Repinotan (BioDeep_00000838019)
代谢物信息卡片
化学式: C21H24N2O4S (400.1457)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2=CC=CC=C2OC1CNCCCCN3C(=O)C4=CC=CC=C4S3(=O)=O
InChI: InChI=1S/C21H24N2O4S/c24-21-18-8-2-4-10-20(18)28(25,26)23(21)14-6-5-13-22-15-17-12-11-16-7-1-3-9-19(16)27-17/h1-4,7-10,17,22H,5-6,11-15H2/t17-/m1/s1
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ulf Guenther, Nils U Theuerkauf, Daniel Huse, Michael F Boettcher, Georg Wensing, Christian Putensen, Andreas Hoeft. Selective 5-HT(1A)-R-agonist repinotan prevents remifentanil-induced ventilatory depression and prolongs antinociception.
Anesthesiology.
2012 Jan; 116(1):56-64. doi:
10.1097/aln.0b013e31823d08fa. [PMID: 22082683] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Takahiko Tanigawa, Roland Heinig, Yoshihiro Kuroki, Shun Higuchi. Evaluation of interethnic differences in repinotan pharmacokinetics by using population approach.
Drug metabolism and pharmacokinetics.
2006 Feb; 21(1):61-9. doi:
10.2133/dmpk.21.61. [PMID: 16547395] - José M Ferro, Antoni Dávalos. Other neuroprotective therapies on trial in acute stroke.
Cerebrovascular diseases (Basel, Switzerland).
2006; 21 Suppl 2(?):127-30. doi:
10.1159/000091712. [PMID: 16651823] - Thomas Schwarz, Bernhard Beckermann, Klaus Buehner, Frank Mauler, Joachim Schuhmacher, Dietrich Seidel, Wolfram Steinke, Corinna Weinz, Dieter Zimmerd. Pharmacokinetics of repinotan in healthy and brain injured animals.
Biopharmaceutics & drug disposition.
2005 Sep; 26(6):259-68. doi:
10.1002/bdd.458. [PMID: 15966026] - Roland Heinig, Michael F Böttcher. Pharmacokinetics of escalating doses of intravenous repinotan in healthy male volunteers.
Clinical drug investigation.
2005; 25(2):115-23. doi:
10.2165/00044011-200525020-00004. [PMID: 17523761] - Roland Heinig, Pavur Sundaresan, Anita Shah, Michael Boettcher. Effect of gender and age on the pharmacokinetics of repinotan.
Clinical drug investigation.
2005; 25(2):125-34. doi:
10.2165/00044011-200525020-00005. [PMID: 17523762] - B Ahlemeyer, H Beier, I Semkova, C Schaper, J Krieglstein. S-100beta protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT(1A)-receptor agonist, Bay x 3702.
Brain research.
2000 Mar; 858(1):121-8. doi:
10.1016/s0006-8993(99)02438-5. [PMID: 10700604] - B Ahlemeyer, A Glaser, C Schaper, I Semkova, J Krieglstein. The 5-HT1A receptor agonist Bay x 3702 inhibits apoptosis induced by serum deprivation in cultured neurons.
European journal of pharmacology.
1999 Apr; 370(2):211-6. doi:
10.1016/s0014-2999(99)00136-3. [PMID: 10323272] - J De Vry, R Schohe-Loop, H G Heine, J M Greuel, F Mauler, B Schmidt, H Sommermeyer, T Glaser. Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist.
The Journal of pharmacology and experimental therapeutics.
1998 Mar; 284(3):1082-94. doi:
NULL. [PMID: 9495870]
