Alcuronium (BioDeep_00000837912)

   


代谢物信息卡片


Alcuronium

化学式: C44H50N4O2+2 (666.3933559999999)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CC[N+]12CCC34C1CC(C(=CCO)C2)C5=CN6C7C(=CN(C53)C8=CC=CC=C48)C9CC1C7(CC[N+]1(CC9=CCO)CC=C)C1=CC=CC=C16
InChI: InChI=1S/C44H50N4O2/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2/q+2/b29-13-,30-14-,33-25-,34-26-/t31-,32-,39-,40-,41-,42-,43+,44+,47-,48-/m0/s1

描述信息

M - Musculo-skeletal system > M03 - Muscle relaxants > M03A - Muscle relaxants, peripherally acting agents > M03AA - Curare alkaloids
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D002491 - Central Nervous System Agents

同义名列表

1 个代谢物同义名

Alcuronium



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • D Katerere, O Parry. Pharmacological actions of Heteromorpha trifoliata ('dombwe') on rat isolated muscle preparations. The Central African journal of medicine. 2000 Jan; 46(1):9-13. doi: 10.4314/cajm.v46i1.8515. [PMID: 14674200]
  • R S Miller, G M Peterson, S McLean, C Möller. Effect of cardiopulmonary bypass on the plasma concentrations of fentanyl and alcuronium. Journal of clinical pharmacy and therapeutics. 1997 Jun; 22(3):197-205. doi: 10.1046/j.1365-2710.1997.94875948.x. [PMID: 9447475]
  • C Diefenbach, T Künzer, W Buzello, M Theisohn. Alcuronium: a pharmacodynamic and pharmacokinetic update. Anesthesia and analgesia. 1995 Feb; 80(2):373-7. doi: 10.1097/00000539-199502000-00029. [PMID: 7818127]
  • L M Weekes, J P Keneally, P H Goonetilleke, I M Ramzan. Pharmacokinetics of alcuronium in children with acyanotic and cyanotic cardiac disease undergoing cardiopulmonary bypass surgery. Paediatric anaesthesia. 1995; 5(6):369-74. doi: 10.1111/j.1460-9592.1995.tb00329.x. [PMID: 8597969]
  • T Künzer, C W Buzello, M Theisohn, C Diefenbach. Simple and rapid high-performance liquid chromatography method for the determination of alcuronium in human plasma and urine. Journal of chromatography. B, Biomedical applications. 1994 Feb; 653(1):63-8. doi: 10.1016/0378-4347(93)e0426-q. [PMID: 8012561]
  • J Watkins. Adverse reaction to neuromuscular blockers: frequency, investigation, and epidemiology. Acta anaesthesiologica Scandinavica. Supplementum. 1994; 102(?):6-10. doi: 10.1111/j.1399-6576.1994.tb04030.x. [PMID: 7976160]
  • J P Keneally, P H Goonetilleke, I M Ramzan. Delayed onset of alcuronium effect in children with cyanotic congenital heart disease. Anaesthesia and intensive care. 1993 Apr; 21(2):197-200. doi: 10.1177/0310057x9302100211. [PMID: 8517511]
  • J L Gueant, E Mata, B Monin, D A Moneret-Vautrin, L Kamel, J P Nicolas, M C Laxenaire. Evaluation of a new reactive solid phase for radioimmunoassay of serum specific IgE against muscle relaxant drugs. Allergy. 1991 Aug; 46(6):452-8. doi: 10.1111/j.1398-9995.1991.tb04224.x. [PMID: 1957994]
  • T C Brown, M Gregory, B Bell, D Clare. Response to nondepolarizing muscle relaxants in children with tumours. Anaesthesia and intensive care. 1990 Nov; 18(4):460-5. doi: 10.1177/0310057x9001800407. [PMID: 2176439]
  • F deBros, R Okutani, E Inada, K Lawrence. Determination of alcuronium in plasma and urine by high-performance liquid chromatography. Journal of chromatography. 1990 Aug; 529(2):449-54. doi: 10.1016/s0378-4347(00)83853-0. [PMID: 2229263]
  • E S Assem. Naturally occurring IgG-antibody-like substance reacting with quaternary ammonium group and neuromuscular blockers: a common finding in humans and other species?. International archives of allergy and applied immunology. 1990; 91(4):426-30. doi: 10.1159/000235153. [PMID: 1698726]
  • R Okutani, K Kono, E Inada, D M Philbin. [Quantitative determination of alcuronium in plasma and urine by high pressure liquid chromatography using ultraviolet detection]. Masui. The Japanese journal of anesthesiology. 1988 Aug; 37(8):938-42. doi: NULL. [PMID: 3184444]
  • A Baraka, A N Sibai, M Hamed, R Delleh. Recurarisation following a suxamethonium-alcuronium sequence in patients with atypical cholinesterase. Anaesthesia. 1988 Apr; 43(4):310-1. doi: 10.1111/j.1365-2044.1988.tb08982.x. [PMID: 3377154]
  • D G Harle, B A Baldo. Structural features of potent inhibitors of rat kidney histamine N-methyltransferase. Biochemical pharmacology. 1988 Feb; 37(3):385-8. doi: 10.1016/0006-2952(88)90203-1. [PMID: 3337739]
  • A S Laurence. Serum myoglobin release following suxamethonium administration to children. European journal of anaesthesiology. 1988 Jan; 5(1):31-8. doi: NULL. [PMID: 3378554]
  • A S Lamont, M S Roberts, L J McLeod. Hypocarbia and muscle relaxant plasma levels. Anaesthesia and intensive care. 1987 Aug; 15(3):354-5. doi: NULL. [PMID: 3116880]
  • J S Walker, C A Shanks, C Borton, K F Brown. Alcuronium pharmacodynamics in dogs: effect-concentration relationships in the diaphragmatic and limb muscles. The Journal of pharmacy and pharmacology. 1987 Aug; 39(8):614-20. doi: 10.1111/j.2042-7158.1987.tb03439.x. [PMID: 2888852]
  • A S Laurence. Myalgia and biochemical changes following intermittent suxamethonium administration. Effects of alcuronium, lignocaine, midazolam and suxamethonium pretreatments on serum myoglobin, creatinine kinase and myalgia. Anaesthesia. 1987 May; 42(5):503-10. doi: 10.1111/j.1365-2044.1987.tb04042.x. [PMID: 3592177]
  • C L Smith, J M Hunter, R S Jones. Prolonged paralysis following an infusion of alcuronium in a patient with renal dysfunction. Anaesthesia. 1987 May; 42(5):522-5. doi: 10.1111/j.1365-2044.1987.tb04045.x. [PMID: 3592179]
  • S Oshita, H Tamura, T Masuda, S Fukuda, H Takeshita. Alcuronium pretreatment attenuates succinylcholine-induced increases in plasma catecholamine concentrations in humans. Anesthesia and analgesia. 1987 Apr; 66(4):314-6. doi: NULL. [PMID: 3565793]
  • D G Harle, B A Baldo, M M Fisher. Inhibition of histamine-N-methyltransferase activity by neuromuscular blocking drugs. Agents and actions. 1985 Oct; 17(1):27-31. doi: 10.1007/bf01966676. [PMID: 4083176]
  • A S Laurence. Biochemical changes following suxamethonium. Serum myoglobin, potassium and creatinine kinase changes before commencement of surgery. Anaesthesia. 1985 Sep; 40(9):854-9. doi: 10.1111/j.1365-2044.1985.tb11046.x. [PMID: 4051151]
  • J P Bradley, A R Marsland, J P O'Connor. Prolonged neuromuscular blockade after renal transplantation. Anaesthesia and intensive care. 1985 May; 13(2):196-8. doi: 10.1177/0310057x8501300215. [PMID: 3893211]
  • S Kaushik, V K Grover, H Singh, R V Yadav. Use of alcuronium in patients undergoing renal transplantation. British journal of anaesthesia. 1984 Nov; 56(11):1229-33. doi: 10.1093/bja/56.11.1229. [PMID: 6386020]
  • I D Stephens, P C Ho, A M Holloway, D W Bourne, E J Triggs. Pharmacokinetics of alcuronium in elderly patients undergoing total hip replacement or aortic reconstructive surgery. British journal of anaesthesia. 1984 May; 56(5):465-71. doi: 10.1093/bja/56.5.465. [PMID: 6721957]
  • M F Cummings, W J Russell, D B Frewin, W A Miller. The effects of gallamine and a mixture of pancuronium and alcuronium on the pressor and plasma catecholamine responses to tracheal intubation. Anaesthesia and intensive care. 1984 Feb; 12(1):22-6. doi: 10.1177/0310057x8401200105. [PMID: 6703312]
  • O Erkola, A Salmenperä, R Kuoppamäki. Five non-depolarizing muscle relaxants in precurarization. Acta anaesthesiologica Scandinavica. 1983 Dec; 27(6):427-32. doi: 10.1111/j.1399-6576.1983.tb01981.x. [PMID: 6141695]
  • B A Baldo, M M Fisher. Anaphylaxis to muscle relaxant drugs: cross-reactivity and molecular basis of binding of IgE antibodies detected by radioimmunoassay. Molecular immunology. 1983 Dec; 20(12):1393-400. doi: 10.1016/0161-5890(83)90171-2. [PMID: 6656781]
  • C Tovey, D W Bourne, J Schneider, I D Stephens, E J Triggs. Determination of alcuronium dichloride in plasma by high-performance liquid chromatography without solvent extraction. Journal of chromatography. 1983 Nov; 278(1):216-9. doi: 10.1016/s0378-4347(00)84778-7. [PMID: 6662884]
  • B A Baldo, M M Fisher. Detection of serum IgE antibodies that react with alcuronium and tubocurarine after life-threatening reactions to muscle-relaxant drugs. Anaesthesia and intensive care. 1983 Aug; 11(3):194-7. doi: 10.1177/0310057x8301100302. [PMID: 6614428]
  • M F Cummings, W J Russell, D B Frewin. Effects of pancuronium and alcuronium on the changes in arterial pressure and plasma catecholamine concentrations during tracheal intubation. British journal of anaesthesia. 1983 Jul; 55(7):619-23. doi: 10.1093/bja/55.7.619. [PMID: 6871054]
  • J S Walker, C Shanks, K F Brown. Alcuronium kinetics and plasma concentration-effect relationship. Clinical pharmacology and therapeutics. 1983 Apr; 33(4):510-6. doi: 10.1038/clpt.1983.69. [PMID: 6831830]
  • J S Walker, K F Brown, C A Shanks. Alcuronium kinetics in patients undergoing cardiopulmonary bypass surgery. British journal of clinical pharmacology. 1983 Feb; 15(2):237-44. doi: 10.1111/j.1365-2125.1983.tb01492.x. [PMID: 6601958]
  • P M Ertama. Histamine liberation in surgical patients following administration of neuromuscular blocking drugs. Annals of clinical research. 1982 Feb; 14(1):15-26. doi: NULL. [PMID: 6182834]
  • L Brandt, U Henneberg. [Does precurarization prevent the increase of serum potassium after administration of succinylcholine in risk patients? - a case report- (author's transl)]. Anasthesie, Intensivtherapie, Notfallmedizin. 1981 Dec; 16(6):353-5. doi: NULL. [PMID: 7325351]
  • J E Parkin. Determination of alcuronium chloride in biological fluids by high-performance liquid chromatography. Journal of chromatography. 1981 Sep; 225(1):240-4. doi: 10.1016/s0378-4347(00)80268-6. [PMID: 7298752]
  • P C Ho, I D Stephens, E J Triggs. Caesarean section and placental transfer of alcuronium. Anaesthesia and intensive care. 1981 May; 9(2):113-8. doi: 10.1177/0310057x8100900202. [PMID: 7258607]
  • N Iwatsuki, Y Hashimoto, K Amaha, S Obara, K Iwatsuki. Inotropic effects of non-depolarizing muscle relaxants in isolated canine heart muscle. Anesthesia and analgesia. 1980 Oct; 59(10):717-21. doi: NULL. [PMID: 6107062]
  • J Walker, C A Shanks, E J Triggs. Clinical pharmacokinetics of alcuronium chloride in man. European journal of clinical pharmacology. 1980 Jun; 17(6):449-57. doi: 10.1007/bf00570163. [PMID: 7398736]
  • M A Thompson. Muscle relaxant drugs. British journal of hospital medicine. 1980 Feb; 23(2):153-4, 163. doi: NULL. [PMID: 6102875]
  • D Balogh, A F Hammerle, H Hörtnagl, T Brücke, R Stadler-Wolffersgrün. [A comparative study on the effect of halothan-N2O-anaesthesia and neuroleptanalgesia on plasma catecholamines during the intra- and postoperative period (author's transl)]. Der Anaesthesist. 1979 Nov; 28(11):517-22. doi: NULL. [PMID: 525750]
  • D Cozanitis, E Haapanen. Studies on muscle relaxants during haemodialysis. Acta anaesthesiologica Scandinavica. 1979 Jun; 23(3):225-34. doi: 10.1111/j.1399-6576.1979.tb01444.x. [PMID: 484179]
  • W Abdulla, C Sostegno, R Frey, J Gärtner. [Behaviour of plasma-cortisol during ophthalmological operations in patients under electrostimulation anaesthesia (author's transl)]. Der Anaesthesist. 1979 May; 28(5):243-6. doi: NULL. [PMID: 380388]
  • F R Berry, D J Benson. Renal impairment and prolonged curarization. Anaesthesia and intensive care. 1979 May; 7(2):193. doi: NULL. [PMID: 159638]
  • W Abdulla, U Cordes, C Sostegno, J Beyer, R Frey, J Gärtner. [Plasma-catecholamines under electrostimulation and neurolept anaesthesia for retina and vitreous body operations (author's transl)]. Der Anaesthesist. 1979 May; 28(5):237-42. doi: NULL. [PMID: 380387]
  • J H Havill, A D Mee, M R Wallace, L S Chin, R P Rothwell. Prolonged curarisation in the presence of renal impairment. Anaesthesia and intensive care. 1978 Aug; 6(3):234-8. doi: 10.1177/0310057x7800600310. [PMID: 152588]
  • W Buzello, S Agoston. Comparative clinical pharmacokinetics of tubocurarine, gallamine, alcuronium and pancuronium. Der Anaesthesist. 1978 Jul; 27(7):313-8. doi: . [PMID: 150804]
  • W Buzello, S Agoston. Kinetics of intercompartmental disposition and excretion of tubocurarine, gallamine, alcuronium and pancuronium in patients with normal and impaired renal function. Der Anaesthesist. 1978 Jul; 27(7):319-21. doi: . [PMID: 150805]
  • J Heinonen, O Takkunen. Bradycardia during antagonism of pancuronium-induced neuromuscular block. British journal of anaesthesia. 1977 Nov; 49(11):1109-15. doi: 10.1093/bja/49.11.1109. [PMID: 588391]
  • M L Yeung. Plasma proteins, packed-cell volume and requirements for alcuronium. British journal of anaesthesia. 1976 Sep; 48(9):859-63. doi: 10.1093/bja/48.9.859. [PMID: 971391]
  • H C Niesel, I Münch. [Prolonged neuromuscular block following colistin (polymyxin E) (author's transl)]. Der Anaesthesist. 1974 Jul; 23(7):306-7. doi: NULL. [PMID: 4282009]