Daporinad (BioDeep_00000837813)
代谢物信息卡片
FK866 (APO866, Daporinad)
化学式: C24H29N3O2 (391.2259654)
中文名称: (E)-Daporinad
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3
InChI: InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
描述信息
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
C471 - Enzyme Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:187413
- ChEBI: CHEBI:94671
- PubChem: 6914657
- DrugBank: DB12731
- ChEMBL: CHEMBL566757
- CAS: 1198425-96-5
- CAS: 201034-75-5
- CAS: 658084-64-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Romana R Gerner, Sophie Macheiner, Simon Reider, Kerstin Siegmund, Felix Grabherr, Lisa Mayr, Bernhard Texler, Patrizia Moser, Maria Effenberger, Hubert Schwaighofer, Alexander R Moschen, Brigitte Kircher, Herbert Oberacher, Robert Zeiser, Herbert Tilg, David Nachbaur. Targeting NAD immunometabolism limits severe graft-versus-host disease and has potent antileukemic activity.
Leukemia.
2020 07; 34(7):1885-1897. doi:
10.1038/s41375-020-0709-0. [PMID: 31974433] - Fahad A Alhumaydhi, Debora de O Lopes, Diana L Bordin, Abdullah S M Aljohani, Cameron B Lloyd, Michael D McNicholas, Larissa Milano, Clara F Charlier, Izabel Villela, João Antonio P Henriques, Kathryn E Plant, Ruan M Elliott, Lisiane B Meira. Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition.
Scientific reports.
2020 02; 10(1):2209. doi:
10.1038/s41598-020-59072-6. [PMID: 32042007] - Weijie Xie, Ting Zhu, Ping Zhou, Huibo Xu, Xiangbao Meng, Tao Ding, Fengwei Nan, Guibo Sun, Xiaobo Sun. Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1α Signaling Pathways Mediated by the NAMPT-NAD Pathway.
Oxidative medicine and cellular longevity.
2020; 2020(?):7308386. doi:
10.1155/2020/7308386. [PMID: 33149812] - Sanli Xing, Yiran Hu, Xujiao Huang, Dingzhu Shen, Chuan Chen. Nicotinamide phosphoribosyltransferase‑related signaling pathway in early Alzheimer's disease mouse models.
Molecular medicine reports.
2019 Dec; 20(6):5163-5171. doi:
10.3892/mmr.2019.10782. [PMID: 31702813] - Misaki Nagaya, Hirokazu Hara, Tetsuro Kamiya, Tetsuo Adachi. Inhibition of NAMPT markedly enhances plasma-activated medium-induced cell death in human breast cancer MDA-MB-231 cells.
Archives of biochemistry and biophysics.
2019 11; 676(?):108155. doi:
10.1016/j.abb.2019.108155. [PMID: 31628926] - Cristina Travelli, Silvio Aprile, Daiana Mattoteia, Giorgia Colombo, Nausicaa Clemente, Eugenio Scanziani, Salvatore Terrazzino, Maria Alessandra Alisi, Lorenzo Polenzani, Giorgio Grosa, Armando A Genazzani, Gian Cesare Tron, Ubaldina Galli. Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group.
European journal of medicinal chemistry.
2019 Nov; 181(?):111576. doi:
10.1016/j.ejmech.2019.111576. [PMID: 31400709] - Mioara Larion, Tyrone Dowdy, Victor Ruiz-Rodado, Matthew W Meyer, Hua Song, Wei Zhang, Dionne Davis, Mark R Gilbert, Adrian Lita. Detection of Metabolic Changes Induced via Drug Treatments in Live Cancer Cells and Tissue Using Raman Imaging Microscopy.
Biosensors.
2018 Dec; 9(1):. doi:
10.3390/bios9010005. [PMID: 30597885] - Jeffrey P Chmielewski, Sarah C Bowlby, Frances B Wheeler, Lihong Shi, Guangchao Sui, Amanda L Davis, Timothy D Howard, Ralph B D'Agostino, Lance D Miller, S Joseph Sirintrapun, Scott D Cramer, Steven J Kridel. CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools.
Molecular cancer research : MCR.
2018 11; 16(11):1687-1700. doi:
10.1158/1541-7786.mcr-17-0526. [PMID: 30076241] - Nicolas Diguet, Samuel A J Trammell, Cynthia Tannous, Robin Deloux, Jérôme Piquereau, Nathalie Mougenot, Anne Gouge, Mélanie Gressette, Boris Manoury, Jocelyne Blanc, Marie Breton, Jean-François Decaux, Gareth G Lavery, István Baczkó, Joffrey Zoll, Anne Garnier, Zhenlin Li, Charles Brenner, Mathias Mericskay. Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.
Circulation.
2018 05; 137(21):2256-2273. doi:
10.1161/circulationaha.116.026099. [PMID: 29217642] - Melanie Penke, Susanne Schuster, Theresa Gorski, Rolf Gebhardt, Wieland Kiess, Antje Garten. Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells.
Lipids in health and disease.
2017 Oct; 16(1):191. doi:
10.1186/s12944-017-0583-6. [PMID: 28974242] - Ling-Fang Wang, Xiao-Nv Wang, Cong-Cong Huang, Long Hu, Yun-Fei Xiao, Xiao-Hui Guan, Yi-Song Qian, Ke-Yu Deng, Hong-Bo Xin. Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway.
Lipids in health and disease.
2017 Apr; 16(1):82. doi:
10.1186/s12944-017-0464-z. [PMID: 28449683] - Peixin Huang, Mark W Lee, Keivan Sadrerafi, Daniel P Heruth, Li Q Zhang, Dev Maulik, Shui Qing Ye. MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866.
Drug design, development and therapy.
2017; 11(?):629-641. doi:
10.2147/dddt.s125349. [PMID: 28424540] - S Riammer, A Garten, M Schaab, S Grunewald, W Kiess, J Kratzsch, U Paasch. Nicotinamide phosphoribosyltransferase production in human spermatozoa is influenced by maturation stage.
Andrology.
2016 11; 4(6):1045-1053. doi:
10.1111/andr.12252. [PMID: 27566659] - Takeshi Iwasa, Toshiya Matsuzaki, Sumika Matsui, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Eri Takiguchi, Takako Kawakita, Akira Kuwahara, Toshiyuki Yasui, Minoru Irahara. The sensitivity of adipose tissue visfatin mRNA expression to lipopolysaccharide-induced endotoxemia is increased by ovariectomy in female rats.
International immunopharmacology.
2016 Jun; 35(?):243-247. doi:
10.1016/j.intimp.2016.04.002. [PMID: 27083000] - Xiao-Dong Zou, Shao-Qing Guo, Zhi-Wei Hu, Wei-Lang Li. NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity.
Molecular medicine reports.
2016 May; 13(5):4058-64. doi:
10.3892/mmr.2016.5034. [PMID: 27035562] - Mélodie Diot, Maxime Reverchon, Christelle Ramé, Yannick Baumard, Joëlle Dupont. Expression and effect of NAMPT (visfatin) on progesterone secretion in hen granulosa cells.
Reproduction (Cambridge, England).
2015 Jul; 150(1):53-63. doi:
10.1530/rep-15-0021. [PMID: 25918435] - Qianyi Peng, Song Hui Jia, Jean Parodo, Yuhang Ai, John C Marshall. Pre-B cell colony enhancing factor induces Nampt-dependent translocation of the insulin receptor out of lipid microdomains in A549 lung epithelial cells.
American journal of physiology. Endocrinology and metabolism.
2015 Feb; 308(4):E324-33. doi:
10.1152/ajpendo.00006.2014. [PMID: 25516545] - Yan Zhao, Xin-Zhu Liu, Wei-Wei Tian, Yun-Feng Guan, Pei Wang, Chao-Yu Miao. Extracellular visfatin has nicotinamide phosphoribosyltransferase enzymatic activity and is neuroprotective against ischemic injury.
CNS neuroscience & therapeutics.
2014 Jun; 20(6):539-47. doi:
10.1111/cns.12273. [PMID: 24750959] - Kengo Nomura, Sawako Tatsumi, Atsumi Miyagawa, Yuji Shiozaki, Shohei Sasaki, Ichiro Kaneko, Mikiko Ito, Shinsuke Kido, Hiroko Segawa, Mitsue Sano, Tsutomu Fukuwatari, Katsumi Shibata, Ken-ichi Miyamoto. Hepatectomy-related hypophosphatemia: a novel phosphaturic factor in the liver-kidney axis.
Journal of the American Society of Nephrology : JASN.
2014 Apr; 25(4):761-72. doi:
10.1681/asn.2013060569. [PMID: 24262791] - Alberto Benito-Martin, Alvaro C Ucero, María Concepción Izquierdo, Beatriz Santamaria, Belén Picatoste, Susana Carrasco, Oscar Lorenzo, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz. Endogenous NAMPT dampens chemokine expression and apoptotic responses in stressed tubular cells.
Biochimica et biophysica acta.
2014 Feb; 1842(2):293-303. doi:
10.1016/j.bbadis.2013.11.022. [PMID: 24287278] - Ling Liu, Ping Wang, Canxin Liang, Dongwei He, Ying Yu, Xinwei Liu. Distinct effects of Nampt inhibition on mild and severe models of lipopolysaccharide-induced myocardial impairment.
International immunopharmacology.
2013 Oct; 17(2):342-9. doi:
10.1016/j.intimp.2013.06.017. [PMID: 23831038] - Xiaozhang Zheng, Paul Bauer, Timm Baumeister, Alexandre J Buckmelter, Maureen Caligiuri, Karl H Clodfelter, Bingsong Han, Yen-Ching Ho, Nikolai Kley, Jian Lin, Dominic J Reynolds, Geeta Sharma, Chase C Smith, Zhongguo Wang, Peter S Dragovich, Janet Gunzner-Toste, Bianca M Liederer, Justin Ly, Thomas O'Brien, Angela Oh, Leslie Wang, Weiru Wang, Yang Xiao, Mark Zak, Guiling Zhao, Po-Wai Yuen, Kenneth W Bair. Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.
Journal of medicinal chemistry.
2013 Aug; 56(16):6413-33. doi:
10.1021/jm4008664. [PMID: 23859118] - Sathisha Upparahalli Venkateshaiah, Sharmin Khan, Wen Ling, Rakesh Bam, Xin Li, Frits van Rhee, Saad Usmani, Bart Barlogie, Joshua Epstein, Shmuel Yaccoby. NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity.
Experimental hematology.
2013 Jun; 41(6):547-557.e2. doi:
10.1016/j.exphem.2013.02.008. [PMID: 23435312] - Michele Cea, Antonia Cagnetta, Franco Patrone, Alessio Nencioni, Marco Gobbi, Kenneth C Anderson. Intracellular NAD(+) depletion induces autophagic death in multiple myeloma cells.
Autophagy.
2013 Mar; 9(3):410-2. doi:
10.4161/auto.22866. [PMID: 23221771] - Li-Ying Liu, Feng Wang, Xia-Yan Zhang, Peng Huang, Yun-Bi Lu, Er-Qing Wei, Wei-Ping Zhang. Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases.
PloS one.
2012; 7(10):e44933. doi:
10.1371/journal.pone.0044933. [PMID: 23071504] - Laura Evans, Anwen S Williams, Anthony J Hayes, Simon A Jones, Mari Nowell. Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced arthritis.
Arthritis and rheumatism.
2011 Jul; 63(7):1866-77. doi:
10.1002/art.30338. [PMID: 21400478] - Hyun You, Hyung-Seop Youn, Isak Im, Man-Ho Bae, Sang-Kook Lee, Hyojin Ko, Soo Hyun Eom, Yong-Chul Kim. Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents.
European journal of medicinal chemistry.
2011 Apr; 46(4):1153-64. doi:
10.1016/j.ejmech.2011.01.034. [PMID: 21330015] - Gabriele Zoppoli, Michele Cea, Debora Soncini, Floriana Fruscione, Justine Rudner, Eva Moran, Irene Caffa, Davide Bedognetti, Giulia Motta, Riccardo Ghio, Fabio Ferrando, Alberto Ballestrero, Silvio Parodi, Claus Belka, Franco Patrone, Santina Bruzzone, Alessio Nencioni. Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.
Experimental hematology.
2010 Nov; 38(11):979-88. doi:
10.1016/j.exphem.2010.07.013. [PMID: 20696207] - Yankun Li, Yuan Zhang, Bernhard Dorweiler, Dongying Cui, Tao Wang, Connie W Woo, Cynthia S Brunkan, Cynthia Wolberger, Shin-ichiro Imai, Ira Tabas. Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism.
The Journal of biological chemistry.
2008 Dec; 283(50):34833-43. doi:
10.1074/jbc.m805866200. [PMID: 18945671] - Hye Kyoung Song, Mi Hwa Lee, Bo Kyung Kim, Yun Gyu Park, Gang Jee Ko, Young Sun Kang, Jee Young Han, Sang Youb Han, Kum Hyun Han, Hyoung Kyu Kim, Dae Ryong Cha. Visfatin: a new player in mesangial cell physiology and diabetic nephropathy.
American journal of physiology. Renal physiology.
2008 Nov; 295(5):F1485-94. doi:
10.1152/ajprenal.90231.2008. [PMID: 18768589] - Richard A Billington, Armando A Genazzani, Cristina Travelli, Fabrizio Condorelli. NAD depletion by FK866 induces autophagy.
Autophagy.
2008 Apr; 4(3):385-7. doi:
10.4161/auto.5635. [PMID: 18227641] - Richard A Billington, Cristina Travelli, Emanuela Ercolano, Ubaldina Galli, Cintia Blasi Roman, Ambra A Grolla, Pier Luigi Canonico, Fabrizio Condorelli, Armando A Genazzani. Characterization of NAD uptake in mammalian cells.
The Journal of biological chemistry.
2008 Mar; 283(10):6367-74. doi:
10.1074/jbc.m706204200. [PMID: 18180302] - Kyle Holen, Leonard B Saltz, Ellen Hollywood, Konrad Burk, Axel-Rainer Hanauske. The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor.
Investigational new drugs.
2008 Feb; 26(1):45-51. doi:
10.1007/s10637-007-9083-2. [PMID: 17924057] - Joachim Drevs, Roland Löser, Benno Rattel, Norbert Esser. Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma.
Anticancer research.
2003 Nov; 23(6C):4853-8. doi:
NULL. [PMID: 14981935]