Manitimus (BioDeep_00000837822)
代谢物信息卡片
Manitimus
化学式: C15H11F3N2O2 (308.07725819999996)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C#CCCC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O
InChI: InChI=1S/C15H11F3N2O2/c1-2-3-4-13(21)12(9-19)14(22)20-11-7-5-10(6-8-11)15(16,17)18/h1,5-8,21H,3-4H2,(H,20,22)/b13-12-
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 54686843
- DrugBank: DB06481
- ChEMBL: CHEMBL4754445
- CAS: 185915-33-7
- CAS: 202057-76-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zbigniew Wlodarczyk, Yves Vanrenterghem, Bernhard K Krämer, Jean-Paul Squifflet, Marek Ostrowski. A multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation.
BMC nephrology.
2012 Jul; 13(?):68. doi:
10.1186/1471-2369-13-68. [PMID: 22835011] - Antonio Guasch, Prabir Roy-Chaudhury, E Steve Woodle, William Fitzsimmons, John Holman, M Roy First. Assessment of efficacy and safety of FK778 in comparison with standard care in renal transplant recipients with untreated BK nephropathy.
Transplantation.
2010 Oct; 90(8):891-7. doi:
10.1097/tp.0b013e3181f2c94b. [PMID: 20811320] - S Bloudícková, J Rajnoch, A Lodererová, E Honsová, O Viklický. Leflunomide derivate FK 778 in accelerated renal injury in transgenic rat.
Folia biologica.
2010; 56(2):72-7. doi:
. [PMID: 20492759] - Jukka M Rintala, Johanna Savikko, Sini E Rintala, Eva von Willebrand. FK778 ameliorates post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2008 Nov; 23(11):3446-55. doi:
10.1093/ndt/gfn340. [PMID: 18558624] - Jens Lutz, Hai Huang, Meihong Deng, Bettina Wagner, Marcel Roos, Christoph Schmaderer, Matthias Strobl, Uwe Heemann. The effect of FK778 on the progression of chronic allograft nephropathy in a rat model.
Transplantation.
2007 Mar; 83(6):741-6. doi:
10.1097/01.tp.0000255558.02582.ce. [PMID: 17414707] - J M Rintala, J Savikko, S E Rintala, E von Willebrand. The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression.
Transplantation proceedings.
2006 Dec; 38(10):3239-40. doi:
10.1016/j.transproceed.2006.10.051. [PMID: 17175234] - J M Rintala, J Savikko, S E Rintala, E von Willebrand. The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta.
Transplantation proceedings.
2006 Oct; 38(8):2719-21. doi:
10.1016/j.transproceed.2006.08.079. [PMID: 17098049] - M Alessiani, F Abbiati, S Zonta, E Zitelli, M Bardone, L Cobianchi, J Viganò, M Doni, M Mazzilli, T Dominioni, D Kabiri, A Bottazzi, P Morbini, M D Molinaro, P Dionigi. FK778 and tacrolimus combination therapy to control acute rejection after pig intestinal transplantation.
Transplantation proceedings.
2006 Jul; 38(6):1809-11. doi:
10.1016/j.transproceed.2006.05.042. [PMID: 16908288] - M Molinaro, C Carazzone, D Barbano, F Abbiati, M Alessiani, M Regazzi. Assessment of an LC-MS method for plasma quantification of the new immunosuppressant FK778 through comparison with HPLC-UV.
Transplantation proceedings.
2005 Jul; 37(6):2722-7. doi:
10.1016/j.transproceed.2005.06.069. [PMID: 16182794] - David L Evers, Xin Wang, Shu-Mei Huong, Kenneth A Andreoni, Eng-Shang Huang. Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778.
Antiviral research.
2005 Jan; 65(1):1-12. doi:
10.1016/j.antiviral.2004.03.007. [PMID: 15652966] - Yu-Luan Chen, Shahzad Akhtar, Hidetsugu Murai, Masakazu Kobayashi. In vivo metabolism for the hydroxylation of FK778 to the metabolite M3 in humans studied by enantioselective liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2005; 19(18):2681-8. doi:
10.1002/rcm.2115. [PMID: 16124029] - S Yamamoto, T Okuda, K Yamasaki, H Tanaka, S Takemura, Y Minamiyama, K Ikeda, K Hirohashi, S Suehiro. FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506.
Transplantation proceedings.
2005 Jan; 37(1):126-9. doi:
10.1016/j.transproceed.2005.02.016. [PMID: 15808570] - Tobias Deuse, Sonja Schrepfer, Hansjörg Schäfer, Friedrich Koch-Nolte, Edzard Schwedhelm, Rainer H Böger, Hermann Reichenspurner. FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.
Transplantation.
2004 Jul; 78(1):71-7. doi:
10.1097/01.tp.0000128629.53843.14. [PMID: 15257041] - Yves Vanrenterghem, Johannes P van Hooff, Marian Klinger, Zbigniew Wlodarczyk, Jean-Paul Squifflet, Georges Mourad, Peter Neuhaus, Adam Jurewicz, Lionel Rostaing, Bernard Charpentier, Leszek Paczek, Henri Kreis, Rene Chang, Leendert C Paul, Josep M Grinyó, Colin Short. The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients.
Transplantation.
2004 Jul; 78(1):9-14. doi:
10.1097/01.tp.0000132562.54089.62. [PMID: 15257032] - Jonathan Fawcett, David W Johnson. FK778: a powerful immunosuppressive, but will it really be good for you?.
Transplantation.
2004 Jul; 78(1):7-8. doi:
10.1097/01.tp.0000132563.08111.88. [PMID: 15257031] - Michael Fischereder, Matthias Kretzler. New immunosuppressive strategies in renal transplant recipients.
Journal of nephrology.
2004 Jan; 17(1):9-18. doi:
NULL. [PMID: 15151254] - Kupa K Bilolo, Jun Ouyang, Xiang Wang, Shengyun Zhu, Wenlei Jiang, Shijie Qi, Dasheng Xu, Marie J Hebert, Ihor Bekersky, William E Fitzsimmons, Huifang Chen. Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat.
Transplantation.
2003 Jun; 75(11):1881-7. doi:
10.1097/01.tp.0000064710.78335.d3. [PMID: 12811249] - Minh Diem Vu, Shijie Qi, Xiang Wang, Wenlei Jiang, Anlun Ma, Dasheng Xu, Ihor Bekersky, William E Fitzsimmons, Jiangping Wu, Huifang Chen. Combination therapy of malononitrilamide FK778 with tacrolimus on cell proliferation assays and in rats receiving renal allografts.
Transplantation.
2003 May; 75(9):1455-9. doi:
10.1097/01.tp.0000058811.25785.f4. [PMID: 12792496] - Tudor Bîrsan, Camille Dambrin, Jochen Klupp, Mario Stalder, Michael J Larson, William E Fitzsimmons, Randall E Morris. In vivo pharmacokinetic and pharmacodynamic evaluation of the malononitrilamide FK778 in non-human primates.
Transplant international : official journal of the European Society for Organ Transplantation.
2003 May; 16(5):354-60. doi:
10.1007/s00147-003-0591-5. [PMID: 12712238] - Andrew E Kyles, Clare R Gregory, Stephen M Griffey, Lynda Bernsteen, Randall E Morris. Modified noble plication for the prevention of intestinal intussusception after renal transplantation in dogs.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2003 May; 16(3):161-6. doi:
10.1080/08941930390205791. [PMID: 12775432] - Fan Pan, Aaron Ebbs, Carmen Wynn, Laurie Erickson, Mei-Shiang Jang, Gladys Crews, Ogert Fisniku, Masakazu Kobayashi, Leendert C Paul, Hallgrimur Benediktsson, And Hongsi Jiang. FK778, a powerful new immunosuppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts.
Transplantation.
2003 Apr; 75(8):1110-4. doi:
10.1097/01.tp.0000063704.19149.e3. [PMID: 12717186] - Andrew E Kyles, Clare R Gregory, Stephen M Griffey, Lynda Bernsteen, Jon Pierce, Herman S Lilja, Randall E Morris. Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs.
Transplantation.
2003 Apr; 75(8):1128-33. doi:
10.1097/01.tp.0000061789.97072.12. [PMID: 12717190] - Shijie Qi, Shengyun Zhu, Dasheng Xu, Xiang Wang, Jun Ouyang, Wenlei Jiang, Minh Diem Vu, Kupa Bilolo, Anlun Ma, Stephane Johnson, Pierre Daloze, Ihor Bekersky, William E Fitzsimmons, Huifang Chen. Significant prolongation of renal allograft survival by delayed combination therapy of FK778 with tacrolimus in nonhuman primates.
Transplantation.
2003 Apr; 75(8):1124-8. doi:
10.1097/01.tp.0000061787.68121.4d. [PMID: 12717189] - Andrew E Kyles, Clare R Gregory, Stephen M Griffey, Joshua Jackson, Lynda Bernsteen, Randall E Morris. An evaluation of combined immunosuppression with MNA 715 and microemulsified cyclosporine on renal allograft rejection in mismatched mongrel dogs.
Veterinary surgery : VS.
2002 Jul; 31(4):358-66. doi:
10.1053/jvet.2002.33615. [PMID: 12094350] - Maeng Bong Jin, Masato Nakayama, Toshiro Ogata, Miri Fujita, Kazuhiro Mino, Masahiko Taniguchi, Tomomi Suzuki, Tsuyoshi Shimamura, Hiroyuki Furukawa, Satoru Todo. A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs.
Surgery.
2002 Jul; 132(1):72-9. doi:
10.1067/msy.2002.125390. [PMID: 12110798] - A E Kyles, C R Gregory, S M Griffey, L Bernsteen, J Jackson, R E Morris. Leflunomide analog, MNA-715, plus cyclosporine reduces renal allograft rejection in mismatched dogs.
Transplantation proceedings.
2001 Feb; 33(1-2):368-9. doi:
10.1016/s0041-1345(00)02051-0. [PMID: 11266865]