Firibastat (BioDeep_00000837852)

   


代谢物信息卡片


Firibastat

化学式: C8H20N2O6S4 (368.020418)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CS(=O)(=O)O)C(CSSCC(CCS(=O)(=O)O)N)N
InChI: InChI=1S/C8H20N2O6S4/c9-7(1-3-19(11,12)13)5-17-18-6-8(10)2-4-20(14,15)16/h7-8H,1-6,9-10H2,(H,11,12,13)(H,14,15,16)/t7-,8-/m0/s1

描述信息

D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor

同义名列表

1 个代谢物同义名

Firibastat



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yannick Marc, Reda Hmazzou, Nadia De Mota, Fabrice Balavoine, Catherine Llorens-Cortes. Effects of firibastat in combination with enalapril and hydrochlorothiazide on blood pressure and vasopressin release in hypertensive DOCA-salt rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Aug; 140(?):111682. doi: 10.1016/j.biopha.2021.111682. [PMID: 34020248]
  • Michel Azizi, Pierre-Yves Courand, Thierry Denolle, Pascal Delsart, Valentina Zhygalina, Laurence Amar, Pierre Lantelme, Claire Mounier-Vehier, Nadia De Mota, Fabrice Balavoine, Catherine Llorens-Cortes. A pilot double-blind randomized placebo-controlled crossover pharmacodynamic study of the centrally active aminopeptidase A inhibitor, firibastat, in hypertension. Journal of hypertension. 2019 08; 37(8):1722-1728. doi: 10.1097/hjh.0000000000002092. [PMID: 30882604]
  • Mathilde Keck, Hugo De Almeida, Delphine Compère, Nicolas Inguimbert, Adrien Flahault, Fabrice Balavoine, Bernard Roques, Catherine Llorens-Cortes. NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension. Hypertension (Dallas, Tex. : 1979). 2019 06; 73(6):1300-1307. doi: 10.1161/hypertensionaha.118.12499. [PMID: 31067198]
  • Frans H H Leenen, Monir Ahmad, Yannick Marc, Catherine Llorens-Cortes. Specific Inhibition of Brain Angiotensin III Formation as a New Strategy for Prevention of Heart Failure After Myocardial Infarction. Journal of cardiovascular pharmacology. 2019 02; 73(2):82-91. doi: 10.1097/fjc.0000000000000638. [PMID: 30531435]
  • Yannick Marc, Reda Hmazzou, Fabrice Balavoine, Adrien Flahault, Catherine Llorens-Cortes. Central antihypertensive effects of chronic treatment with RB150: an orally active aminopeptidase A inhibitor in deoxycorticosterone acetate-salt rats. Journal of hypertension. 2018 03; 36(3):641-650. doi: 10.1097/hjh.0000000000001563. [PMID: 28968260]
  • Fabrice Balavoine, Michel Azizi, Damien Bergerot, Nadia De Mota, Rémi Patouret, Bernard P Roques, Catherine Llorens-Cortes. Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug. Clinical pharmacokinetics. 2014 Apr; 53(4):385-95. doi: 10.1007/s40262-013-0125-y. [PMID: 24337978]
  • Laurence Bodineau, Alain Frugière, Yannick Marc, Nicolas Inguimbert, Céline Fassot, Fabrice Balavoine, Bernard Roques, Catherine Llorens-Cortes. Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension. Hypertension (Dallas, Tex. : 1979). 2008 May; 51(5):1318-25. doi: 10.1161/hypertensionaha.107.098772. [PMID: 18362226]