Sabarubicin (BioDeep_00000838051)
代谢物信息卡片
化学式: C32H37NO13 (643.2264792000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(CC(O1)OC2C(OC(CC2O)OC3CC(CC4=C3C(=C5C(=C4O)C(=O)C6=CC=CC=C6C5=O)O)(C(=O)CO)O)C)N)O
InChI: InChI=1S/C32H37NO13/c1-12-26(37)17(33)7-21(43-12)46-31-13(2)44-22(8-18(31)35)45-19-10-32(42,20(36)11-34)9-16-23(19)30(41)25-24(29(16)40)27(38)14-5-3-4-6-15(14)28(25)39/h3-6,12-13,17-19,21-22,26,31,34-35,37,40-42H,7-11,33H2,1-2H3/t12-,13-,17-,18-,19-,21-,22-,26+,31+,32-/m0/s1
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yan Zhang, Peng Liu, Ning Li, Di Wu, Yun Feng, Yuanyuan Song, Yuankai Shi, Xiaohong Han. Development and validation of a UHPLC-MS/MS method for simultaneous quantitation the plasma concentration of Sabarubicin and its alcohol metabolite M3 in Chinese small cell lung cancer patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jul; 1025(?):119-25. doi:
10.1016/j.jchromb.2016.04.050. [PMID: 27243582] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - A M E Bos, K Boom, A A Vinks, H M Boezen, J Wanders, P Dombernovsky, S Aamdal, E G E de Vries, D R A Uges. Development of an optimal sampling strategy for clinical pharmacokinetic studies of the novel anthracycline disaccharide analogue MEN-10755.
Cancer chemotherapy and pharmacology.
2004 Jul; 54(1):64-70. doi:
10.1007/s00280-004-0772-7. [PMID: 15069581] - Luigi Messori, Francesca Piccioli, Silvia Gabrielli, Pierluigi Orioli, Leonardo Angeloni, Cristina Di Bugno. The disaccharide anthracycline MEN 10755 binds human serum albumin to a non-classical drug binding site.
Bioorganic & medicinal chemistry.
2002 Nov; 10(11):3425-30. doi:
10.1016/s0968-0896(02)00265-1. [PMID: 12213455] - A M Bos, E G de Vries, P Dombernovsky, S Aamdal, D R Uges, D Schrijvers, J Wanders, M W Roelvink, A R Hanauske, S Bortini, A Capriati, A E Crea, J B Vermorken. Pharmacokinetics of MEN-10755, a novel anthracycline disaccharide analogue, in two phase I studies in adults with advanced solid tumours.
Cancer chemotherapy and pharmacology.
2001 Nov; 48(5):361-9. doi:
10.1007/s002800100350. [PMID: 11761453] - O Gonzalez-Paz, D Polizzi, M De Cesare, F Zunino, M Bigioni, C A Maggi, S Manzini, G Pratesi. Tissue distribution, antitumour activity and in vivo apoptosis induction by MEN10755 in nude mice.
European journal of cancer (Oxford, England : 1990).
2001 Feb; 37(3):431-7. doi:
10.1016/s0959-8049(00)00414-7. [PMID: 11239767]