Tonapofylline (BioDeep_00000837771)
代谢物信息卡片
化学式: C22H32N4O4 (416.2423)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C34CCC(CC3)(CC4)CCC(=O)O
InChI: InChI=1S/C22H32N4O4/c1-3-13-25-17-16(18(29)26(14-4-2)20(25)30)23-19(24-17)22-10-7-21(8-11-22,9-12-22)6-5-15(27)28/h3-14H2,1-2H3,(H,23,24)(H,27,28)
描述信息
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure[1][2].
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:177398
- KEGGdrug: D09684
- PubChem: 216466
- DrugBank: DB12569
- ChEMBL: CHEMBL414157
- ChEMBL: CHEMBL386974
- CAS: 340021-17-2
- medchemexpress: HY-14873
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Stevan P Tofovic, Eman M Salah, Glenn J Smits, Eric T Whalley, Barry Ticho, Aaron Deykin, Edwin K Jackson. Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction.
The Journal of pharmacology and experimental therapeutics.
2016 Feb; 356(2):333-40. doi:
10.1124/jpet.115.228841. [PMID: 26585572] - Zhaoyang Li, Liang-Shang Gan, Thomas Marbury, Kenneth C Lasseter, Amy Natarajan, Scott Stecher, Dong Wei, Liyu Yang, Daniel Freedman, Aaron Deykin. Pharmacokinetics of oral tonapofylline and its acyl-glucuronide metabolite in patients with mild and moderate hepatic impairment.
Journal of clinical pharmacology.
2012 Apr; 52(4):543-51. doi:
10.1177/0091270011400413. [PMID: 21610206] - Stephen S Gottlieb, Barry Ticho, Aaron Deykin, William T Abraham, David Denofrio, Stuart D Russell, Douglas Chapman, William Smith, Steven Goldman, Ignatius Thomas. Effects of BG9928, an adenosine A₁ receptor antagonist, in patients with congestive heart failure.
Journal of clinical pharmacology.
2011 Jun; 51(6):899-907. doi:
10.1177/0091270010375957. [PMID: 20926754] - Alan Gill, Kathleen Wortham, Don Costa, Wendell Davis, Barry Ticho, Eric Whalley. Protective effect of tonapofylline (BG9928), an adenosine A1 receptor antagonist, against cisplatin-induced acute kidney injury in rats.
American journal of nephrology.
2009; 30(6):521-6. doi:
10.1159/000248762. [PMID: 19828940] - Mustafa M Dohadwala, Michael M Givertz. Role of adenosine antagonism in the cardiorenal syndrome.
Cardiovascular therapeutics.
2008; 26(4):276-86. doi:
10.1111/j.1755-5922.2008.00059.x. [PMID: 19035879] - Barry Greenberg, Ignatius Thomas, Dorothy Banish, Steven Goldman, Edward Havranek, Barry M Massie, Ying Zhu, Barry Ticho, William T Abraham. Effects of multiple oral doses of an A1 adenosine antagonist, BG9928, in patients with heart failure: results of a placebo-controlled, dose-escalation study.
Journal of the American College of Cardiology.
2007 Aug; 50(7):600-6. doi:
10.1016/j.jacc.2007.03.059. [PMID: 17692744]
