Dasotraline (BioDeep_00000837790)
代谢物信息卡片
化学式: C16H15Cl2N (291.058149)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(C2=CC=CC=C2C1C3=CC(=C(C=C3)Cl)Cl)N
InChI: InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2/t11-,16+/m0/s1
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D10700
- PubChem: 9947999
- DrugBank: DB12305
- ChEMBL: CHEMBL3301595
- CAS: 675126-05-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Estela Skende, Nancy Zheng, Yu-Luan Chen. A sensitive liquid chromatography-tandem mass spectrometry method for quantitative determination of dasotraline in human plasma and its clinical application.
Journal of pharmaceutical and biomedical analysis.
2020 Nov; 191(?):113611. doi:
10.1016/j.jpba.2020.113611
. [PMID: 33007733] - Robert Lew, Cristian C Constantinescu, Daniel Holden, Richard E Carson, Vincent Carroll, Gerald Galluppi, Kenneth S Koblan, Seth C Hopkins. The rate of dasotraline brain entry is slow following intravenous administration.
Psychopharmacology.
2020 Nov; 237(11):3435-3446. doi:
10.1007/s00213-020-05623-8
. [PMID: 32813030] - Pankhuree Vandana, Eugene Arnold. Dasotraline in ADHD: novel or me too drug?.
Expert review of neurotherapeutics.
2019 04; 19(4):311-315. doi:
10.1080/14737175.2019.1593826
. [PMID: 30871381] - Seth C Hopkins, Soujanya Sunkaraneni, Estela Skende, Jeremy Hing, Julie A Passarell, Antony Loebel, Kenneth S Koblan. Pharmacokinetics and Exposure-Response Relationships of Dasotraline in the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults.
Clinical drug investigation.
2016 Feb; 36(2):137-46. doi:
10.1007/s40261-015-0358-7
. [PMID: 26597180] - Kenneth S Koblan, Seth C Hopkins, Kaushik Sarma, Fengbin Jin, Robert Goldman, Scott H Kollins, Antony Loebel. Dasotraline for the Treatment of Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial in Adults.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2015 Nov; 40(12):2745-52. doi:
10.1038/npp.2015.124
. [PMID: 25948101] - Christine DeLorenzo, Sarah Lichenstein, Karen Schaefer, Judith Dunn, Randall Marshall, Lisa Organisak, Jahnavi Kharidia, Brigitte Robertson, J John Mann, Ramin V Parsey. SEP-225289 serotonin and dopamine transporter occupancy: a PET study.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2011 Jul; 52(7):1150-5. doi:
10.2967/jnumed.110.084525
. [PMID: 21680689]