Vofopitant (BioDeep_00000837794)
代谢物信息卡片
化学式: C21H23F3N6O (432.1885344)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C(C=C1)N2C(=NN=N2)C(F)(F)F)CNC3CCCNC3C4=CC=CC=C4
InChI: InChI=1S/C21H23F3N6O/c1-31-18-10-9-16(30-20(21(22,23)24)27-28-29-30)12-15(18)13-26-17-8-5-11-25-19(17)14-6-3-2-4-7-14/h2-4,6-7,9-10,12,17,19,25-26H,5,8,11,13H2,1H3/t17-,19-/m0/s1
描述信息
D018377 - Neurotransmitter Agents > D064729 - Neurokinin-1 Receptor Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A Frick, F Åhs, Å M Palmquist, A Pissiota, U Wallenquist, M Fernandez, M Jonasson, L Appel, Ö Frans, M Lubberink, T Furmark, L von Knorring, M Fredrikson. Overlapping expression of serotonin transporters and neurokinin-1 receptors in posttraumatic stress disorder: a multi-tracer PET study.
Molecular psychiatry.
2016 10; 21(10):1400-7. doi:
10.1038/mp.2015.180. [PMID: 26619809] - Tulla Spinelli, Selma Calcagnile, Claudio Giuliano, Giorgia Rossi, Corinna Lanzarotti, Stuart Mair, Lloyd Stevens, Ian Nisbet. Netupitant PET imaging and ADME studies in humans.
Journal of clinical pharmacology.
2014 Jan; 54(1):97-108. doi:
10.1002/jcph.198. [PMID: 24122871] - Stefano Zamuner, Eugenii A Rabiner, Sofia A Fernandes, Massimo Bani, Roger N Gunn, Roberto Gomeni, Emilangelo Ratti, Vincent J Cunningham. A pharmacokinetic PET study of NK₁ receptor occupancy.
European journal of nuclear medicine and molecular imaging.
2012 Feb; 39(2):226-35. doi:
10.1007/s00259-011-1954-2. [PMID: 21993526] - Stefano Zamuner, Roberto Gomeni, Alan Bye. Estimate the time varying brain receptor occupancy in PET imaging experiments using non-linear fixed and mixed effect modeling approach.
Nuclear medicine and biology.
2002 Jan; 29(1):115-23. doi:
10.1016/s0969-8051(01)00275-x. [PMID: 11786282] - A B Alfieri, L X Cubeddu. Nitric oxide and NK(1)-tachykinin receptors in cyclophosphamide-induced cystitis, in rats.
The Journal of pharmacology and experimental therapeutics.
2000 Nov; 295(2):824-9. doi:
NULL. [PMID: 11046124] - A B Alfieri, L X Cubeddu. Role of NK1 receptors on cisplatin-induced nephrotoxicity in the rat.
Naunyn-Schmiedeberg's archives of pharmacology.
2000 Mar; 361(3):334-8. doi:
10.1007/s002109900196. [PMID: 10731048] - P J Goadsby, K L Hoskin, Y E Knight. Substance P blockade with the potent and centrally acting antagonist GR205171 does not effect central trigeminal activity with superior sagittal sinus stimulation.
Neuroscience.
1998 Sep; 86(1):337-43. doi:
10.1016/s0306-4522(98)00013-x. [PMID: 9692766] - J S Polley, P J Gaskin, M J Perren, H E Connor, P Ward, D T Beattie. The activity of GR205171, a potent non-peptide tachykinin NK1 receptor antagonist, in the trigeminovascular system.
Regulatory peptides.
1997 Jan; 68(1):23-9. doi:
10.1016/s0167-0115(96)00137-1. [PMID: 9094751]