Taribavirin (BioDeep_00000837804)
Metabolite Card
Taribavirin
Formula: C8H13N5O4 (243.0967)
Chinese Names:
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Molecular Structure
SMILES: C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=N)N
InChI: InChI=1S/C8H13N5O4/c9-6(10)7-11-2-13(12-7)8-5(16)4(15)3(1-14)17-8/h2-5,8,14-16H,1H2,(H3,9,10)/t3-,4-,5-,8-/m1/s1
Description
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Synonyms
1 synonym names
Cross Reference
5 cross reference id
- ChEBI: CHEBI:134989
- PubChem: 451448
- DrugBank: DB06408
- ChEMBL: CHEMBL2111108
- CAS: 119567-79-2
Classification Terms
Related Pathways
Reactome(0)
BioCyc(0)
PlantCyc(0)
Biological Process
0 related biological process reactions.
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 organism taxonomy source information
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| Sub-cellular location | Genes |
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Literature Reference
- Ahmed A Abd-Rabou, Dhruba J Bharali, Shaker A Mousa. Viramidine-Loaded Galactosylated Nanoparticles Induce Hepatic Cancer Cell Apoptosis and Inhibit Angiogenesis.
Applied biochemistry and biotechnology.
2020 Jan; 190(1):305-324. doi:
10.1007/s12010-019-03090-2. [PMID: 31346920] - Ahmed A Abd-Rabou, Dhruba J Bharali, Shaker A Mousa. Taribavirin and 5-Fluorouracil-Loaded Pegylated-Lipid Nanoparticle Synthesis, p38 Docking, and Antiproliferative Effects on MCF-7 Breast Cancer.
Pharmaceutical research.
2018 Feb; 35(4):76. doi:
10.1007/s11095-017-2283-3. [PMID: 29488022] - I D Konstantinova, I V Fateev, G A Galegov, P G Deriabin, A G Botikov, I S Muzyka, D K L'vov, A I Miroshnikov. [The arsenolysis reaction in the biotechnological method of synthesis of the ribavirin. Inhibition of reproduction of influenza A virus with the combination of ribavirin and ozeltamivir in experiments in vitro and in vivo].
Bioorganicheskaia khimiia.
2013 Sep; 39(5):594-603. doi:
10.1134/s1068162013050099. [PMID: 25702418] - Eva A Operskalski, Andrea Kovacs. HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies.
Current HIV/AIDS reports.
2011 Mar; 8(1):12-22. doi:
10.1007/s11904-010-0071-3. [PMID: 21221855] - Ashik Hayat, Ahmad Mitwalli. Hepatitis C and kidney disease.
Hepatitis research and treatment.
2010; 2010(?):534327. doi:
10.1155/2010/534327. [PMID: 21188196] - Robert G Gish, Sanjeev Arora, K Rajender Reddy, David R Nelson, Christopher O'Brien, Yi Xu, Brian Murphy. Virological response and safety outcomes in therapy-nai ve patients treated for chronic hepatitis C with taribavirin or ribavirin in combination with pegylated interferon alfa-2a: a randomized, phase 2 study.
Journal of hepatology.
2007 Jul; 47(1):51-9. doi:
10.1016/j.jhep.2007.02.018. [PMID: 17470380] - Jean-Michel Pawlotsky. [New therapeutic strategies in chronic hepatitis C].
Gastroenterologie clinique et biologique.
2006 Aug; 30(8-9):1009-11. doi:
10.1016/s0399-8320(06)73375-9. [PMID: 17075451] - Chin-Chung Lin, Christine Xu, Nanqun Zhu, Li-Tain Yeh. Absorption, metabolism, and excretion of [14C]viramidine in humans.
Antimicrobial agents and chemotherapy.
2006 Jul; 50(7):2368-73. doi:
10.1128/aac.00118-06. [PMID: 16801414] - Yifei Liu, Christine Xu, Rongzi Yan, Charmaine Lim, Li-Tain Yeh, Chin-chung Lin. Sensitive and specific LC-MS/MS method for the simultaneous measurements of viramidine and ribavirin in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Feb; 832(1):17-23. doi:
10.1016/j.jchromb.2005.12.034. [PMID: 16455313] - Jim Zhen Wu, Li-Tain Yeh, Chin-Chung Lin, Zhi Hong. Conversion of viramidine to ribavirin in vivo by adenosine deaminase and its inhibition by 2'-deoxycoformycin.
Antiviral chemistry & chemotherapy.
2006; 17(1):33-9. doi:
10.1177/095632020601700105. [PMID: 16542004] - Sanjee Aora, Christine Xu, Alice Teng, Janet Peterson, Li-Tain Yeh, Robert Gish, Daryl Lau, Stephen Rossi, Chin-chung Lin. Ascending multiple-dose pharmacokinetics of viramidine, a prodrug of ribavirin, in adult subjects with compensated hepatitis C infection.
Journal of clinical pharmacology.
2005 Mar; 45(3):275-85. doi:
10.1177/0091270004270152. [PMID: 15703363] - Chin-Chung Lin, Lee Philips, Christine Xu, Li-Tain Yeh. Pharmacokinetics and safety of viramidine, a prodrug of ribavirin, in healthy volunteers.
Journal of clinical pharmacology.
2004 Mar; 44(3):265-75. doi:
10.1177/0091270004262974. [PMID: 14973309] - Chin-Chung Lin, Kenneth Luu, David Lourenco, Li-Tain Yeh. Pharmacokinetics and metabolism of [14C]viramidine in rats and cynomolgus monkeys.
Antimicrobial agents and chemotherapy.
2003 Aug; 47(8):2458-63. doi:
10.1128/aac.47.8.2458-2463.2003. [PMID: 12878505] - Chin-chung Lin, Li-Tain Yeh, Domenico Vitarella, Zhi Hong. Viramidine, a prodrug of ribavirin, shows better liver-targeting properties and safety profiles than ribavirin in animals.
Antiviral chemistry & chemotherapy.
2003 May; 14(3):145-52. doi:
10.1177/095632020301400304. [PMID: 14521331] - R W Sidwell, J H Huffman, D L Barnard, D F Smee, R P Warren, M A Chirigos, M Kende, J Huggins. Antiviral and immunomodulating inhibitors of experimentally-induced Punta Toro virus infections.
Antiviral research.
1994 Oct; 25(2):105-22. doi:
10.1016/0166-3542(94)90100-7. [PMID: 7847873] - D F Smee, J Gilbert, J A Leonhardt, B B Barnett, J H Huggins, R W Sidwell. Treatment of lethal Pichinde virus infections in weanling LVG/Lak hamsters with ribavirin, ribamidine, selenazofurin, and ampligen.
Antiviral research.
1993 Jan; 20(1):57-70. doi:
10.1016/0166-3542(93)90059-r. [PMID: 8384433] - R W Sidwell, J H Huffman, D L Barnard, D Y Pifat. Effects of ribamidine, a 3-carboxamidine derivative of ribavirin, on experimentally induced Phlebovirus infections.
Antiviral research.
1988 Dec; 10(4-5):193-207. doi:
10.1016/0166-3542(88)90031-9. [PMID: 2976263]
