9. doi:
10.1016/j.nucmedbio.2010.12.006. [PMID: 21718949] - Thomas J Spencer, Bertha K Madras, Ali A Bonab, Darin D Dougherty, Allison Clarke, Tara Mirto, Jessica Martin, Alan J Fischman. A positron emission tomography study examining the dopaminergic activity of armodafinil in adults using [¹¹C]altropane and [¹¹C]raclopride.
Biological psychiatry.
2010 Nov; 68(10):964-70. doi:
10.1016/j.biopsych.2010.08.026. [PMID: 21035624] - Thomas J Spencer, Joseph Biederman, Bertha K Madras, Darin D Dougherty, Ali A Bonab, Elijahu Livni, Peter C Meltzer, Jessica Martin, Scott Rauch, Alan J Fischman. Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane.
Biological psychiatry.
2007 Nov; 62(9):1059-61. doi:
10.1016/j.biopsych.2006.12.008. [PMID: 17511972] - Thomas J Spencer, Joseph Biederman, Patrick E Ciccone, Bertha K Madras, Darin D Dougherty, Ali A Bonab, Elijahu Livni, Dolly A Parasrampuria, Alan J Fischman. PET study examining pharmacokinetics, detection and likeability, and dopamine transporter receptor occupancy of short- and long-acting oral methylphenidate.
The American journal of psychiatry.
2006 Mar; 163(3):387-95. doi:
10.1176/appi.ajp.163.3.387. [PMID: 16513858] - Thomas J Spencer, Joseph Biederman, Bertha K Madras, Stephen V Faraone, Darin D Dougherty, Ali A Bonab, Alan J Fischman. In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporter.
Biological psychiatry.
2005 Jun; 57(11):1293-300. doi:
10.1016/j.biopsych.2005.03.036. [PMID: 15950001] - A J Fischman, A A Bonab, J W Babich, E Livni, N M Alpert, P C Meltzer, B K Madras. [(11)C, (127)I] Altropane: a highly selective ligand for PET imaging of dopamine transporter sites.
Synapse (New York, N.Y.).
2001 Mar; 39(4):332-42. doi:
10.1002/1098-2396(20010315)39:4<332::aid-syn1017>3.0.co;2-x. [PMID: 11169784] - K Hettiarachchi, C E Green, S Ridge, B Wu, P Catz, M A Salem. Analysis of 2beta-carbomethoxy-3beta-(4-fluorophenyl)-N-(3-iodo-E-allyl)nortropane in rat plasma. I. Method development and validation by capillary electrophoresis.
Journal of chromatography. A.
2000 Oct; 895(1-2):87-100. doi:
10.1016/s0021-9673(00)00668-3. [PMID: 11105851] - A J Fischman, A A Bonab, J W Babich, E P Palmer, N M Alpert, D R Elmaleh, R J Callahan, S A Barrow, W Graham, P C Meltzer, R N Hanson, B K Madras. Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters.
Synapse (New York, N.Y.).
1998 Jun; 29(2):128-41. doi:
10.1002/(sici)1098-2396(199806)29:2<128::aid-syn4>3.0.co;2-9. [PMID: 9593103] - B K Madras, P C Meltzer, A Y Liang, D R Elmaleh, J Babich, A J Fischman. Altropane, a SPECT or PET imaging probe for dopamine neurons: I. Dopamine transporter binding in primate brain.
Synapse (New York, N.Y.).
1998 Jun; 29(2):93-104. doi:
10.1002/(sici)1098-2396(199806)29:2<93::aid-syn1>3.0.co;2-5. [PMID: 9593100] - B K Madras, L M Gracz, P C Meltzer, A Y Liang, D R Elmaleh, M J Kaufman, A J Fischman. Altropane, a SPECT or PET imaging probe for dopamine neurons: II. Distribution to dopamine-rich regions of primate brain.
Synapse (New York, N.Y.).
1998 Jun; 29(2):105-15. doi:
10.1002/(sici)1098-2396(199806)29:2<105::aid-syn2>3.0.co;2-b. [PMID: 9593101] - B K Madras, L M Gracz, M A Fahey, D Elmaleh, P C Meltzer, A Y Liang, E G Stopa, J Babich, A J Fischman. Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brain.
Synapse (New York, N.Y.).
1998 Jun; 29(2):116-27. doi:
10.1002/(sici)1098-2396(199806)29:2<116::aid-syn3>3.0.co;2-a. [PMID: 9593102] - A J Fischman, J W Babich, D R Elmaleh, S A Barrow, P Meltzer, R N Hanson, B K Madras. SPECT imaging of dopamine transporter sites in normal and MPTP-Treated rhesus monkeys.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1997 Jan; 38(1):144-50. doi:
NULL. [PMID: 8998169] - D R Elmaleh, A J Fischman, T M Shoup, C Byon, R N Hanson, A Y Liang, P C Meltzer, B K Madras. Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1996 Jul; 37(7):1197-202. doi:
NULL. [PMID: 8965198]