Dexelvucitabine (BioDeep_00000837766)
代谢物信息卡片
化学式: C9H10FN3O3 (227.0706)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(OC1CO)N2C=C(C(=NC2=O)N)F
InChI: InChI=1S/C9H10FN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h1-3,5,7,14H,4H2,(H2,11,12,15)/t5-,7+/m0/s1
描述信息
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D06580
- PubChem: 64973
- DrugBank: DB12470
- ChEMBL: CHEMBL109831
- CAS: 134379-77-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Philippe Colucci, John C Pottage, Heather Robison, Jacques Turgeon, Dirk Schürmann, I M Hoepelman, Murray P Ducharme. Multiple-dose pharmacokinetic behavior of elvucitabine, a nucleoside reverse transcriptase inhibitor, administered over 21 days with lopinavir-ritonavir in human immunodeficiency virus type 1-infected subjects.
Antimicrobial agents and chemotherapy.
2009 Feb; 53(2):662-9. doi:
10.1128/aac.00907-08. [PMID: 19015343] - Philippe Colucci, John C Pottage, Heather Robison, Jacques Turgeon, Murray P Ducharme. Effect of a single dose of ritonavir on the pharmacokinetic behavior of elvucitabine, a nucleoside reverse transcriptase inhibitor, administered in healthy volunteers.
Antimicrobial agents and chemotherapy.
2009 Feb; 53(2):646-50. doi:
10.1128/aac.00905-08. [PMID: 19015353] - Lieven J Stuyver, Tamara R McBrayer, Dirk Schürmann, Irena Kravec, Amanda Beard, Leanne Cartee, Raymond F Schinazi, Abel De La Rosa, Robert L Murphy, Michael J Otto. Potent antiviral effect of reverset in HIV-1-infected adults following a single oral dose.
Antiviral therapy.
2004 Aug; 9(4):529-36. doi:
NULL. [PMID: 15456084] - Lieven J Stuyver, Stefania Lostia, Marjorie Adams, Judy S Mathew, Balakrishna S Pai, Jason Grier, Phillip M Tharnish, Yongseok Choi, Youhoon Chong, Hyunah Choo, Chung K Chu, Michael J Otto, Raymond F Schinazi. Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.
Antimicrobial agents and chemotherapy.
2002 Dec; 46(12):3854-60. doi:
10.1128/aac.46.12.3854-3860.2002. [PMID: 12435688] - Raymond F Schinazi, John Mellors, Holly Bazmi, Sharon Diamond, Sena Garber, Karen Gallagher, Romas Geleziunas, Ron Klabe, Michael Pierce, Marlene Rayner, Jing-Tao Wu, Hangchun Zhang, Jennifer Hammond, Lee Bacheler, Douglas J Manion, Michael J Otto, Lieven Stuyver, George Trainor, Dennis C Liotta, Susan Erickson-Viitanen. DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants.
Antimicrobial agents and chemotherapy.
2002 May; 46(5):1394-401. doi:
10.1128/aac.46.5.1394-1401.2002. [PMID: 11959574] - Y C Cheng. Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers.
Cancer letters.
2001 Jan; 162 Suppl(?):S33-S37. doi:
10.1016/s0304-3835(00)00650-9. [PMID: 11164188] - L Ma, S J Hurwitz, J Shi, J J Mcatee, D C Liotta, H M McClure, R F Schinazi. Pharmacokinetics of the antiviral agent beta-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy.
1999 Feb; 43(2):381-4. doi:
10.1128/aac.43.2.381. [PMID: 9925539]
