Linerixibat (BioDeep_00000837892)
代谢物信息卡片
化学式: C28H38N2O7S (546.2399598)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCC1(CS(=O)(=O)C2=C(C=C(C(=C2)CNC(CC(=O)O)CC(=O)O)OC)C(N1)C3=CC=CC=C3)CC
InChI: InChI=1S/C28H38N2O7S/c1-4-6-12-28(5-2)18-38(35,36)24-13-20(17-29-21(14-25(31)32)15-26(33)34)23(37-3)16-22(24)27(30-28)19-10-8-7-9-11-19/h7-11,13,16,21,27,29-30H,4-6,12,14-15,17-18H2,1-3H3,(H,31,32)(H,33,34)/t27-,28-/m1/s1
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C177170 - Ileal Bile Acid Transport Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D11539
- PubChem: 53492727
- DrugBank: DB11729
- ChEMBL: CHEMBL2387408
- CAS: 1345982-69-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maciej J Zamek-Gliszczynski, David Kenworthy, David A Bershas, Mitesh Sanghvi, Adrian I Pereira, Jennypher Mudunuru, Lee Crossman, Jill L Pirhalla, Karl M Thorpe, Jeremy M T J Dennison, Megan M McLaughlin, Matthew Allinder, Brandon Swift, Robin L O'Connor-Semmes, Graeme C Young. Pharmacokinetics and ADME Characterization of Intravenous and Oral [14C]-Linerixibat in Healthy Male Volunteers.
Drug metabolism and disposition: the biological fate of chemicals.
2021 12; 49(12):1109-1117. doi:
10.1124/dmd.121.000595. [PMID: 34625435] - David J Matye, Yuan Li, Cheng Chen, Xiaojuan Chao, Huaiwen Wang, Hongmin Ni, Wen-Xing Ding, Tiangang Li. Gut-restricted apical sodium-dependent bile acid transporter inhibitor attenuates alcohol-induced liver steatosis and injury in mice.
Alcoholism, clinical and experimental research.
2021 06; 45(6):1188-1199. doi:
10.1111/acer.14619. [PMID: 33885179] - David J Matye, Huaiwen Wang, Wenyi Luo, Rachel R Sharp, Cheng Chen, Lijie Gu, Kenneth L Jones, Wen-Xing Ding, Jacob E Friedman, Tiangang Li. Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis.
Cellular and molecular gastroenterology and hepatology.
2021; 12(3):1001-1019. doi:
10.1016/j.jcmgh.2021.04.013. [PMID: 33965587] - Vinod S Hegade, Alexandros Pechlivanis, Julie A K McDonald, Douglas Rees, Margaret Corrigan, Gideon M Hirschfield, Simon D Taylor-Robinson, Elaine Holmes, Julian R Marchesi, Stuart Kendrick, David E Jones. Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus.
Liver international : official journal of the International Association for the Study of the Liver.
2019 05; 39(5):967-975. doi:
10.1111/liv.14069. [PMID: 30735608] - Hiroko Ino, Akira Endo, Akira Wakamatsu, Hirofumi Ogura, Yotaro Numachi, Stuart Kendrick. Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Evaluations Following Single Oral Doses of GSK2330672 in Healthy Japanese Volunteers.
Clinical pharmacology in drug development.
2019 01; 8(1):70-77. doi:
10.1002/cpdd.576. [PMID: 29870578] - Vinod S Hegade, Stuart F W Kendrick, Robert L Dobbins, Sam R Miller, Douglas Thompson, Duncan Richards, James Storey, George E Dukes, Margaret Corrigan, Ronald P J Oude Elferink, Ulrich Beuers, Gideon M Hirschfield, David E Jones. Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study.
Lancet (London, England).
2017 03; 389(10074):1114-1123. doi:
10.1016/s0140-6736(17)30319-7. [PMID: 28187915] - Vinod S Hegade, Stuart F W Kendrick, Robert L Dobbins, Sam R Miller, Duncan Richards, James Storey, George Dukes, Kim Gilchrist, Susan Vallow, Graeme J Alexander, Margaret Corrigan, Gideon M Hirschfield, David E J Jones. BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial.
BMC gastroenterology.
2016 Jul; 16(1):71. doi:
10.1186/s12876-016-0481-9. [PMID: 27431238] - D J Nunez, X Yao, J Lin, A Walker, P Zuo, L Webster, S Krug-Gourley, M J Zamek-Gliszczynski, D S Gillmor, S L Johnson. Glucose and lipid effects of the ileal apical sodium-dependent bile acid transporter inhibitor GSK2330672: double-blind randomized trials with type 2 diabetes subjects taking metformin.
Diabetes, obesity & metabolism.
2016 07; 18(7):654-62. doi:
10.1111/dom.12656. [PMID: 26939572] - Yulin Wu, Christopher J Aquino, David J Cowan, Don L Anderson, Jeff L Ambroso, Michael J Bishop, Eric E Boros, Lihong Chen, Alan Cunningham, Robert L Dobbins, Paul L Feldman, Lindsey T Harston, Istvan W Kaldor, Ryan Klein, Xi Liang, Maggie S McIntyre, Christine L Merrill, Kristin M Patterson, Judith S Prescott, John S Ray, Shane G Roller, Xiaozhou Yao, Andrew Young, Josephine Yuen, Jon L Collins. Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes.
Journal of medicinal chemistry.
2013 Jun; 56(12):5094-114. doi:
10.1021/jm400459m. [PMID: 23678871]