Amdoxovir (BioDeep_00000837990)
代谢物信息卡片
化学式: C9H12N6O3 (252.0970842)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(OC(O1)CO)N2C=NC3=C(N=C(N=C32)N)N
InChI: InChI=1S/C9H12N6O3/c10-7-6-8(14-9(11)13-7)15(3-12-6)4-2-17-5(1-16)18-4/h3-5,16H,1-2H2,(H4,10,11,13,14)/t4-,5-/m1/s1
描述信息
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D02890
- PubChem: 124088
- DrugBank: DB06619
- ChEMBL: CHEMBL458876
- CAS: 145514-04-1
- CAS: 153611-19-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Selwyn J Hurwitz, Ghazia Asif, Emilie Fromentin, Phillip M Tharnish, Raymond F Schinazi. Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals.
Antimicrobial agents and chemotherapy.
2010 Mar; 54(3):1248-55. doi:
10.1128/aac.01209-09
. [PMID: 20038617] - Robert L Murphy, Nancy M Kivel, Carlos Zala, Claudia Ochoa, Phillip Tharnish, Judy Mathew, Maria Luz Pascual, Raymond F Schinazi. Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV-1-infected individuals.
Antiviral therapy.
2010; 15(2):185-92. doi:
10.3851/imp1514
. [PMID: 20386073] - Emilie Fromentin, Ghazia Asif, Aleksandr Obikhod, Selwyn J Hurwitz, Raymond F Schinazi. Simultaneous quantification of 9-(beta-D-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography-tandem mass spectrometric assay.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Nov; 877(29):3482-8. doi:
10.1016/j.jchromb.2009.08.030
. [PMID: 19740712] - Stephan Menne, Ghazia Asif, Jannan Narayanasamy, Scott D Butler, Andrea L George, Selwyn J Hurwitz, Raymond F Schinazi, Chung K Chu, Paul J Cote, John L Gerin, Bud C Tennant. Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection.
Antimicrobial agents and chemotherapy.
2007 Sep; 51(9):3177-84. doi:
10.1128/aac.00325-07
. [PMID: 17606676] - Ghazia Asif, Selwyn J Hurwitz, Aleksandr Obikhod, David Delinsky, Janarthanan Narayanasamy, Chung K Chu, Harold M McClure, Raymond F Schinazi. Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys.
Antimicrobial agents and chemotherapy.
2007 Jul; 51(7):2424-9. doi:
10.1128/aac.01498-06
. [PMID: 17485498] - Barbara M Gripshover, Heather Ribaudo, Jorge Santana, John G Gerber, Thomas B Campbell, Evelyn Hogg, Bernadette Jarocki, Scott M Hammer, Daniel R Kuritzkes. Amdoxovir versus placebo with enfuvirtide plus optimized background therapy for HIV-1-infected subjects failing current therapy (AACTG A5118).
Antiviral therapy.
2006; 11(5):619-23. doi:
NULL
. [PMID: 16964830] - Melanie A Thompson, Harold A Kessler, Joseph J Eron, Jeffrey M Jacobson, Nathalie Adda, Gong Shen, Jian Zong, Jeanette Harris, Cary Moxham, Franck S Rousseau. Short-term safety and pharmacodynamics of amdoxovir in HIV-infected patients.
AIDS (London, England).
2005 Oct; 19(15):1607-15. doi:
10.1097/01.aids.0000186822.68606.05
. [PMID: 16184030] - Erik De Clercq. HIV-chemotherapy and -prophylaxis: new drugs, leads and approaches.
The international journal of biochemistry & cell biology.
2004 Sep; 36(9):1800-22. doi:
10.1016/j.biocel.2004.02.015
. [PMID: 15183346] - S Dominguez, F Bricaire. [Antiretroviral therapies].
Presse medicale (Paris, France : 1983).
2000 Dec; 29(37):2065-8. doi:
"
. [PMID: 11155737] - H Chen, R F Schinazi, P Rajagopalan, Z Gao, C K Chu, H M McClure, F D Boudinot. Pharmacokinetics of (-)-beta-D-dioxolane guanine and prodrug (-)-beta-D-2,6-diaminopurine dioxolane in rats and monkeys.
AIDS research and human retroviruses.
1999 Dec; 15(18):1625-30. doi:
10.1089/088922299309667
. [PMID: 10606085] - P Rajagopalan, Z Gao, C K Chu, R F Schinazi, H M McClure, F D Boudinot. High-performance liquid chromatographic determination of (-)-beta-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, using ultraviolet and on-line radiochemical detection.
Journal of chromatography. B, Biomedical applications.
1995 Oct; 672(1):119-24. doi:
10.1016/0378-4347(95)00197-q
. [PMID: 8590923]