Berzosertib (BioDeep_00000838037)
代谢物信息卡片
化学式: C24H25N5O3S (463.16780200000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)S(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C3=CC(=NO3)C4=CC=C(C=C4)CNC)N
InChI: InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:131166
- KEGGdrug: D11148
- PubChem: 59472121
- DrugBank: DB11794
- ChEMBL: CHEMBL3989870
- CAS: 1232416-25-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Surabhi Talele, Wenjuan Zhang, Danielle M Burgenske, Minjee Kim, Afroz S Mohammad, Sonja Dragojevic, Shiv K Gupta, Ranjit S Bindra, Jann N Sarkaria, William F Elmquist. Brain Distribution of Berzosertib: An Ataxia Telangiectasia and Rad3-Related Protein Inhibitor for the Treatment of Glioblastoma.
The Journal of pharmacology and experimental therapeutics.
2021 12; 379(3):343-357. doi:
10.1124/jpet.121.000845. [PMID: 34556535] - Gustavo Garcia, Arun Sharma, Arunachalam Ramaiah, Chandani Sen, Arunima Purkayastha, Donald B Kohn, Mark S Parcells, Sebastian Beck, Heeyoung Kim, Malina A Bakowski, Melanie G Kirkpatrick, Laura Riva, Karen C Wolff, Brandon Han, Constance Yuen, David Ulmert, Prabhat K Purbey, Philip Scumpia, Nathan Beutler, Thomas F Rogers, Arnab K Chatterjee, Gülsah Gabriel, Ralf Bartenschlager, Brigitte Gomperts, Clive N Svendsen, Ulrich A K Betz, Robert D Damoiseaux, Vaithilingaraja Arumugaswami. Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication.
Cell reports.
2021 04; 35(1):108940. doi:
10.1016/j.celrep.2021.108940. [PMID: 33784499] - Nadia Terranova, Mendel Jansen, Martin Falk, Bart S Hendriks. Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types.
Cancer chemotherapy and pharmacology.
2021 02; 87(2):185-196. doi:
10.1007/s00280-020-04184-z. [PMID: 33145616] - Wenxiu Qi, Xiaohao Xu, Manying Wang, Xiangyan Li, Chaonan Wang, Liping Sun, Daqing Zhao, Liwei Sun. Inhibition of Wee1 sensitizes AML cells to ATR inhibitor VE-822-induced DNA damage and apoptosis.
Biochemical pharmacology.
2019 06; 164(?):273-282. doi:
10.1016/j.bcp.2019.04.022. [PMID: 31014753] - Brian F Kiesel, Jonas Scemama, Robert A Parise, Liza Villaruz, Andre Iffland, Austin Doyle, Percy Ivy, Edward Chu, Christopher J Bakkenist, Jan H Beumer. LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma.
Journal of pharmaceutical and biomedical analysis.
2017 Nov; 146(?):244-250. doi:
10.1016/j.jpba.2017.08.037. [PMID: 28888173] - Simon J A van Kuijk, Nanda Kumar Parvathaneni, Raymon Niemans, Marike W van Gisbergen, Fabrizio Carta, Daniela Vullo, Silvia Pastorekova, Ala Yaromina, Claudiu T Supuran, Ludwig J Dubois, Jean-Yves Winum, Philippe Lambin. New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.
European journal of medicinal chemistry.
2017 Feb; 127(?):691-702. doi:
10.1016/j.ejmech.2016.10.037. [PMID: 27823879]