Selitrectinib (BioDeep_00000837832)
代谢物信息卡片
化学式: C20H21FN6O (380.1761)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2=C(C=C(C=N2)F)C3CCCN3C4=NC5=C(C=NN5C=C4)C(=O)N1
InChI: InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C155765 - TRK Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
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相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yang Zhou, Shuang Xiang, Fang Yang, Xiaoyun Lu. Targeting Gatekeeper Mutations for Kinase Drug Discovery.
Journal of medicinal chemistry.
2022 12; 65(23):15540-15558. doi:
10.1021/acs.jmedchem.2c01361. [PMID: 36395392] - Zuqin Wang, Jie Wang, Yongjin Wang, Shuang Xiang, Xiaojuan Song, Zhengchao Tu, Yang Zhou, Zhi-Min Zhang, Zhang Zhang, Ke Ding, Xiaoyun Lu. Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance.
Journal of medicinal chemistry.
2022 04; 65(8):6325-6337. doi:
10.1021/acs.jmedchem.2c00308. [PMID: 35426680] - Wenlong Li, Rolf W Sparidans, Margarida L F Martins, Mujtaba El-Lari, Maria C Lebre, Olaf van Tellingen, Jos H Beijnen, Alfred H Schinkel. ABCB1 and ABCG2 Restrict Brain and Testis Accumulation and, Alongside CYP3A, Limit Oral Availability of the Novel TRK Inhibitor Selitrectinib.
Molecular cancer therapeutics.
2021 06; 20(6):1173-1182. doi:
10.1158/1535-7163.mct-20-0705. [PMID: 33785654] - Rolf W Sparidans, Wenlong Li, Alfred H Schinkel, Jos H Beijnen. Bioanalytical assay for the novel TRK inhibitor selitrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Aug; 1122-1123(?):78-82. doi:
10.1016/j.jchromb.2019.05.026. [PMID: 31163324] - Emiliano Cocco, Maurizio Scaltriti, Alexander Drilon. NTRK fusion-positive cancers and TRK inhibitor therapy.
Nature reviews. Clinical oncology.
2018 12; 15(12):731-747. doi:
10.1038/s41571-018-0113-0. [PMID: 30333516] - E J Zambraski, C M Tipton, T K Tcheng, H R Jordon, A C Vailas, A K Callahan. Iowa wrestling study: changes in the urinary profiles of wrestlers prior to and after competition.
Medicine and science in sports.
1975; 7(3):217-20. doi:
NULL. [PMID: 1625]
