Rapacuronium (BioDeep_00000837860)
代谢物信息卡片
化学式: C37H61N2O4+ (597.4631085999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)OC(=O)C)N5CCCCC5)C)C)[N+]6(CCCCC6)CC=C
InChI: InChI=1S/C37H61N2O4/c1-6-20-39(21-12-9-13-22-39)32-24-30-28-15-14-27-23-33(42-26(3)40)31(38-18-10-8-11-19-38)25-37(27,5)29(28)16-17-36(30,4)35(32)43-34(41)7-2/h6,27-33,35H,1,7-25H2,2-5H3/q+1/t27-,28+,29-,30-,31-,32-,33-,35-,36-,37-/m0/s1
描述信息
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:135845
- PubChem: 5311399
- DrugBank: DB04834
- ChEMBL: CHEMBL1201352
- CAS: 465499-11-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hans D de Boer, Jan van Egmond, Jacques J Driessen, Leo H D Booij. Update on the management of neuromuscular block: focus on sugammadex.
Neuropsychiatric disease and treatment.
2007; 3(5):539-44. doi:
NULL. [PMID: 19300584] - Robert E Black, Ralph Gertler, Peter M C Wright, Mario T Cancemi, H A Tillmann Hein, Michael A E Ramsay. Pharmacokinetic analysis of rapacuronium and its metabolite during liver transplantation: an assessment of its potential as a pharmacodynamic probe.
Proceedings (Baylor University. Medical Center).
2003 Jul; 16(3):275-9. doi:
10.1080/08998280.2003.11927913. [PMID: 16278697] - William J Wight, Peter M C Wright. Pharmacokinetics and pharmacodynamics of rapacuronium bromide.
Clinical pharmacokinetics.
2002; 41(13):1059-76. doi:
10.2165/00003088-200241130-00004. [PMID: 12403643] - E W Moore, J M Hunter. The new neuromuscular blocking agents: do they offer any advantages?.
British journal of anaesthesia.
2001 Dec; 87(6):912-25. doi:
10.1093/bja/87.6.912. [PMID: 11878696] - H J Sparr, T M Beaufort, T Fuchs-Buder. Newer neuromuscular blocking agents: how do they compare with established agents?.
Drugs.
2001; 61(7):919-42. doi:
10.2165/00003495-200161070-00003. [PMID: 11434449] - D M Fisher, G A Dempsey, D P Atherton, R Brown, A Abengochea, J M Hunter. Effect of renal failure and cirrhosis on the pharmacokinetics and neuromuscular effects of rapacuronium administered by bolus followed by infusion.
Anesthesiology.
2000 Dec; 93(6):1384-91. doi:
10.1097/00000542-200012000-00007. [PMID: 11149430] - L M Reynolds, A Infosino, R Brown, J Hsu, D M Fisher. Pharmacokinetics of rapacuronium in infants and children with intravenous and intramuscular administration.
Anesthesiology.
2000 Feb; 92(2):376-86. doi:
10.1097/00000542-200002000-00018. [PMID: 10691223] - P Duvaldestin, V Slavov, Y Rebufat. Pharmacokinetics and pharmacodynamics of rapacuronium in patients with cirrhosis.
Anesthesiology.
1999 Nov; 91(5):1305-10. doi:
10.1097/00000542-199911000-00022. [PMID: 10551581] - J H Levy, M Pitts, A Thanopoulos, F Szlam, R Bastian, J Kim. The effects of rapacuronium on histamine release and hemodynamics in adult patients undergoing general anesthesia.
Anesthesia and analgesia.
1999 Aug; 89(2):290-5. doi:
10.1097/00000539-199908000-00005. [PMID: 10439732] - K Sato, K Windisch, I Matko, E S Vizi. Effects of non-depolarizing neuromuscular blocking agents on norepinephrine release from human atrial tissue obtained during cardiac surgery.
British journal of anaesthesia.
1999 Jun; 82(6):904-9. doi:
10.1093/bja/82.6.904. [PMID: 10562787] - D M Fisher, R Kahwaji, D Bevan, G Bikhazi, R J Fragen, M S Angst, E Ornstein, R S Matteo. Factors affecting the pharmacokinetic characteristics of rapacuronium.
Anesthesiology.
1999 Apr; 90(4):993-1000. doi:
10.1097/00000542-199904000-00011. [PMID: 10201669] - D P Atherton, J M Hunter. Clinical pharmacokinetics of the newer neuromuscular blocking drugs.
Clinical pharmacokinetics.
1999 Mar; 36(3):169-89. doi:
10.2165/00003088-199936030-00001. [PMID: 10223167] - S Schiere, J H Proost, M Schuringa, J M Wierda. Pharmacokinetics and pharmacokinetic-dynamic relationship between rapacuronium (Org 9487) and its 3-desacetyl metabolite (Org 9488).
Anesthesia and analgesia.
1999 Mar; 88(3):640-7. doi:
10.1097/00000539-199903000-00032. [PMID: 10072020] - P M Wright, R Brown, M Lau, D M Fisher. A pharmacodynamic explanation for the rapid onset/offset of rapacuronium bromide.
Anesthesiology.
1999 Jan; 90(1):16-23. doi:
10.1097/00000542-199901000-00005. [PMID: 9915308] - J Szenohradszky, J E Caldwell, P M Wright, R Brown, M Lau, A M Luks, D M Fisher. Influence of renal failure on the pharmacokinetics and neuromuscular effects of a single dose of rapacuronium bromide.
Anesthesiology.
1999 Jan; 90(1):24-35. doi:
10.1097/00000542-199901000-00006. [PMID: 9915309] - L van den Broek, J M Wierda, N J Smeulers, J H Proost. Pharmacodynamics and pharmacokinetics of an infusion of Org 9487, a new short-acting steroidal neuromuscular blocking agent.
British journal of anaesthesia.
1994 Sep; 73(3):331-5. doi:
10.1093/bja/73.3.331. [PMID: 7946859] - J M Wierda, A M Beaufort, U W Kleef, N J Smeulers, S Agoston. Preliminary investigations of the clinical pharmacology of three short-acting non-depolarizing neuromuscular blocking agents, Org 9453, Org 9489 and Org 9487.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1994 Mar; 41(3):213-20. doi:
10.1007/bf03009833. [PMID: 7910526]