1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BioDeep_00000837910)

   


代谢物信息卡片


1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

化学式: C22H22N4O5 (422.1590122)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CN=C(C2=C1C(=CN2)C(=O)C(=O)N3CCN(CC3)C(=O)C4=CC=CC=C4)OC
InChI: InChI=1S/C22H22N4O5/c1-30-16-13-24-20(31-2)18-17(16)15(12-23-18)19(27)22(29)26-10-8-25(9-11-26)21(28)14-6-4-3-5-7-14/h3-7,12-13,23H,8-11H2,1-2H3

描述信息

D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D065147 - Viral Fusion Protein Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
D065147 - Viral Fusion Protein Inhibitors > D023581 - HIV Fusion Inhibitors

同义名列表

1 个代谢物同义名

1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione



数据库引用编号

5 个数据库交叉引用编号

分类词条

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代谢反应

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INOH(0)

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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文献列表

  • Linshuang Wang, Fengxue Qu, Xueyun Yu, Sixia Yang, Binbin Zhao, Yaojing Chen, Pengbo Li, Zhanjun Zhang, Junying Zhang, Xuejie Han, Dongfeng Wei. Cortical lipid metabolic pathway alteration of early Alzheimer's disease and candidate drugs screen. European journal of medical research. 2024 Mar; 29(1):199. doi: 10.1186/s40001-024-01730-w. [PMID: 38528586]
  • Tao Wang, Yasu Ueda, Zhongxing Zhang, Zhiwei Yin, John Matiskella, Bradley C Pearce, Zheng Yang, Ming Zheng, Dawn D Parker, Gregory A Yamanaka, Yi-Fei Gong, Hsu-Tso Ho, Richard J Colonno, David R Langley, Pin-Fang Lin, Nicholas A Meanwell, John F Kadow. Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir. Journal of medicinal chemistry. 2018 07; 61(14):6308-6327. doi: 10.1021/acs.jmedchem.8b00759. [PMID: 29920093]
  • Alicia Regueiro-Ren, Qiufen M Xue, Jacob J Swidorski, Yi-Fei Gong, Marina Mathew, Dawn D Parker, Zheng Yang, Betsy Eggers, Celia D'Arienzo, Yongnian Sun, Jacek Malinowski, Qi Gao, Dedong Wu, David R Langley, Richard J Colonno, Caly Chien, Dennis M Grasela, Ming Zheng, Pin-Fang Lin, Nicholas A Meanwell, John F Kadow. Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 12. Structure-activity relationships associated with 4-fluoro-6-azaindole derivatives leading to the identification of 1-(4-benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1h-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-585248). Journal of medicinal chemistry. 2013 Feb; 56(4):1656-69. doi: 10.1021/jm3016377. [PMID: 23360431]
  • George J Hanna, Jacob Lalezari, James A Hellinger, David A Wohl, Richard Nettles, Anna Persson, Mark Krystal, Pinfang Lin, Richard Colonno, Dennis M Grasela. Antiviral activity, pharmacokinetics, and safety of BMS-488043, a novel oral small-molecule HIV-1 attachment inhibitor, in HIV-1-infected subjects. Antimicrobial agents and chemotherapy. 2011 Feb; 55(2):722-8. doi: 10.1128/aac.00759-10. [PMID: 21078951]