Methylnaltrexone (BioDeep_00000837734)
代谢物信息卡片
Methylnaltrexone cation
化学式: C21H26NO4+ (356.1861736000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+]1(CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O)CC6CC6
InChI: InChI=1S/C21H25NO4/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13/h4-5,12,16,19,25H,2-3,6-11H2,1H3/p+1/t16-,19+,20+,21-,22-/m1/s1
描述信息
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists
C78272 - Agent Affecting Nervous System > C681 - Opiate Antagonist
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:136007
- PubChem: 5361918
- PubChem: 16089915
- DrugBank: DB06800
- ChEMBL: CHEMBL1186579
- ChEMBL: CHEMBL470617
- CAS: 916055-93-1
- CAS: 83387-25-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kim Juhani Blomqvist, Katarzyna Anna Dudek, Hanna Viisanen, Kert Mätlik, Fredrik Harry Gustav Ahlström, Jouko Laitila, Eija Anneli Kalso, Pekka Veli Rauhala, Tuomas Olavi Lilius. Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats.
Journal of neuroscience research.
2022 01; 100(1):329-338. doi:
10.1002/jnr.24638. [PMID: 32459013] - Cecilie Siggaard Knoph, Mathias Ellgaard Cook, Camilla Ann Fjelsted, Srdan Novovic, Michael Bau Mortensen, Liv Bjerre Juul Nielsen, Mark Berner Hansen, Jens Brøndum Frøkjær, Søren Schou Olesen, Asbjørn Mohr Drewes. Effects of the peripherally acting μ-opioid receptor antagonist methylnaltrexone on acute pancreatitis severity: study protocol for a multicentre double-blind randomised placebo-controlled interventional trial, the PAMORA-AP trial.
Trials.
2021 Dec; 22(1):940. doi:
10.1186/s13063-021-05885-3. [PMID: 34924020] - Francesco Franchi, Fabiana Rollini, Yongwhi Park, Jenny Hu, Megha Kureti, Jose Rivas Rios, Gabriel Faz, Dmitry Yaranov, Latonya Been, Andres M Pineda, Siva Suryadevara, Daniel Soffer, Martin M Zenni, Theodore A Bass, Dominick J Angiolillo. Effects of Methylnaltrexone on Ticagrelor-Induced Antiplatelet Effects in Coronary Artery Disease Patients Treated With Morphine.
JACC. Cardiovascular interventions.
2019 08; 12(16):1538-1549. doi:
10.1016/j.jcin.2019.05.028. [PMID: 31377269] - Dan Zhang, Jing-Yi Ma, Man Yang, Ming Deng, Huichen Liu. Pharmacokinetic study of methylnaltrexone after single and multiple subcutaneous administrations in healthy Chinese subjects.
Xenobiotica; the fate of foreign compounds in biological systems.
2018 Aug; 48(8):804-808. doi:
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Drug testing and analysis.
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Journal of the American Association for Laboratory Animal Science : JAALAS.
2017 Mar; 56(2):155-159. doi:
NULL. [PMID: 28315644] - Julia Kolbow, Christiane Modess, Danilo Wegner, Stefan Oswald, Martina Alice Maritz, Hélène Rey, Werner Weitschies, Werner Siegmund. Extended-release but not immediate-release and subcutaneous methylnaltrexone antagonizes the loperamide-induced delay of whole-gut transit time in healthy subjects.
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2014 Feb; 40(2):186-91. doi:
10.3109/03639045.2012.753899. [PMID: 23327357] - Jennifer Marie Lee, James Mooney. Methylnaltrexone in treatment of opioid-induced constipation in a pediatric patient.
The Clinical journal of pain.
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PloS one.
2012; 7(4):e35129. doi:
10.1371/journal.pone.0035129. [PMID: 22496900] - Stefan Oswald, Gitta Schumacher, Werner Siegmund. Quantitative determination of methylnaltrexone in human serum using liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2011 Dec; 56(5):1079-84. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2010 Apr; 38(4):606-16. doi:
10.1124/dmd.109.031179. [PMID: 20053817] - Patrick A Singleton, Nurbek Mambetsariev, Frances E Lennon, Biji Mathew, Jessica H Siegler, Liliana Moreno-Vinasco, Ravi Salgia, Jonathan Moss, Joe Gn Garcia. Methylnaltrexone potentiates the anti-angiogenic effects of mTOR inhibitors.
Journal of angiogenesis research.
2010 Feb; 2(1):5. doi:
10.1186/2040-2384-2-5. [PMID: 20298531] - Chun-Su Yuan, Chong-Zhi Wang, Sangeeta R Mehendale, Han H Aung, Adela Foo, Robert J Israel. Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model.
AIDS research and therapy.
2009 Aug; 6(?):19. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Pedro Boscan, Linda M Van Hoogmoed, Bruno H Pypendop, Thomas B Farver, Jack R Snyder. Pharmacokinetics of the opioid antagonist N-methylnaltrexone and evaluation of its effects on gastrointestinal tract function in horses treated or not treated with morphine.
American journal of veterinary research.
2006 Jun; 67(6):998-1004. doi:
10.2460/ajvr.67.6.998. [PMID: 16740093] - Chun-Su Yuan, Robert J Israel. Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects.
Expert opinion on investigational drugs.
2006 May; 15(5):541-52. doi:
10.1517/13543784.15.5.541. [PMID: 16634692] - Chun-Su Yuan, Harold Doshan, Martha R Charney, Michael O'connor, Theodore Karrison, S A Maleckar, Robert J Israel, Jonathan Moss. Tolerability, gut effects, and pharmacokinetics of methylnaltrexone following repeated intravenous administration in humans.
Journal of clinical pharmacology.
2005 May; 45(5):538-46. doi:
10.1177/0091270004273491. [PMID: 15831777] - Joachim Osinski, Anbao Wang, Ji An Wu, Joseph F Foss, Chun-Su Yuan. Determination of methylnaltrexone in clinical samples by solid-phase extraction and high-performance liquid chromatography for a pharmacokinetics study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Nov; 780(2):251-9. doi:
10.1016/s1570-0232(02)00527-5. [PMID: 12401350] - J F Foss. A review of the potential role of methylnaltrexone in opioid bowel dysfunction.
American journal of surgery.
2001 Nov; 182(5A Suppl):19S-26S. doi:
10.1016/s0002-9610(01)00783-8. [PMID: 11755893] - D B Murph, H El Behiery, V W Chan, J F Foss. Pharmacokinetic profile of epidurally administered methylnaltrexone, a novel peripheral opioid antagonist in a rabbit model.
British journal of anaesthesia.
2001 Jan; 86(1):120-2. doi:
10.1093/bja/86.1.120. [PMID: 11575386] - C S Yuan, J F Foss, M O'Connor, T Karrison, J Osinski, M F Roizen, J Moss. Effects of enteric-coated methylnaltrexone in preventing opioid-induced delay in oral-cecal transit time.
Clinical pharmacology and therapeutics.
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The Journal of pharmacology and experimental therapeutics.
1999 Feb; 288(2):502-8. doi:
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Drug and alcohol dependence.
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Anesthesiology.
1997 Oct; 87(4):765-70. doi:
10.1097/00000542-199710000-00008. [PMID: 9357876] - C S Yuan, J F Foss, J Osinski, A Toledano, M F Roizen, J Moss. The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time.
Clinical pharmacology and therapeutics.
1997 Apr; 61(4):467-75. doi:
10.1016/s0009-9236(97)90197-1. [PMID: 9129564] - J F Foss, M F O'Connor, C S Yuan, M Murphy, J Moss, M F Roizen. Safety and tolerance of methylnaltrexone in healthy humans: a randomized, placebo-controlled, intravenous, ascending-dose, pharmacokinetic study.
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