Imiglitazar (BioDeep_00000838050)
代谢物信息卡片
化学式: C28H26N2O5 (470.18416260000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(N=C(O1)C2=CC=CC=C2)COC3=CC=C(C=C3)CON=C(CCC(=O)O)C4=CC=CC=C4
InChI: InChI=1S/C28H26N2O5/c1-20-26(29-28(35-20)23-10-6-3-7-11-23)19-33-24-14-12-21(13-15-24)18-34-30-25(16-17-27(31)32)22-8-4-2-5-9-22/h2-15H,16-19H2,1H3,(H,31,32)/b30-25+
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C154291 - Peroxisome Proliferator-Activated Receptor Agonist
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Harikishore Pingali, Mukul Jain, Shailesh Shah, Pandurang Zaware, Pankaj Makadia, Suresh Pola, Baban Thube, Darshit Patel, Pravin Patil, Priyanka Priyadarshini, Dinesh Suthar, Maanan Shah, Suresh Giri, Pankaj Patel. Design and synthesis of novel bis-oximinoalkanoic acids as potent PPAR alpha agonists.
Bioorganic & medicinal chemistry letters.
2010 Feb; 20(3):1156-61. doi:
10.1016/j.bmcl.2009.12.022. [PMID: 20022492] - Shi-Ying Ding, Xenia T Tigno, Gheorghe T Braileanu, Katsuhiko Ito, Barbara C Hansen. A novel peroxisome proliferator--activated receptor alpha/gamma dual agonist ameliorates dyslipidemia and insulin resistance in prediabetic rhesus monkeys.
Metabolism: clinical and experimental.
2007 Oct; 56(10):1334-9. doi:
10.1016/j.metabol.2007.05.019. [PMID: 17884441] - D Andes, W A Craig. Pharmacodynamics of a new cephalosporin, PPI-0903 (TAK-599), active against methicillin-resistant Staphylococcus aureus in murine thigh and lung infection models: identification of an in vivo pharmacokinetic-pharmacodynamic target.
Antimicrobial agents and chemotherapy.
2006 Apr; 50(4):1376-83. doi:
10.1128/aac.50.4.1376-1383.2006. [PMID: 16569855] - Naoto Seki, Hideaki Bujo, Meizi Jiang, Manabu Shibasaki, Kazuo Takahashi, Naotake Hashimoto, Yasushi Saito. A potent activator of PPARalpha and gamma reduces the vascular cell recruitment and inhibits the intimal thickning in hypercholesterolemic rabbits.
Atherosclerosis.
2005 Jan; 178(1):1-7. doi:
10.1016/j.atherosclerosis.2004.08.015. [PMID: 15585194] - Hiroshi Imoto, Mitsuharu Matsumoto, Hiroyuki Odaka, Junichi Sakamoto, Hiroyuki Kimura, Masami Nonaka, Yutaka Kiyota, Yu Momose. Studies on non-thiazolidinedione antidiabetic agents. 3. Preparation and biological activity of the metabolites of TAK-559.
Chemical & pharmaceutical bulletin.
2004 Jan; 52(1):120-4. doi:
10.1248/cpb.52.120. [PMID: 14709878]