Mirogabalin (BioDeep_00000837977)
代谢物信息卡片
化学式: C12H19NO2 (209.1415714)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1=CC2C(C1)CC2(CC(=O)O)CN
InChI: InChI=1S/C12H19NO2/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15)/t9-,10-,12-/m1/s1
描述信息
N - Nervous system > N02 - Analgesics > N02B - Other analgesics and antipyretics > N02BF - Gabapentinoids
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D11203
- PubChem: 59509752
- DrugBank: DB11825
- ChEMBL: CHEMBL3545125
- CAS: 1138245-13-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Li-Mian Hong, Jian-Min Liu, Lei Lin, Chun-Chun Huang, Rui Chen, Wei-Wei Lin. Modeling an evaluation of the efficacy of the novel neuroanalgesic drug mirogabalin for diabetic peripheral neuropathic pain and postherpetic neuralgia therapy.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2024 Jun; 197(?):106777. doi:
10.1016/j.ejps.2024.106777. [PMID: 38649099] - Naotoshi Yamamura, Minoru Uchiyama, Makoto Takahashi, Tomoyo Honda, Yumi Nishiya. Pharmacokinetics and metabolism of mirogabalin, a novel α2δ ligand, in rats and monkeys.
Xenobiotica; the fate of foreign compounds in biological systems.
2022 Jan; 52(1):54-64. doi:
10.1080/00498254.2022.2049396. [PMID: 35249464] - Naotoshi Yamamura, Jeanne Mendel-Harary, Karen Brown, Minoru Uchiyama, Yoko Urasaki, Makoto Takahashi, Vance Warren, Vijay Vashi. Metabolism, excretion, and pharmacokinetics of [14C]mirogabalin, a novel α2δ ligand, in healthy volunteers following oral administration.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 May; 51(5):549-563. doi:
10.1080/00498254.2021.1879408. [PMID: 33487061] - Yutaka Kitano, Kiyonori Kai, Naotoshi Yamamura, Satoshi Yoshiba, Masanori Kuroha. [Pharmacological, pharmacodynamics, and clinical profile of mirogabalin besylate (Tarlige® tablets 2.5 mg∙5 mg∙10 mg∙15 mg)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2019; 154(6):352-361. doi:
10.1254/fpj.154.352. [PMID: 31787689] - James Dow, Alexander Currie, Ling He, Faisal Zaidi, Hamim Zahir. Effect of coadministration of metformin with mirogabalin: Results from a phase 1, randomized, open-label, drug-drug interaction study
.
International journal of clinical pharmacology and therapeutics.
2018 Oct; 56(10):451-458. doi:
10.5414/cp203185. [PMID: 30049303] - Karen Brown, Jeanne Mendell, Shoichi Ohwada, Ching Hsu, Ling He, Vance Warren, Victor Dishy, Hamim Zahir. Tolerability, pharmacokinetics, and pharmacodynamics of mirogabalin in healthy subjects: Results from phase 1 studies.
Pharmacology research & perspectives.
2018 10; 6(5):e00418. doi:
10.1002/prp2.418. [PMID: 30151212] - Mendel Jansen, Steven Warrington, Victor Dishy, Shoichi Ohwada, Lisa Johnson, Karen Brown, Hitoshi Ishizuka. A Randomized, Placebo-Controlled, Double-Blind Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Repeated Doses of Mirogabalin in Healthy Asian Volunteers.
Clinical pharmacology in drug development.
2018 08; 7(6):661-669. doi:
10.1002/cpdd.448. [PMID: 29663714] - Manabu Kato, Naoyuki Tajima, Takako Shimizu, Masahiro Sugihara, Kenichi Furihata, Kazuhiro Harada, Hitoshi Ishizuka. Pharmacokinetics and Safety of a Single Oral Dose of Mirogabalin in Japanese Subjects With Varying Degrees of Renal Impairment.
Journal of clinical pharmacology.
2018 Jan; 58(1):57-63. doi:
10.1002/jcph.974. [PMID: 28834546] - Ophelia Q P Yin, Domenico Merante, Kenneth Truitt, Raymond Miller. Population pharmacokinetic modeling and simulation for assessing renal impairment effect on the pharmacokinetics of mirogabalin.
Journal of clinical pharmacology.
2016 Feb; 56(2):203-12. doi:
10.1002/jcph.584. [PMID: 26138993]