Darinaparsin (BioDeep_00000837777)

   


代谢物信息卡片


Darinaparsin

化学式: C12H22AsN3O6S (411.0445212)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C[As](C)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
InChI: InChI=1S/C12H22AsN3O6S/c1-13(2)23-6-8(11(20)15-5-10(18)19)16-9(17)4-3-7(14)12(21)22/h7-8H,3-6,14H2,1-2H3,(H,15,20)(H,16,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1

描述信息

C274 - Antineoplastic Agent > C177298 - Mitochondrial Targeting Antineoplastic Agent

同义名列表

1 个代谢物同义名

Darinaparsin



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Michinori Ogura, Won-Seog Kim, Toshiki Uchida, Naokuni Uike, Youko Suehiro, Kenichi Ishizawa, Hirokazu Nagai, Fumiko Nagahama, Yusuke Sonehara, Kensei Tobinai. Phase I studies of darinaparsin in patients with relapsed or refractory peripheral T-cell lymphoma: a pooled analysis of two phase I studies conducted in Japan and Korea. Japanese journal of clinical oncology. 2021 Feb; 51(2):218-227. doi: 10.1093/jjco/hyaa177. [PMID: 33051668]
  • Trinath Chowdhury, Gourisankar Roymahapatra, Santi M Mandal. In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA Dependent RNA polymerase (RdRp) and Essential Proteases. Infectious disorders drug targets. 2021; 21(4):608-618. doi: 10.2174/1871526520666200727153643. [PMID: 32718300]
  • Ayaka Kato, Yayoi Kobayashi, Osamu Udagawa, Seishiro Hirano. Pharmacodynamics of S-dimethylarsino-glutathione, a putative metabolic intermediate of inorganic arsenic, in mice. Biochemical pharmacology. 2017 Feb; 126(?):79-86. doi: 10.1016/j.bcp.2016.11.020. [PMID: 27889539]
  • Szabina Stice, Guangliang Liu, Shannon Matulis, Lawrence H Boise, Yong Cai. Determination of multiple human arsenic metabolites employing high performance liquid chromatography inductively coupled plasma mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jan; 1009-1010(?):55-65. doi: 10.1016/j.jchromb.2015.12.008. [PMID: 26708625]
  • Rafael Kramann, Susanne V Fleig, Rebekka K Schneider, Steven L Fabian, Derek P DiRocco, Omar Maarouf, Janewit Wongboonsin, Yoichiro Ikeda, Dirk Heckl, Steven L Chang, Helmut G Rennke, Sushrut S Waikar, Benjamin D Humphreys. Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis. The Journal of clinical investigation. 2015 Aug; 125(8):2935-51. doi: 10.1172/jci74929. [PMID: 26193634]
  • Lucy Yehiayan, Szabina Stice, Guangliang Liu, Shannon Matulis, Lawrence H Boise, Yong Cai. Dimethylarsinothioyl glutathione as a metabolite in human multiple myeloma cell lines upon exposure to Darinaparsin. Chemical research in toxicology. 2014 May; 27(5):754-64. doi: 10.1021/tx400386c. [PMID: 24624948]
  • R A Burgos, J L Hancke, J C Bertoglio, V Aguirre, S Arriagada, M Calvo, D D Cáceres. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clinical rheumatology. 2009 Aug; 28(8):931-46. doi: 10.1007/s10067-009-1180-5. [PMID: 19408036]
  • Apostolia Maria Tsimberidou, Luis H Camacho, Srdan Verstovsek, Chaan Ng, David S Hong, Cynthia K Uehara, Catalina Gutierrez, Shawn Daring, Jan Stevens, Philip B Komarnitsky, Brian Schwartz, Razelle Kurzrock. A phase I clinical trial of darinaparsin in patients with refractory solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Jul; 15(14):4769-76. doi: 10.1158/1078-0432.ccr-08-2984. [PMID: 19584162]
  • Katerina Kanaki, Spiros A Pergantis. Development of mass spectrometric methods for detecting arsenic-glutathione complexes. Journal of the American Society for Mass Spectrometry. 2008 Oct; 19(10):1559-67. doi: 10.1016/j.jasms.2008.06.011. [PMID: 18657439]
  • T Sakurai, C Kojima, Y Kobayashi, S Hirano, M H Sakurai, M P Waalkes, S Himeno. Toxicity of a trivalent organic arsenic compound, dimethylarsinous glutathione in a rat liver cell line (TRL 1215). British journal of pharmacology. 2006 Dec; 149(7):888-97. doi: 10.1038/sj.bjp.0706899. [PMID: 17043674]
  • Seishiro Hirano, Yayoi Kobayashi. Cytotoxic effects of S-(dimethylarsino)-glutathione: a putative intermediate metabolite of inorganic arsenicals. Toxicology. 2006 Oct; 227(1-2):45-52. doi: 10.1016/j.tox.2006.07.009. [PMID: 16945460]
  • C H Banks, J R Daniel, R A Zingaro. Biomolecules bearing the S- or SeAsMe2 function: amino acid and steroid derivatives. Journal of medicinal chemistry. 1979 May; 22(5):572-5. doi: 10.1021/jm00191a021. [PMID: 458808]