Dutogliptin (BioDeep_00000837760)

   


代谢物信息卡片


Dutogliptin

化学式: C10H20BN3O3 (241.15976400000002)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: B(C1CCCN1C(=O)CNC2CCNC2)(O)O
InChI: InChI=1S/C10H20BN3O3/c15-10(7-13-8-3-4-12-6-8)14-5-1-2-9(14)11(16)17/h8-9,12-13,16-17H,1-7H2/t8-,9+/m1/s1

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98086 - Dipeptidyl Peptidase-4 Inhibitor
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor

同义名列表

1 个代谢物同义名

Dutogliptin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Jean-Francois Marier, Mohamad-Samer Mouksassi, Nathalie H Gosselin, Jianke Li. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clinical pharmacology in drug development. 2014 07; 3(4):297-304. doi: 10.1002/cpdd.87. [PMID: 27128836]
  • Matteo Monami, Caterina Lamanna, Carla Maria Desideri, Edoardo Mannucci. DPP-4 inhibitors and lipids: systematic review and meta-analysis. Advances in therapy. 2012 Jan; 29(1):14-25. doi: 10.1007/s12325-011-0088-z. [PMID: 22215383]
  • Jianke Li, Kirsti Klemm, A Marie O'Farrell, Hans-Peter Guler, Julie M Cherrington, Sherwyn Schwartz, Teresa Boyea. Evaluation of the potential for pharmacokinetic and pharmacodynamic interactions between dutogliptin, a novel DPP4 inhibitor, and metformin, in type 2 diabetic patients. Current medical research and opinion. 2010 Aug; 26(8):2003-10. doi: 10.1185/03007995.2010.491266. [PMID: 20583949]
  • Baptist Gallwitz. New treatments in the management of type 2 diabetes: a critical appraisal of saxagliptin. Diabetes, metabolic syndrome and obesity : targets and therapy. 2010 May; 3(?):117-24. doi: 10.2147/dmsott.s4857. [PMID: 21437082]
  • H M R Pattzi, S Pitale, M Alpizar, C Bennett, A M O'Farrell, J Li, J M Cherrington, H-P Guler. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes, obesity & metabolism. 2010 Apr; 12(4):348-55. doi: 10.1111/j.1463-1326.2010.01195.x. [PMID: 20380656]
  • A Marie O'Farrell, Andre van Vliet, Khalid Abou Farha, Julie M Cherrington, David A Campbell, Xinqiang Li, Denise Hanway, Jianke Li, Hans-Peter Guler. Pharmacokinetic and pharmacodynamic assessments of the dipeptidyl peptidase-4 inhibitor PHX1149: double-blind, placebo-controlled, single- and multiple-dose studies in healthy subjects. Clinical therapeutics. 2007 Aug; 29(8):1692-705. doi: 10.1016/j.clinthera.2007.08.005. [PMID: 17919550]