Nemonoxacin (BioDeep_00000837770)
代谢物信息卡片
化学式: C20H25N3O4 (371.184497)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC(CN(C1)C2=C(C3=C(C=C2)C(=O)C(=CN3C4CC4)C(=O)O)OC)N
InChI: InChI=1S/C20H25N3O4/c1-11-7-12(21)9-22(8-11)16-6-5-14-17(19(16)27-2)23(13-3-4-13)10-15(18(14)24)20(25)26/h5-6,10-13H,3-4,7-9,21H2,1-2H3,(H,25,26)/t11-,12-/m0/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:136053
- PubChem: 11993740
- DrugBank: DB06600
- ChEMBL: CHEMBL1213456
- CAS: 378746-64-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yi Li, Jianda Lu, Yue Kang, Xiaoyong Xu, Xin Li, Yuancheng Chen, Kun Wang, Xiaofen Liu, Yaxin Fan, Hailan Wu, Yu Wang, Jiali Hu, Jicheng Yu, Jufang Wu, Beining Guo, Yingyuan Zhang, Xin Zeng, Ming Zhao, Jun Xue, Jing Zhang. Nemonoxacin dosage adjustment in patients with severe renal impairment based on population pharmacokinetic and pharmacodynamic analysis.
British journal of clinical pharmacology.
2021 12; 87(12):4636-4647. doi:
10.1111/bcp.14881. [PMID: 33928669] - Yue Kang, Yi Li, Fengyan Xu, Jing Zhang, Kun Wang, Yuancheng Chen, Jufang Wu, Beining Guo, Jicheng Yu, Yingyuan Zhang. Population Pharmacokinetics Study of Nemonoxacin Among Chinese Patients With Moderate Hepatic Impairment.
Clinical therapeutics.
2019 03; 41(3):505-517.e0. doi:
10.1016/j.clinthera.2019.01.015. [PMID: 30819510] - Caiyun Zhao, Yuan Lv, Xiangyan Li, Fang Hou, Xuzhu Ma, Minji Wei, Zisheng Kang, Lanqing Cui, Yahong Xia, Yan Liu, Jihong Tian. Effects of Nemonoxacin on Thorough ECG QT/QTc Interval: A Randomized, Placebo- and Positive-controlled Crossover Study in Healthy Chinese Adults.
Clinical therapeutics.
2018 06; 40(6):983-992. doi:
10.1016/j.clinthera.2018.04.014. [PMID: 29803534] - Yi-Fan Zhang, Xiao-Jian Dai, Yong Yang, Xiao-Yan Chen, Ting Wang, Yun-Biao Tang, Cheng-Yuan Tsai, Li-Wen Chang, Yu-Ting Chang, Da-Fang Zhong. Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers.
Drug design, development and therapy.
2016; 10(?):357-70. doi:
10.2147/dddt.s95934. [PMID: 26855561] - Gaoli He, Beining Guo, Jicheng Yu, Jing Zhang, Xiaojie Wu, Guoying Cao, Yaoguo Shi, Cheng-Yuan Tsai. Determination of a novel nonfluorinated quinolone, nemonoxacin, in human feces and its glucuronide conjugate in human urine and feces by high-performance liquid chromatography-triple quadrupole mass spectrometry.
Biomedical chromatography : BMC.
2015 May; 29(5):739-48. doi:
10.1002/bmc.3350. [PMID: 25322721] - Yi-fan Zhang, Xiao-jian Dai, Ting Wang, Xiao-yan Chen, Li Liang, Hua Qiao, Cheng-yuan Tsai, Li-wen Chang, Ping-ting Huang, Chiung-yuan Hsu, Yu-ting Chang, Chen-en Tsai, Da-fang Zhong. Effects of an Al(3+)- and Mg(2+)-containing antacid, ferrous sulfate, and calcium carbonate on the absorption of nemonoxacin (TG-873870) in healthy Chinese volunteers.
Acta pharmacologica Sinica.
2014 Dec; 35(12):1586-92. doi:
10.1038/aps.2014.95. [PMID: 25327812] - Guo-Ying Cao, Jing Zhang, Ying-Yuan Zhang, Bei-Ning Guo, Ji-Cheng Yu, Xiao-Jie Wu, Yuan-Cheng Chen, Ju-Fang Wu, Yao-Guo Shi. Safety, tolerability, and pharmacokinetics of intravenous nemonoxacin in healthy chinese volunteers.
Antimicrobial agents and chemotherapy.
2014 Oct; 58(10):6116-21. doi:
10.1128/aac.02972-14. [PMID: 25092690] - Beining Guo, Jing Zhang, Jicheng Yu, Xiaojie Wu, Yaoguo Shi, Cheng-Yuan Tsai. A liquid chromatography-tandem mass spectrometry assay for the determination of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, in human plasma and urine and its application to a single-dose pharmacokinetic study in healthy Chinese volunteers.
Biomedical chromatography : BMC.
2012 Nov; 26(11):1333-40. doi:
10.1002/bmc.2699. [PMID: 22275159] - Beining Guo, Xiaojie Wu, Yingyuan Zhang, Yaoguo Shi, Jicheng Yu, Guoying Cao, Jing Zhang. Safety and clinical pharmacokinetics of nemonoxacin, a novel non-fluorinated quinolone, in healthy Chinese volunteers following single and multiple oral doses.
Clinical drug investigation.
2012 Jul; 32(7):475-86. doi:
10.2165/11632780-000000000-00000. [PMID: 22650326] - David T Chung, Cheng-Yuan Tsai, Shu-Jen Chen, Li-Wen Chang, Chi-Hsin R King, Ching-Hung Hsu, Kit-Mui Chiu, Hao-Chen Tan, Yu-Ting Chang, Ming-Chu Hsu. Multiple-dose safety, tolerability, and pharmacokinetics of oral nemonoxacin (TG-873870) in healthy volunteers.
Antimicrobial agents and chemotherapy.
2010 Jan; 54(1):411-7. doi:
10.1128/aac.00683-09. [PMID: 19884374] - Luke Lin, Li-Wen Chang, Cheng-Yuan Tsai, Ching-Hung Hsu, David T Chung, William S Aronstein, Funmi Ajayi, Barbara Kuzmak, Robert A Lyon. Dose escalation study of the safety, tolerability, and pharmacokinetics of nemonoxacin (TG-873870), a novel potent broad-spectrum nonfluorinated quinolone, in healthy volunteers.
Antimicrobial agents and chemotherapy.
2010 Jan; 54(1):405-10. doi:
10.1128/aac.00682-09. [PMID: 19884368]