Irosustat (BioDeep_00000837993)
代谢物信息卡片
Irosustat
化学式: C14H15NO5S (309.06709)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC2=C(CC1)C(=O)OC3=C2C=CC(=C3)OS(=O)(=O)N
InChI: InChI=1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18)
描述信息
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
C471 - Enzyme Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D09915
- PubChem: 5287541
- DrugBank: DB02292
- ChEMBL: CHEMBL286738
- CAS: 288628-05-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dehong Li, Yingjie Wen, Ziyue Ou, Ye Yu, Chen Zhao, Fei Lin, Hanhong Xu. Inhibitor of Glucosinolate Sulfatases as a Potential Friendly Insecticide to Control Plutella xylostella.
Journal of agricultural and food chemistry.
2022 Oct; 70(42):13528-13537. doi:
10.1021/acs.jafc.2c04542. [PMID: 36251030] - Mohammed I El-Gamal, Seyed-Omar Zaraei, Paul A Foster, Hanan S Anbar, Randa El-Gamal, Raafat El-Awady, Barry V L Potter. A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation.
Bioorganic & medicinal chemistry.
2020 04; 28(8):115406. doi:
10.1016/j.bmc.2020.115406. [PMID: 32173116] - Ye Feng, Yang Xie, Meishu Xu, Linhao Li, Kyle W Selcer, Patrick J Oberly, Samuel M Poloyac, Hongbing Wang, Chengjiang Li, Fengqin Dong, Chaohui Yu, Wen Xie. Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice.
The Journal of biological chemistry.
2019 08; 294(32):12112-12121. doi:
10.1074/jbc.ra119.009181. [PMID: 31217279] - Frank Giton, Nanor Sirab, Grégory Franck, Marianne Gervais, Fabien Schmidlin, Tauhid Ali, Yves Allory, Alexandre de la Taille, Francis Vacherot, Sylvain Loric, Jean Fiet. Evidence of estrone-sulfate uptake modification in young and middle-aged rat prostate.
The Journal of steroid biochemistry and molecular biology.
2015 Aug; 152(?):89-100. doi:
10.1016/j.jsbmb.2015.05.002. [PMID: 25958048] - Zinnia P Parra-Guillen, Josep María Cendrós Carreras, Concepción Peraire, Rosendo Obach, Joan Prunynosa, Eric Chetaille, Iñaki F Trocóniz. Population pharmacokinetic modelling of irosustat in postmenopausal women with oestrogen-receptor positive breast cancer incorporating non-linear red blood cell uptake.
Pharmaceutical research.
2015 Apr; 32(4):1493-504. doi:
10.1007/s11095-014-1555-4. [PMID: 25355461] - Verònica Ventura, Josep Solà, Concepción Peraire, Françoise Brée, Rosendo Obach. In vitro evaluation of the interaction potential of irosustat with drug-metabolizing enzymes.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jul; 40(7):1268-78. doi:
10.1124/dmd.111.044271. [PMID: 22451700] - L W Lawrence Woo, Toby Jackson, Aurélien Putey, Gyles Cozier, Philip Leonard, K Ravi Acharya, Surinder K Chander, Atul Purohit, Michael J Reed, Barry V L Potter. Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.
Journal of medicinal chemistry.
2010 Mar; 53(5):2155-70. doi:
10.1021/jm901705h. [PMID: 20148564] - Paul A Foster, Surinder K Chander, Michael F C Parsons, Simon P Newman, L W Lawrence Woo, Barry V L Potter, Michael J Reed, Atul Purohit. Efficacy of three potent steroid sulfatase inhibitors: pre-clinical investigations for their use in the treatment of hormone-dependent breast cancer.
Breast cancer research and treatment.
2008 Sep; 111(1):129-38. doi:
10.1007/s10549-007-9769-3. [PMID: 17914670] - Paul A Foster, L W Lawrence Woo, Barry V L Potter, Michael J Reed, Atul Purohit. The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer.
Endocrinology.
2008 Aug; 149(8):4035-42. doi:
10.1210/en.2008-0223. [PMID: 18450955] - S J Stanway, A Purohit, M J Reed. Measurement of estrone sulfate in postmenopausal women: comparison of direct RIA and GC-MS/MS methods for monitoring response to endocrine therapy in women with breast cancer.
Anticancer research.
2007 Jul; 27(4C):2765-7. doi:
NULL. [PMID: 17695445] - Susannah J Stanway, Patrick Delavault, Atul Purohit, L W Lawrence Woo, Christophe Thurieau, Barry V L Potter, Michael J Reed. Steroid sulfatase: a new target for the endocrine therapy of breast cancer.
The oncologist.
2007 Apr; 12(4):370-4. doi:
10.1634/theoncologist.12-4-370. [PMID: 17470679] - Susannah J Stanway, Atul Purohit, L W Lawrence Woo, Saulat Sufi, David Vigushin, Rebecca Ward, Richard H Wilson, Frank Z Stanczyk, Nicola Dobbs, Elena Kulinskaya, Moira Elliott, Barry V L Potter, Michael J Reed, R Charles Coombes. Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2006 Mar; 12(5):1585-92. doi:
10.1158/1078-0432.ccr-05-1996. [PMID: 16533785] - Matthew D Lloyd, Richard L Pederick, Ramanathan Natesh, L W Lawrence Woo, Atul Purohit, Michael J Reed, K Ravi Acharya, Barry V L Potter. Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent.
The Biochemical journal.
2005 Feb; 385(Pt 3):715-20. doi:
10.1042/bj20041037. [PMID: 15453828] - C R Ireson, S K Chander, A Purohit, D C Parish, L W L Woo, B V L Potter, M J Reed. Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats.
British journal of cancer.
2004 Oct; 91(7):1399-404. doi:
10.1038/sj.bjc.6602130. [PMID: 15328524] - Christopher R Ireson, David Parish, Atul Purohit, Lawrence W L Woo, Barry V L Potter, Surinder K Chander, Michael J Reed. Development of a sensitive high-performance liquid chromatography method for the detection of 667 COUMATE in vivo.
The Journal of steroid biochemistry and molecular biology.
2003 Feb; 84(2-3):337-42. doi:
10.1016/s0960-0760(03)00047-5. [PMID: 12711020]
