PF-04620110 (BioDeep_00000838049)
代谢物信息卡片
化学式: C21H24N4O4 (396.1797)
中文名称:
谱图信息:
最多检出来源 () %
分子结构信息
SMILES: C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)N3CCOC4=NC=NC(=C4C3=O)N
InChI: InChI=1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)
描述信息
PF-04620110 is a potent, selective and orally bioavailable diglyceride acyltransferase-1 (DGAT-1) inhibitor with an IC50 of 19 nM[1].
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 46926360
- DrugBank: DB14887
- ChEMBL: CHEMBL1835919
- CAS: 1109276-89-2
- medchemexpress: HY-13009
分类词条
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Fan He, Wei Zheng, Yongzhuang Chen, Chengke Mo, Yilu Chen. Development and validation of a simple and sensitive high-resolution LC/MS method for determination of PF-04620110 in dog plasma: Application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2019 Sep; 33(9):e4562. doi:
10.1002/bmc.4562
. [PMID: 31017300] - Mui Cheung, Raghuram S Tangirala, Sridhar R Bethi, Hemant V Joshi, Jennifer L Ariazi, Vijaya G Tirunagaru, Sanjay Kumar. Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1.
ACS medicinal chemistry letters.
2018 Feb; 9(2):103-108. doi:
10.1021/acsmedchemlett.7b00450
. [PMID: 29456796] - Robert L Dow, Melissa P Andrews, Jian-Cheng Li, E Michael Gibbs, Angel Guzman-Perez, Jennifer L Laperle, Qifang Li, Dawn Mather, Michael J Munchhof, Mark Niosi, Leena Patel, Christian Perreault, Susan Tapley, William J Zavadoski. Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.
Bioorganic & medicinal chemistry.
2013 Sep; 21(17):5081-97. doi:
10.1016/j.bmc.2013.06.045
. [PMID: 23871442] - Kyeong-Ryoon Lee, Sung Heum Choi, Jin-Sook Song, Hyewon Seo, Yoon-Jee Chae, Hwang Eui Cho, Jin Hee Ahn, Sung-Hoon Ahn, Myung Ae Bae. Determination of PF-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies.
Biomedical chromatography : BMC.
2013 Jul; 27(7):846-52. doi:
10.1002/bmc.2869
. [PMID: 23420715] - Benjamin S Maciejewski, Jennifer L LaPerle, Danny Chen, Avijit Ghosh, William J Zavadoski, Thomas S McDonald, Tara B Manion, Dawn Mather, Terrell A Patterson, Maya Hanna, Steven Watkins, E Michael Gibbs, Roberto A Calle, Claire M Steppan. Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans.
American journal of physiology. Gastrointestinal and liver physiology.
2013 Jun; 304(11):G958-69. doi:
10.1152/ajpgi.00384.2012
. [PMID: 23558010] - Robert L Dow, Jian-Cheng Li, Michael P Pence, E Michael Gibbs, Jennifer L LaPerle, John Litchfield, David W Piotrowski, Michael J Munchhof, Tara B Manion, William J Zavadoski, Gregory S Walker, R Kirk McPherson, Susan Tapley, Eliot Sugarman, Angel Guzman-Perez, Paul DaSilva-Jardine. Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.
ACS medicinal chemistry letters.
2011 May; 2(5):407-12. doi:
10.1021/ml200051p
. [PMID: 24900321]