Sp-Camps (BioDeep_00000837907)

   


代谢物信息卡片


Sp-Camps

化学式: C10H12N5O5PS (345.02967520000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C2C(C(C(O2)N3C=NC4=C(N=CN=C43)N)O)OP(=S)(O1)O
InChI: InChI=1S/C10H12N5O5PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13)/t4-,6-,7-,10-,21?/m1/s1

描述信息

D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors

同义名列表

1 个代谢物同义名

Sp-Camps



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Kiran L Sharma, Shuo Jia, Tasnim H Beacon, Ifeoluwa Adewumi, Camila López, Pingzhao Hu, Wayne Xu, James R Davie. Mitogen-induced transcriptional programming in human fibroblasts. Gene. 2021 Oct; 800(?):145842. doi: 10.1016/j.gene.2021.145842. [PMID: 34274479]
  • An-Rong Wang, Ming-Zhe Hu, Zhi-Lei Zhang, Ze-Yu Zhao, Yan-Bin Li, Bin Liu. Fastigial nucleus electrostimulation promotes axonal regeneration after experimental stroke via cAMP/PKA pathway. Neuroscience letters. 2019 04; 699(?):177-183. doi: 10.1016/j.neulet.2019.02.016. [PMID: 30753912]
  • Hye Rin Lee, Hwa Kyoung Shin, So Youn Park, Hye Young Kim, Won Suk Lee, Byung Yong Rhim, Ki Whan Hong, Chi Dae Kim. Cilostazol suppresses β-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-β. Journal of neuroscience research. 2014 Nov; 92(11):1581-90. doi: 10.1002/jnr.23421. [PMID: 24903973]
  • Peng Li, Hai-Jian Sun, Ying Han, Jue-Jin Wang, Feng Zhang, Chao-Shu Tang, Ye-Bo Zhou. Intermedin enhances sympathetic outflow via receptor-mediated cAMP/PKA signaling pathway in nucleus tractus solitarii of rats. Peptides. 2013 Sep; 47(?):1-6. doi: 10.1016/j.peptides.2013.05.002. [PMID: 23816795]
  • Ying Han, Hai-Jian Sun, Peng Li, Qing Gao, Ye-bo Zhou, Feng Zhang, Xing-Ya Gao, Guo-Qing Zhu. Angiotensin-(1-7) in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats. PloS one. 2012; 7(11):e48966. doi: 10.1371/journal.pone.0048966. [PMID: 23139827]
  • Jun Zhang, Scott F Walk, Kodi S Ravichandran, James C Garrison. Regulation of the Src homology 2 domain-containing inositol 5'-phosphatase (SHIP1) by the cyclic AMP-dependent protein kinase. The Journal of biological chemistry. 2009 Jul; 284(30):20070-8. doi: 10.1074/jbc.m109.016865. [PMID: 19494109]
  • Shawn M Crump, Robert N Correll, Elizabeth A Schroder, William C Lester, Brian S Finlin, Douglas A Andres, Jonathan Satin. L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. American journal of physiology. Heart and circulatory physiology. 2006 Oct; 291(4):H1959-71. doi: 10.1152/ajpheart.00956.2005. [PMID: 16648185]
  • Tammy L Awtry, Julie G Frank, Linda L Werling. In vitro regulation of serotonin transporter activity by protein kinase A and nicotinic acetylcholine receptors in the prefrontal cortex of rats. Synapse (New York, N.Y.). 2006 May; 59(6):342-9. doi: 10.1002/syn.20251. [PMID: 16463401]
  • Su-Jane Wang. An investigation into the effect of the type IV phosphodiesterase inhibitor rolipram in the modulation of glutamate release from rat prefrontocortical nerve terminals. Synapse (New York, N.Y.). 2006 Jan; 59(1):41-50. doi: 10.1002/syn.20212. [PMID: 16247764]
  • Rie Hosoi, Akira Matsumura, Shigekazu Mizokawa, Masaaki Tanaka, Fusao Nakamura, Kaoru Kobayashi, Yasuyoshi Watanabe, Osamu Inoue. MicroPET detection of enhanced 18F-FDG utilization by PKA inhibitor in awake rat brain. Brain research. 2005 Mar; 1039(1-2):199-202. doi: 10.1016/j.brainres.2005.01.064. [PMID: 15781062]
  • Kazuo Suzuki, Yuichi Oda, Kentaro Oda, Sinano Tanaka, Yukimi Sakaino, Takumi Matsudaira. Non-genomic action of 17beta-estradiol on opening of Ca(2+)- and voltage-activated K+ channel in lacrimal acinar cells. The Tokai journal of experimental and clinical medicine. 2004 Sep; 29(3):71-8. doi: NULL. [PMID: 15595464]
  • Anna-Louise M Cook, John M Haynes. Protein kinase G II-mediated proliferative effects in human cultured prostatic stromal cells. Cellular signalling. 2004 Feb; 16(2):253-61. doi: 10.1016/s0898-6568(03)00134-7. [PMID: 14636895]
  • Jeffrey Sprouse, Linda Reynolds, Xingfang Li, John Braselton, Anne Schmidt. 8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production. Neuropharmacology. 2004 Jan; 46(1):52-62. doi: 10.1016/j.neuropharm.2003.08.007. [PMID: 14654097]
  • Norman L M Wong, Joseph K C Tsui. Angiotensin II upregulates the expression of vasopressin V2 mRNA in the inner medullary collecting duct of the rat. Metabolism: clinical and experimental. 2003 Mar; 52(3):290-5. doi: 10.1053/meta.2003.50047. [PMID: 12647265]
  • Markus Manderscheid, Carmen Pereda-Fernández, Josef Pfeilschifter. Cyclic AMP increases rat inhibitor of apoptosis protein (RIAP1) mRNA in renal mesangial cells. Kidney international. 2002 Mar; 61(3):797-803. doi: 10.1046/j.1523-1755.2002.00223.x. [PMID: 11849428]
  • Sheng Nan Wu, Yuk Kang Lo, Chien Chich Chen, Hui Fang Li, Hung Ting Chiang. Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells. Biochemical pharmacology. 2002 Jan; 63(2):199-206. doi: 10.1016/s0006-2952(01)00873-5. [PMID: 11841794]
  • S I Yamagishi , D Edelstein, X L Du, Y Kaneda, M Guzmán, M Brownlee. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. The Journal of biological chemistry. 2001 Jul; 276(27):25096-100. doi: 10.1074/jbc.m007383200. [PMID: 11342529]
  • A Charbonneau, M Leclerc, M G Brunette. Effect of angiotensin II on calcium reabsorption by the luminal membranes of the nephron. American journal of physiology. Endocrinology and metabolism. 2001 Jun; 280(6):E928-36. doi: 10.1152/ajpendo.2001.280.6.e928. [PMID: 11350774]
  • B Fournès, S Sadekova, C Turbide, S Létourneau, N Beauchemin. The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity. Oncogene. 2001 Jan; 20(2):219-30. doi: 10.1038/sj.onc.1204058. [PMID: 11313949]
  • H W Lambert, E R Weiss, J M Lauder. Activation of 5-HT receptors that stimulate the adenylyl cyclase pathway positively regulates IGF-I in cultured craniofacial mesenchymal cells. Developmental neuroscience. 2001; 23(1):70-7. doi: 10.1159/000048697. [PMID: 11173928]
  • M Suzuki, K Ishibashi, G Ooki, S Tsuruoka, M Imai. Electrophysiologic characteristics of the Ca-permeable channels, ECaC and CaT, in the kidney. Biochemical and biophysical research communications. 2000 Aug; 274(2):344-9. doi: 10.1006/bbrc.2000.3135. [PMID: 10913341]
  • Y Aoki, D H Aviles, P A Jose. Biphasic effects of dopamine on 86rubidium uptake in rat renal proximal tubules. Clinical and experimental hypertension (New York, N.Y. : 1993). 2000 Apr; 22(3):289-301. doi: 10.1081/ceh-100100078. [PMID: 10803734]
  • G Dawson. Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2000 Apr; 18(2-3):247-57. doi: 10.1016/s0736-5748(99)00093-3. [PMID: 10715579]
  • N L Wong, B P Wong, J K Tsui. Vasopressin regulates endothelin-B receptor in rat inner medullary collecting duct. American journal of physiology. Renal physiology. 2000 Mar; 278(3):F369-74. doi: 10.1152/ajprenal.2000.278.3.f369. [PMID: 10710540]
  • R K Dubey, D G Gillespie, Z Mi, M Rosselli, P J Keller, E K Jackson. Estradiol inhibits smooth muscle cell growth in part by activating the cAMP-adenosine pathway. Hypertension (Dallas, Tex. : 1979). 2000 Jan; 35(1 Pt 2):262-6. doi: 10.1161/01.hyp.35.1.262. [PMID: 10642308]
  • H Harayama, M Miyake, S Kato. Role of cyclic adenosine 3',5'-monophosphate and serum albumin in head-to-head agglutination of boar spermatozoa. Reproduction, fertility, and development. 2000; 12(5-6):307-18. doi: 10.1071/rd00030. [PMID: 11451022]
  • L J Dai, G Ritchie, B W Bapty, D Kerstan, G A Quamme. Insulin stimulates Mg2+ uptake in mouse distal convoluted tubule cells. The American journal of physiology. 1999 12; 277(6):F907-13. doi: 10.1152/ajprenal.1999.277.6.f907. [PMID: 10600938]
  • W M Weber, H Cuppens, J J Cassiman, W Clauss, W Van Driessche. Capacitance measurements reveal different pathways for the activation of CFTR. Pflugers Archiv : European journal of physiology. 1999 Sep; 438(4):561-9. doi: 10.1007/s004249900086. [PMID: 10519152]
  • T T Wang, X Chen, X H Wu, S L Zhang, J S Chan. Molecular mechanism(s) of action of isoproterenol on the expression of the angiotensinogen gene in opossum kidney proximal tubular cells. Kidney international. 1999 May; 55(5):1713-23. doi: 10.1046/j.1523-1755.1999.00406.x. [PMID: 10231433]
  • K Koshimura, J Tanaka, Y Murakami, Y Kato. Enhancement of neuronal survival by 6R-tetrahydrobiopterin. Neuroscience. 1999 Jan; 88(2):561-9. doi: 10.1016/s0306-4522(98)00199-7. [PMID: 10197775]
  • U Wollina, D Prochnau, A Hoffmann, U C Hipler, R Wetzker. Vasoactive intestinal peptide and epidermal growth factor: co-mitogens or inhibitors of keratinocyte proliferation in vitro?. International journal of molecular medicine. 1998 Dec; 2(6):725-30. doi: 10.3892/ijmm.2.6.725. [PMID: 9850743]
  • Z B Pristupa, F McConkey, F Liu, H Y Man, F J Lee, Y T Wang, H B Niznik. Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter. Synapse (New York, N.Y.). 1998 Sep; 30(1):79-87. doi: 10.1002/(sici)1098-2396(199809)30:1<79::aid-syn10>3.0.co;2-k. [PMID: 9704884]
  • E Grönroos, C K Thodeti, A Sjölander. Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. Cell calcium. 1998 Jul; 24(1):9-16. doi: 10.1016/s0143-4160(98)90084-7. [PMID: 9793684]
  • A V Chibalin, C H Pedemonte, A I Katz, E Féraille, P O Berggren, A M Bertorello. Phosphorylation of the catalyic alpha-subunit constitutes a triggering signal for Na+,K+-ATPase endocytosis. The Journal of biological chemistry. 1998 Apr; 273(15):8814-9. doi: 10.1074/jbc.273.15.8814. [PMID: 9535860]
  • T T Wang, X H Wu, S L Zhang, J S Chan. Effect of glucose on the expression of the angiotensinogen gene in opossum kidney cells. Kidney international. 1998 Feb; 53(2):312-9. doi: 10.1046/j.1523-1755.1998.00775.x. [PMID: 9461091]
  • O N Kovbasnjuk, U Szmulowicz, K R Spring. Regulation of the MDCK cell tight junction. The Journal of membrane biology. 1998 Jan; 161(1):93-104. doi: 10.1007/s002329900317. [PMID: 9430624]
  • P I Karl, A Divald, A M Diehl, S E Fisher. Altered cyclic AMP-dependent human chorionic gonadotropin production in cultured human placental trophoblasts exposed to ethanol. Biochemical pharmacology. 1998 Jan; 55(1):45-51. doi: 10.1016/s0006-2952(97)00404-8. [PMID: 9413929]
  • B Siegmund, A Eigler, G Hartmann, U Hacker, S Endres. Adrenaline enhances LPS-induced IL-10 synthesis: evidence for protein kinase A-mediated pathway. International journal of immunopharmacology. 1998 Jan; 20(1-3):57-69. doi: 10.1016/s0192-0561(98)00014-9. [PMID: 9717082]
  • J F Qian, T T Wang, X H Wu, J Wu, C Ge, S Lachance, S Carriere, J S Chan. Angiotensinogen gene expression is stimulated by the cAMP-responsive element binding protein in opossum kidney cells. Journal of the American Society of Nephrology : JASN. 1997 Jul; 8(7):1072-9. doi: 10.1681/asn.v871072. [PMID: 9219156]
  • H Kato, M Shichiri, F Marumo, Y Hirata. Adrenomedullin as an autocrine/paracrine apoptosis survival factor for rat endothelial cells. Endocrinology. 1997 Jun; 138(6):2615-20. doi: 10.1210/endo.138.6.5197. [PMID: 9165056]
  • M F Ethier, J G Dobson. Adenosine stimulation of DNA synthesis in human endothelial cells. The American journal of physiology. 1997 Mar; 272(3 Pt 2):H1470-9. doi: 10.1152/ajpheart.1997.272.3.h1470. [PMID: 9087626]
  • R R Bowers, A Biboso, O Chavez. The role of alpha-MSH, its agonists, and C-AMP in in vitro avian melanocytes. Pigment cell research. 1997 Feb; 10(1-2):41-5. doi: 10.1111/j.1600-0749.1997.tb00464.x. [PMID: 9170161]
  • Y Aoki, F E Albrecht, K R Bergman, P A Jose. Stimulation of Na(+)-K(+)-2Cl- cotransport in rat medullary thick ascending limb by dopamine. The American journal of physiology. 1996 Dec; 271(6 Pt 2):R1561-7. doi: 10.1152/ajpregu.1996.271.6.r1561. [PMID: 8997353]
  • H Suzuki, I Nakamura, N Takahashi, T Ikuhara, K Matsuzaki, Y Isogai, M Hori, T Suda. Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts. Endocrinology. 1996 Nov; 137(11):4685-90. doi: 10.1210/endo.137.11.8895334. [PMID: 8895334]
  • A T Grazul-Bilska, L P Reynolds, J D Kirsch, D A Redmer. Gap junctional intercellular communication of bovine luteal cells from several stages of the estrous cycle: effects of cyclic adenosine 3',5'-monophosphate. Biology of reproduction. 1996 Mar; 54(3):538-45. doi: 10.1095/biolreprod54.3.538. [PMID: 8835374]
  • O Kovbasnjuk, J Y Chatton, W S Friauf, K R Spring. Determination of the Na permeability of the tight junctions of MDCK cells by fluorescence microscopy. The Journal of membrane biology. 1995 Dec; 148(3):223-32. doi: 10.1007/bf00235040. [PMID: 8747554]
  • J Gromada, P Rorsman, S Dissing, B S Wulff. Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release. FEBS letters. 1995 Oct; 373(2):182-6. doi: 10.1016/0014-5793(95)01070-u. [PMID: 7589461]
  • M Brignoni, O P Pignataro, M L Rodriguez, A Alvarez, D E Vega-Salas, E Rodriguez-Boulan, P J Salas. Cyclic AMP modulates the rate of 'constitutive' exocytosis of apical membrane proteins in Madin-Darby canine kidney cells. Journal of cell science. 1995 May; 108 ( Pt 5)(?):1931-43. doi: 10.1242/jcs.108.5.1931. [PMID: 7657716]
  • M Ming, T T Wang, S Lachance, A Delalandre, S Carrière, J S Chan. Expression of the angiotensinogen gene is synergistically stimulated by 8-BrcAMP and Dex in opossum kidney cells. The American journal of physiology. 1995 Jan; 268(1 Pt 2):R105-11. doi: 10.1152/ajpregu.1995.268.1.r105. [PMID: 7840309]
  • J deBlaquiere, F Walker, V P Michelangeli, L Fabri, A W Burgess. Platelet-derived growth factor stimulates the release of protein kinase A from the cell membrane. The Journal of biological chemistry. 1994 Feb; 269(7):4812-8. doi: 10.1016/s0021-9258(17)37616-0. [PMID: 8106451]
  • Z F Gu, T K Pradhan, D H Coy, R T Jensen. Galanin-induced relaxation in gastric smooth muscle cells is mediated by cyclic AMP. Peptides. 1994; 15(8):1425-30. doi: 10.1016/0196-9781(94)90119-8. [PMID: 7535425]
  • J W Kleineke, P A Janssens. Hormone-induced rise in cytosolic Ca2+ in axolotl hepatocytes: extracellular origin and control by cAMP. The American journal of physiology. 1993 Nov; 265(5 Pt 1):C1281-8. doi: 10.1152/ajpcell.1993.265.5.c1281. [PMID: 8238480]
  • J F Laycock, J I Hubbard, J H Schwartz, B A Stanton, H Valtin. The cAMP agonist Sp-cAMPS stimulates osmotic water transport across rat inner medullary collecting duct cells. Annals of the New York Academy of Sciences. 1993 Jul; 689(?):606-8. doi: 10.1111/j.1749-6632.1993.tb55605.x. [PMID: 8396881]
  • N Begum, W Leitner, J E Reusch, K E Sussman, B Draznin. GLUT-4 phosphorylation and its intrinsic activity. Mechanism of Ca(2+)-induced inhibition of insulin-stimulated glucose transport. The Journal of biological chemistry. 1993 Feb; 268(5):3352-6. doi: NULL. [PMID: 8381427]
  • Z F Gu, R T Jensen, P N Maton. A primary role for protein kinase A in smooth muscle relaxation induced by adrenergic agonists and neuropeptides. The American journal of physiology. 1992 Sep; 263(3 Pt 1):G360-4. doi: 10.1152/ajpgi.1992.263.3.g360. [PMID: 1329527]
  • J L Garvin, K R Spring. Regulation of apical membrane ion transport in Necturus gallbladder. The American journal of physiology. 1992 Jul; 263(1 Pt 1):C187-93. doi: 10.1152/ajpcell.1992.263.1.c187. [PMID: 1322040]
  • R J Anderson, R Breckon. cAMP stimulates protein kinase C activity in cultured renal LLC-PK1 cells. The American journal of physiology. 1991 Dec; 261(6 Pt 2):F945-50. doi: 10.1152/ajprenal.1991.261.6.f945. [PMID: 1661084]
  • R J Aerts, R J De Wit, M M Van Lookeren Campagne. Cyclic AMP induces a transient alkalinization in Dictyostelium. FEBS letters. 1987 Aug; 220(2):366-70. doi: 10.1016/0014-5793(87)80848-7. [PMID: 3038622]
  • T Braumann, B Jastorff, C Richter-Landsberg. Fate of cyclic nucleotides in PC12 cell cultures: uptake, metabolism, and effects of metabolites on nerve growth factor-induced neurite outgrowth. Journal of neurochemistry. 1986 Sep; 47(3):912-9. doi: 10.1111/j.1471-4159.1986.tb00697.x. [PMID: 3016191]
  • S J Scheinman, W J Stec, R Coulson. Effects of (Sp)- and (Rp)-adenosine cyclic 3',5'-phosphorothioates on electrolyte excretion by the isolated perfused rat kidney. Mineral and electrolyte metabolism. 1985; 11(2):85-90. doi: NULL. [PMID: 2985944]
  • R Coulson, J Baraniak, W J Stec, B Jastorff. Transport and metabolism of N6- and C8-substituted analogs of adenosine 3',5'-cyclic monophosphate and adenosine 3'5'-cyclic phosphorothioate by the isolated perfused rat kidney. Life sciences. 1983 Mar; 32(13):1489-98. doi: 10.1016/0024-3205(83)90915-3. [PMID: 6300581]