Ecopipam (BioDeep_00000837758)

   


代谢物信息卡片


Ecopipam

化学式: C19H20ClNO (313.12333400000006)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCC2=CC(=C(C=C2C3C1CCC4=CC=CC=C34)O)Cl
InChI: InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

1 个代谢物同义名

Ecopipam



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Doran J Satanove, Simon Rahman, T M Vanessa Chan, Suelynn Ren, Paul B S Clarke. Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects. Psychopharmacology. 2021 Feb; 238(2):475-486. doi: 10.1007/s00213-020-05696-5. [PMID: 33150479]
  • Wei Yang, Adam C Munhall, Steven W Johnson. Dopamine Evokes a Trace Amine Receptor-dependent Inward Current that is Regulated by AMP Kinase in Substantia Nigra Dopamine Neurons. Neuroscience. 2020 02; 427(?):77-91. doi: 10.1016/j.neuroscience.2019.11.044. [PMID: 31883822]
  • Donald L Gilbert, Cathy L Budman, Harvey S Singer, Roger Kurlan, Richard E Chipkin. A D1 receptor antagonist, ecopipam, for treatment of tics in Tourette syndrome. Clinical neuropharmacology. 2014 Jan; 37(1):26-30. doi: 10.1097/wnf.0000000000000017. [PMID: 24434529]
  • Morgane Thomsen, F Scott Hall, George R Uhl, S Barak Caine. Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Jan; 29(4):1087-92. doi: 10.1523/jneurosci.4037-08.2009. [PMID: 19176817]
  • Wen-Lian Wu, Duane A Burnett, Richard Spring, William J Greenlee, Michelle Smith, Leonard Favreau, Ahmad Fawzi, Hongtao Zhang, Jean E Lachowicz. Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists. Journal of medicinal chemistry. 2005 Feb; 48(3):680-93. doi: 10.1021/jm030614p. [PMID: 15689153]
  • C C Lin, H K Kim, D Parker. Sensitive high-performance liquid chromatographic method for the determination of a benzonaphthazepine antipsychotic agent, SCH 39166, and its active metabolite, SCH 40853, in human plasma and its cross-validation with a gas chromatographic method. Journal of chromatography. B, Biomedical applications. 1996 Jul; 682(2):309-13. doi: 10.1016/0378-4347(96)00089-8. [PMID: 8844424]
  • R S Mansbach, S A Jortani, R L Balster. Discriminative stimulus effects of esteratic local anesthetics in squirrel monkeys. European journal of pharmacology. 1995 Feb; 274(1-3):167-73. doi: 10.1016/0014-2999(94)00733-n. [PMID: 7768269]
  • C E Tedford, V L Coffin, V Ruperto, M Cohen, R D McQuade, R Johnson, H K Kim, C C Lin. Determination of plasma and brain concentrations of SCH 39166 and their correlation to conditioned avoidance behavior in rats. Psychopharmacology. 1993; 113(2):199-204. doi: 10.1007/bf02245697. [PMID: 7855181]
  • J Hietala, T Seppäla, J Lappalainen, E Syvälahti. Quantification of SCH 39166, a novel selective D1 dopamine receptor antagonist, in rat brain and blood. Psychopharmacology. 1992; 106(4):455-8. doi: 10.1007/bf02244814. [PMID: 1349751]
  • R A Duffy, G Kaminska, R E Chipkin, R D McQuade. Selective up-regulation of D-1 dopamine receptors following chronic administration of SCH 39166 in primates. Pharmacology, biochemistry, and behavior. 1992 Jan; 41(1):235-8. doi: 10.1016/0091-3057(92)90089-x. [PMID: 1531704]
  • R K Sunahara, H C Guan, B F O'Dowd, P Seeman, L G Laurier, G Ng, S R George, J Torchia, H H Van Tol, H B Niznik. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr; 350(6319):614-9. doi: 10.1038/350614a0. [PMID: 1826762]
  • R E Chipkin, L C Iorio, V L Coffin, R D McQuade, J G Berger, A Barnett. Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity. The Journal of pharmacology and experimental therapeutics. 1988 Dec; 247(3):1093-102. doi: NULL. [PMID: 2905002]