Phosphomethylphosphonic acid adenosyl ester (BioDeep_00000837924)

   


代谢物信息卡片


Phosphomethylphosphonic acid adenosyl ester

化学式: C11H17N5O9P2 (425.0501492)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(CP(=O)(O)O)O)O)O)N
InChI: InChI=1S/C11H17N5O9P2/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1

描述信息

D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

Phosphomethylphosphonic acid adenosyl ester



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anna Junker, Christian Renn, Clemens Dobelmann, Vigneshwaran Namasivayam, Shanu Jain, Karolina Losenkova, Heikki Irjala, Sierra Duca, Ramachandran Balasubramanian, Saibal Chakraborty, Frederik Börgel, Herbert Zimmermann, Gennady G Yegutkin, Christa E Müller, Kenneth A Jacobson. Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors. Journal of medicinal chemistry. 2019 04; 62(7):3677-3695. doi: 10.1021/acs.jmedchem.9b00164. [PMID: 30895781]
  • Marta Tomczyk, Paulina Mierzejewska, Ewa M Slominska, Ryszard T Smolenski. The metabolism of ecto-5'-nucleotidase (CD73) inhibitor-α,β-methylene adenosine diphosphate in BALB/c mice. Nucleosides, nucleotides & nucleic acids. 2018; 37(12):709-716. doi: 10.1080/15257770.2018.1489052. [PMID: 30623751]
  • Mihwa Kim, Ahrom Ham, Katelyn Yu-Mi Kim, Kevin M Brown, H Thomas Lee. The volatile anesthetic isoflurane increases endothelial adenosine generation via microparticle ecto-5'-nucleotidase (CD73) release. PloS one. 2014; 9(6):e99950. doi: 10.1371/journal.pone.0099950. [PMID: 24945528]
  • Liliana Rockenbach, Luci Bavaresco, Patrícia Fernandes Farias, Angélica Regina Cappellari, Carlos Henrique Barrios, Fernanda Bueno Morrone, Ana Maria Oliveira Battastini. Alterations in the extracellular catabolism of nucleotides are involved in the antiproliferative effect of quercetin in human bladder cancer T24 cells. Urologic oncology. 2013 Oct; 31(7):1204-11. doi: 10.1016/j.urolonc.2011.10.009. [PMID: 22137869]
  • Edwin K Jackson, Delbert G Gillespie. Extracellular 2',3'-cAMP-adenosine pathway in proximal tubular, thick ascending limb, and collecting duct epithelial cells. American journal of physiology. Renal physiology. 2013 Jan; 304(1):F49-55. doi: 10.1152/ajprenal.00571.2012. [PMID: 23077101]
  • Theresa Pang, Xiaohong Tracey Gan, David J Freeman, Michael A Cook, Morris Karmazyn. Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes. American journal of physiology. Heart and circulatory physiology. 2010 Feb; 298(2):H545-53. doi: 10.1152/ajpheart.00417.2009. [PMID: 19966059]
  • Camilla Mohlin, Susanne Säve, Mikael Nilsson, Katarina Persson. Studies of the extracellular ATP-adenosine pathway in human urinary tract epithelial cells. Pharmacology. 2009; 84(4):196-202. doi: 10.1159/000235908. [PMID: 19729987]
  • Almut Grenz, Hua Zhang, Jochen Weingart, Simone von Wietersheim, Tobias Eckle, Juergen Schnermann, Christoph Köhle, Doris Kloor, Christoph H Gleiter, Volker Vallon, Holger K Eltzschig, Hartmut Osswald. Lack of effect of extracellular adenosine generation and signaling on renal erythropoietin secretion during hypoxia. American journal of physiology. Renal physiology. 2007 Nov; 293(5):F1501-11. doi: 10.1152/ajprenal.00243.2007. [PMID: 17855480]
  • J Karczewska, L Martyniec, G Dzierzko, J Stepiński, S Angielski. The relationship between constitutive ATP release and its extracellular metabolism in isolated rat kidney glomeruli. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2007 Jun; 58(2):321-33. doi: . [PMID: 17622700]
  • Svetlana T Mihaylova-Todorova, Latchezar D Todorov, David P Westfall. Enzyme kinetics and pharmacological characterization of nucleotidases released from the guinea pig isolated vas deferens during nerve stimulation: evidence for a soluble ecto-nucleoside triphosphate diphosphohydrolase-like ATPase and a soluble ecto-5'-nucleotidase-like AMPase. The Journal of pharmacology and experimental therapeutics. 2002 Sep; 302(3):992-1001. doi: 10.1124/jpet.102.033332. [PMID: 12183656]
  • Y F Chen, P L Li, A P Zou. Oxidative stress enhances the production and actions of adenosine in the kidney. American journal of physiology. Regulatory, integrative and comparative physiology. 2001 Dec; 281(6):R1808-16. doi: 10.1152/ajpregu.2001.281.6.r1808. [PMID: 11705765]
  • T Miki, T Miura, R Bünger, K Suzuki, J Sakamoto, K Shimamoto. Ecto-5'-nucleotidase is not required for ischemic preconditioning in rabbit myocardium in situ. The American journal of physiology. 1998 10; 275(4):H1329-37. doi: 10.1152/ajpheart.1998.275.4.h1329. [PMID: 9746483]
  • C H Gleiter, M Brause, U Delabar, H Zebski, K U Eckardt. Evidence against a major role of adenosine in oxygen-dependent regulation of erythropoietin in rats. Kidney international. 1997 Aug; 52(2):338-44. doi: 10.1038/ki.1997.339. [PMID: 9263988]
  • T A Schwann, K W Lobdell, J Braxton, S Condos, J C Baldwin, G S Kopf. 5'-Nucleotidase inhibition enhances postischemic myocardial performance. The Journal of surgical research. 1994 Apr; 56(4):356-60. doi: 10.1006/jsre.1994.1055. [PMID: 8152230]
  • R Fabiani, G Ronquist. Characteristics of membrane-bound 5'-nucleotidase on human prostasomes. Clinica chimica acta; international journal of clinical chemistry. 1993 Jul; 216(1-2):175-82. doi: 10.1016/0009-8981(93)90150-3. [PMID: 8222268]
  • K M Gaudio, G Thulin, T Ardito, M Kashgarian, N J Siegel. Redistribution of cellular energy following renal ischemia. Pediatric nephrology (Berlin, Germany). 1991 Sep; 5(5):591-6. doi: 10.1007/bf00856647. [PMID: 1911145]
  • K Flocke, H G Mannherz. Isolation and characterization of 5'-nucleotidase of a human pancreatic tumor cell line. Biochimica et biophysica acta. 1991 Jan; 1076(2):273-81. doi: 10.1016/0167-4838(91)90278-8. [PMID: 1998727]
  • J C Shryock, M T Boykin, J A Hill, L Belardinelli. A new method of sampling blood for measurement of plasma adenosine. The American journal of physiology. 1990 Apr; 258(4 Pt 2):H1232-9. doi: 10.1152/ajpheart.1990.258.4.h1232. [PMID: 2331011]
  • G H Möser, J Schrader, A Deussen. Turnover of adenosine in plasma of human and dog blood. The American journal of physiology. 1989 Apr; 256(4 Pt 1):C799-806. doi: 10.1152/ajpcell.1989.256.4.c799. [PMID: 2539728]
  • A Van Waarde, M E Stromski, G Thulin, K M Gaudio, M Kashgarian, R G Shulman, N J Siegel. Protection of the kidney against ischemic injury by inhibition of 5'-nucleotidase. The American journal of physiology. 1989 Feb; 256(2 Pt 2):F298-305. doi: 10.1152/ajprenal.1989.256.2.f298. [PMID: 2537026]
  • M Le Hir, R Gandhi, U C Dubach. Purification and properties of a 5'-nucleotidase from rat renal membranes. Enzyme. 1989; 41(2):87-93. doi: 10.1159/000469058. [PMID: 2539994]
  • M Massaia, A Pileri, M Boccadoro, A Bianchi, A Palumbo, U Dianzani. The generation of alloreactive cytotoxic T lymphocytes requires the expression of ecto-5'nucleotidase activity. Journal of immunology (Baltimore, Md. : 1950). 1988 Dec; 141(11):3768-75. doi: NULL. [PMID: 2846693]
  • B D Fuchs, M W Gorman, H V Sparks. Adenosine release into venous plasma during free flow exercise. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1986 Mar; 181(3):364-70. doi: 10.3181/00379727-181-42266. [PMID: 3814246]
  • H J Steinfelder, H G Joost. The inhibition of rat adipocyte ecto-5'-nucleotidase by xanthines is not related to lipolysis. Biochemical pharmacology. 1986 Mar; 35(5):867-9. doi: 10.1016/0006-2952(86)90257-1. [PMID: 3006694]
  • F L Belloni, P L Elkin, B Giannotto. The mechanism of adenosine release from hypoxic rat liver cells. British journal of pharmacology. 1985 Jun; 85(2):441-6. doi: 10.1111/j.1476-5381.1985.tb08880.x. [PMID: 4027478]
  • Y Naito, J M Lowenstein. 5'-Nucleotidase from rat heart membranes. Inhibition by adenine nucleotides and related compounds. The Biochemical journal. 1985 Mar; 226(3):645-51. doi: 10.1042/bj2260645. [PMID: 2985044]
  • N L Edwards, D Recker, J Manfredi, R Rembecki, I H Fox. Regulation of purine metabolism by plasma membrane and cytoplasmic 5'-nucleotidases. The American journal of physiology. 1982 Nov; 243(5):C270-7. doi: 10.1152/ajpcell.1982.243.5.c270. [PMID: 6291401]
  • A Zachowski, G Simonin, J Aubry, P Pommier, S N Singh, M Potter, A Paraf. Plasma membrane enzymes in BALB/c lymphomas with either T or B cell properties, I. 5'-Nucleotidase. Journal of receptor research. 1981; 2(1):97-118. doi: 10.3109/10799898109038800. [PMID: 6270328]