Gdc-0152 (BioDeep_00000838059)

   


代谢物信息卡片


Gdc-0152

化学式: C25H34N6O3S (498.2412974)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC
InChI: InChI=1S/C25H34N6O3S/c1-16(26-2)22(32)27-21(18-12-7-4-8-13-18)25(34)31-15-9-14-19(31)23(33)28-24-20(29-30-35-24)17-10-5-3-6-11-17/h3,5-6,10-11,16,18-19,21,26H,4,7-9,12-15H2,1-2H3,(H,27,32)(H,28,33)/t16-,19-,21-/m0/s1

描述信息

C274 - Antineoplastic Agent > C129839 - Apoptotic Pathway-targeting Antineoplastic Agent

同义名列表

1 个代谢物同义名

Gdc-0152



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Luca Gambini, Carlo Baggio, Parima Udompholkul, Jennifer Jossart, Ahmed F Salem, J Jefferson P Perry, Maurizio Pellecchia. Covalent Inhibitors of Protein-Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues. Journal of medicinal chemistry. 2019 06; 62(11):5616-5627. doi: 10.1021/acs.jmedchem.9b00561. [PMID: 31095386]
  • Qin Yue, Teresa Mulder, Patrick J Rudewicz, Eric Solon, Nageshwar Budha, Joseph A Ware, Joseph Lyssikatos, Cornelis E C A Hop, Harvey Wong, S Cyrus Khojasteh. Evaluation of metabolism and disposition of GDC-0152 in rats using 14C labeling strategy at two different positions: a novel formation of hippuric acid from 4-phenyl-5-amino-1,2,3-thiadiazole. Drug metabolism and disposition: the biological fate of chemicals. 2013 Feb; 41(2):508-17. doi: 10.1124/dmd.112.047019. [PMID: 23223496]
  • Young G Shin, Steve A Jones, Stan C Murakami, Nageshwar Budha, Joseph Ware, Harvey Wong, Michael H Buonarati, Brian Dean, Cornelis E C A Hop. Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0152 in human plasma using solid-phase extraction. Biomedical chromatography : BMC. 2013 Jan; 27(1):102-10. doi: 10.1002/bmc.2754. [PMID: 22623056]
  • Rebecca I Erickson, Jacqueline Tarrant, Gary Cain, Sock-Cheng Lewin-Koh, Noel Dybdal, Harvey Wong, Elizabeth Blackwood, Kristina West, Ronald Steigerwalt, Michael Mamounas, John A Flygare, Kenjie Amemiya, Donna Dambach, Wayne J Fairbrother, Dolores Diaz. Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Jan; 131(1):247-58. doi: 10.1093/toxsci/kfs265. [PMID: 22956632]
  • Harvey Wong, Nageshwar R Budha, Kristina West, Elizabeth Blackwood, Joseph A Ware, Ron Yu, Walter C Darbonne, Stephen E Gould, Ronald Steigerwalt, Rebecca Erickson, Cornelis E A C Hop, Patricia LoRusso, S Gail Eckhardt, Andrew Wagner, Iris T Chan, Michael Mamounas, John A Flygare, Wayne J Fairbrother. Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: a translational toxicokinetic/toxicodynamic analysis. Toxicological sciences : an official journal of the Society of Toxicology. 2012 Nov; 130(1):205-13. doi: 10.1093/toxsci/kfs235. [PMID: 22843607]
  • John A Flygare, Maureen Beresini, Nageshwar Budha, Helen Chan, Iris T Chan, Sravanthi Cheeti, Frederick Cohen, Kurt Deshayes, Karl Doerner, S Gail Eckhardt, Linda O Elliott, Bainian Feng, Matthew C Franklin, Stacy Frankovitz Reisner, Lewis Gazzard, Jason Halladay, Sarah G Hymowitz, Hank La, Patricia LoRusso, Brigitte Maurer, Lesley Murray, Emile Plise, Clifford Quan, Jean-Philippe Stephan, Shin G Young, Jeffrey Tom, Vickie Tsui, Joanne Um, Eugene Varfolomeev, Domagoj Vucic, Andrew J Wagner, Heidi J A Wallweber, Lan Wang, Joseph Ware, Zhaoyang Wen, Harvey Wong, Jonathan M Wong, Melisa Wong, Susan Wong, Ron Yu, Kerry Zobel, Wayne J Fairbrother. Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). Journal of medicinal chemistry. 2012 May; 55(9):4101-13. doi: 10.1021/jm300060k. [PMID: 22413863]