Cc-223 (BioDeep_00000838021)

   


代谢物信息卡片


Cc-223

化学式: C21H27N5O3 (397.2113792)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C1=NC=C(C=C1)C2=CN=C3C(=N2)N(C(=O)CN3)C4CCC(CC4)OC)O
InChI: InChI=1S/C21H27N5O3/c1-21(2,28)17-9-4-13(10-22-17)16-11-23-19-20(25-16)26(18(27)12-24-19)14-5-7-15(29-3)8-6-14/h4,9-11,14-15,28H,5-8,12H2,1-3H3,(H,23,24)

描述信息

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2201 - mTOR Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
Onatasertib (CC-223) is a potent, selective, and orally bioavailable inhibitor of mTOR kinase, with an IC50 value for mTOR kinase of 16 nM. Onatasertib inhibits both mTORC1 and mTORC2.
Onatasertib (CC-223) is a potent, selective, and orally bioavailable inhibitor of mTOR kinase, with an IC50 value for mTOR kinase of 16 nM. Onatasertib inhibits both mTORC1 and mTORC2.

同义名列表

3 个代谢物同义名

Cc-223; ATG-008; Onatasertib



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zeen Tong, Christian Atsriku, Usha Yerramilli, Xiaomin Wang, Jim Nissel, Yan Li, Sekhar Surapaneni. Absorption, distribution, metabolism, and excretion of mTOR kinase inhibitor CC-223 in rats, dogs, and humans. Xenobiotica; the fate of foreign compounds in biological systems. 2019 Jan; 49(1):43-53. doi: 10.1080/00498254.2017.1413718. [PMID: 29206565]
  • Denise Rageot, Thomas Bohnacker, Anna Melone, Jean-Baptiste Langlois, Chiara Borsari, Petra Hillmann, Alexander M Sele, Florent Beaufils, Marketa Zvelebil, Paul Hebeisen, Wolfgang Löscher, John Burke, Doriano Fabbro, Matthias P Wymann. Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders. Journal of medicinal chemistry. 2018 11; 61(22):10084-10105. doi: 10.1021/acs.jmedchem.8b01262. [PMID: 30359003]
  • Deborah S Mortensen, Sophie M Perrin-Ninkovic, Graziella Shevlin, Jingjing Zhao, Garrick Packard, Sogole Bahmanyar, Matthew Correa, Jan Elsner, Roy Harris, Branden G S Lee, Patrick Papa, Jason S Parnes, Jennifer R Riggs, John Sapienza, Lida Tehrani, Brandon Whitefield, Julius Apuy, René R Bisonette, James C Gamez, Matt Hickman, Godrej Khambatta, Jim Leisten, Sophie X Peng, Samantha J Richardson, Brian E Cathers, Stacie S Canan, Mehran F Moghaddam, Heather K Raymon, Peter Worland, Rama Krishna Narla, Kimberly E Fultz, Sabita Sankar. Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223. Journal of medicinal chemistry. 2015 Jul; 58(13):5323-33. doi: 10.1021/acs.jmedchem.5b00626. [PMID: 26083478]
  • Deborah S Mortensen, Sophie M Perrin-Ninkovic, Roy Harris, Branden G S Lee, Graziella Shevlin, Matt Hickman, Gody Khambatta, Rene R Bisonette, Kimberly E Fultz, Sabita Sankar. Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors. Bioorganic & medicinal chemistry letters. 2011 Nov; 21(22):6793-9. doi: 10.1016/j.bmcl.2011.09.035. [PMID: 21978683]