N-Geranyl-N-(2-adamantyl)ethane-1,2-diamine (BioDeep_00000837859)
代谢物信息卡片
化学式: C22H38N2 (330.3034828)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCCC(=CCNCCNC1C2CC3CC(C2)CC1C3)C)C
InChI: InChI=1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+
描述信息
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gautam Kumar, Shobhna Kapoor. Targeting mycobacterial membranes and membrane proteins: Progress and limitations.
Bioorganic & medicinal chemistry.
2023 03; 81(?):117212. doi:
10.1016/j.bmc.2023.117212. [PMID: 36804747] - Weihua Qiu, Youzhong Guo. Analysis of the oligomeric state of mycobacterial membrane protein large 3 and its interaction with SQ109 with native cell membrane nanoparticles system.
Biochimica et biophysica acta. Biomembranes.
2022 02; 1864(1):183793. doi:
10.1016/j.bbamem.2021.183793. [PMID: 34655545] - Sergey Bukhdruker, Tatsiana Varaksa, Irina Grabovec, Egor Marin, Polina Shabunya, Maria Kadukova, Sergei Grudinin, Anton Kavaleuski, Anastasiia Gusach, Andrei Gilep, Valentin Borshchevskiy, Natallia Strushkevich. Hydroxylation of Antitubercular Drug Candidate, SQ109, by Mycobacterial Cytochrome P450.
International journal of molecular sciences.
2020 Oct; 21(20):. doi:
10.3390/ijms21207683. [PMID: 33081390] - Xavier A Kayigire, Sven O Friedrich, Lize van der Merwe, Peter R Donald, Andreas H Diacon. Simultaneous staining of sputum smears for acid-fast and lipid-containing Myobacterium tuberculosis can enhance the clinical evaluation of antituberculosis treatments.
Tuberculosis (Edinburgh, Scotland).
2015 Dec; 95(6):770-779. doi:
10.1016/j.tube.2015.08.001. [PMID: 26318558] - Norbert Heinrich, Rodney Dawson, Jeannine du Bois, Kim Narunsky, Gary Horwith, Andrew J Phipps, Carol A Nacy, Rob E Aarnoutse, Martin J Boeree, Stephen H Gillespie, Amour Venter, Sonja Henne, Andrea Rachow, Patrick P J Phillips, Michael Hoelscher, Andreas H Diacon. Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients.
The Journal of antimicrobial chemotherapy.
2015 May; 70(5):1558-66. doi:
10.1093/jac/dku553. [PMID: 25630641] - Kapil Tahlan, Regina Wilson, David B Kastrinsky, Kriti Arora, Vinod Nair, Elizabeth Fischer, S Whitney Barnes, John R Walker, David Alland, Clifton E Barry, Helena I Boshoff. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy.
2012 Apr; 56(4):1797-809. doi:
10.1128/aac.05708-11. [PMID: 22252828] - Georgi M Dobrikov, Violeta Valcheva, Margarita Stoilova-Disheva, Georgi Momekov, Pavleta Tzvetkova, Angel Chimov, Vladimir Dimitrov. Synthesis and in vitro antimycobacterial activity of compounds derived from (R)- and (S)-2-amino-1-butanol - The crucial role of the configuration.
European journal of medicinal chemistry.
2012 Feb; 48(?):45-56. doi:
10.1016/j.ejmech.2011.11.035. [PMID: 22154833] - Joe Liu, Daniel Obando, Vivian Liao, Tulip Lifa, Rachel Codd. The many faces of the adamantyl group in drug design.
European journal of medicinal chemistry.
2011 Jun; 46(6):1949-63. doi:
10.1016/j.ejmech.2011.01.047. [PMID: 21354674] - Oluseye K Onajole, Karnishree Govender, Patrick Govender, Paul D van Helden, Hendrik G Kruger, Glenn E M Maguire, Karen Muthusamy, Manormoney Pillay, Ian Wiid, Thavendran Govender. Pentacyclo-undecane derived cyclic tetra-amines: synthesis and evaluation as potent anti-tuberculosis agents.
European journal of medicinal chemistry.
2009 Nov; 44(11):4297-305. doi:
10.1016/j.ejmech.2009.07.015. [PMID: 19679378] - Lee Jia, Patricia E Noker, Lori Coward, Gregory S Gorman, Marina Protopopova, Joseph E Tomaszewski. Interspecies pharmacokinetics and in vitro metabolism of SQ109.
British journal of pharmacology.
2006 Mar; 147(5):476-85. doi:
10.1038/sj.bjp.0706650. [PMID: 16432511]