Phenol, 4-((4-(((2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl)methoxy)-2,6-dimethylphenyl)methyl)-2-(1-methylethyl)- (BioDeep_00000837926)
代谢物信息卡片
化学式: C28H32ClO5P (514.1675782)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=CC(=C1CC2=CC(=C(C=C2)O)C(C)C)C)OCP3(=O)OCCC(O3)C4=CC(=CC=C4)Cl
InChI: InChI=1S/C28H32ClO5P/c1-18(2)25-14-21(8-9-27(25)30)15-26-19(3)12-24(13-20(26)4)32-17-35(31)33-11-10-28(34-35)22-6-5-7-23(29)16-22/h5-9,12-14,16,18,28,30H,10-11,15,17H2,1-4H3/t28-,35+/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Eva K Wirth, Tobias Puengel, Joachim Spranger, Frank Tacke. Thyroid hormones as a disease modifier and therapeutic target in nonalcoholic steatohepatitis.
Expert review of endocrinology & metabolism.
2022 09; 17(5):425-434. doi:
10.1080/17446651.2022.2110864. [PMID: 35957531] - Maria Coppola, Daniela Glinni, Maria Moreno, Federica Cioffi, Elena Silvestri, Fernando Goglia. Thyroid hormone analogues and derivatives: Actions in fatty liver.
World journal of hepatology.
2014 Mar; 6(3):114-29. doi:
10.4254/wjh.v6.i3.114. [PMID: 24672641] - Ivan Tancevski, Philipp Eller, Josef R Patsch, Andreas Ritsch. The resurgence of thyromimetics as lipid-modifying agents.
Current opinion in investigational drugs (London, England : 2000).
2009 Sep; 10(9):912-8. doi:
NULL. [PMID: 19705333] - B R Ito, B-H Zhang, E E Cable, X Song, J M Fujitaki, D A MacKenna, C E Wilker, B Chi, P D van Poelje, D L Linemeyer, M D Erion. Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys.
British journal of pharmacology.
2009 Feb; 156(3):454-65. doi:
10.1111/j.1750-3639.2009.00038.x. [PMID: 19183199] - Serge H Boyer, Hongjian Jiang, Jason D Jacintho, Mali Venkat Reddy, Haiqing Li, Wenyu Li, Jennifer L Godwin, William G Schulz, Edward E Cable, Jinzhao Hou, Rongrong Wu, James M Fujitaki, Scott J Hecker, Mark D Erion. Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs.
Journal of medicinal chemistry.
2008 Nov; 51(22):7075-93. doi:
10.1021/jm800824d. [PMID: 18975928] - James M Fujitaki, Edward E Cable, Bruce R Ito, Bao-Hong Zhang, Jinzhao Hou, Chun Yang, David A Bullough, James L Ferrero, Paul D van Poelje, David L Linemeyer, Mark D Erion. Preclinical pharmacokinetics of a HepDirect prodrug of a novel phosphonate-containing thyroid hormone receptor agonist.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Nov; 36(11):2393-403. doi:
10.1124/dmd.108.021642. [PMID: 18703645] - Mark D Erion, Edward E Cable, Bruce R Ito, Hongjian Jiang, James M Fujitaki, Patricia D Finn, Bao-Hong Zhang, Jinzhao Hou, Serge H Boyer, Paul D van Poelje, David L Linemeyer. Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index.
Proceedings of the National Academy of Sciences of the United States of America.
2007 Sep; 104(39):15490-5. doi:
10.1073/pnas.0702759104. [PMID: 17878314]