Isavuconazonium (BioDeep_00000837707)
代谢物信息卡片
Isavuconazonium
化学式: C35H35F2N8O5S+ (717.2419064)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=[N+](C=N3)C(C)OC(=O)N(C)C4=C(C=CC=N4)COC(=O)CNC)(C5=C(C=CC(=C5)F)F)O
InChI: InChI=1S/C35H35F2N8O5S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3/q+1/t22-,23?,35+/m0/s1
描述信息
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:85978
- KEGGdrug: D10644
- PubChem: 6918606
- DrugBank: DB06636
- ChEMBL: CHEMBL1183349
- CAS: 742049-41-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Brooke Rathie, Bart Theelen, Martin Laurence, Rebecca S Shapiro. Antimicrobial Susceptibility Testing for Three Malassezia Species.
Microbiology spectrum.
2023 08; 11(4):e0507622. doi:
10.1128/spectrum.05076-22. [PMID: 37310217] - Joseph P Lynch, George G Zhanel. Part 2: mucormycosis: focus on therapy.
Expert review of anti-infective therapy.
2023 Jun; ?(?):1-12. doi:
10.1080/14787210.2023.2224564. [PMID: 37300820] - Rajeev Soman, Sourabh Chakraborty, Geethu Joe. Posaconazole or isavuconazole as sole or predominant antifungal therapy for COVID-19-associated mucormycosis. A retrospective observational case series.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 Jul; 120(?):177-178. doi:
10.1016/j.ijid.2022.04.009. [PMID: 35405351] - Rainer Höhl, Ralph Bertram, Martina Kinzig, Golo-Sung Haarmeyer, Matthias Baumgärtel, Arnim Geise, Dorothea Muschner, Doris Prosch, Mira Reger, Hans-Theodor Naumann, Joachim H Ficker, Jens Kubitz, Joerg Steinmann, Fritz Sörgel. Isavuconazole therapeutic drug monitoring in critically ill ICU patients: A monocentric retrospective analysis.
Mycoses.
2022 Jul; 65(7):747-752. doi:
10.1111/myc.13469. [PMID: 35535740] - Shinichiro Shirae, Atsushi Ose, Yuji Kumagai. Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Isavuconazonium Sulfate in Healthy Adult Japanese Subjects.
Clinical pharmacology in drug development.
2022 06; 11(6):744-753. doi:
10.1002/cpdd.1079. [PMID: 35191210] - Thomas D Dieringer, Joanna M Schaenman, Matthew R Davis. Enteral feeding tube administration with therapeutic drug monitoring of crushed posaconazole tablets and opened isavuconazonium sulfate capsules.
The Journal of antimicrobial chemotherapy.
2022 04; 77(5):1417-1423. doi:
10.1093/jac/dkac035. [PMID: 35174391] - Geetha Sivasubramanian, Pranatharthi H Chandrasekar. Efficacy and safety of Isavuconazole for the treatment of invasive Aspergillus infection - an update of the literature.
Expert opinion on pharmacotherapy.
2022 Apr; 23(5):543-549. doi:
10.1080/14656566.2022.2032645. [PMID: 35099351] - Anna Lango-Maziarz, Magdalena Kołaczkowska, Piotr Siondalski, Maciej Duda, Michał Dubowik, Romuald Lango. Colon mucormycosis with renal spread resistant to lipid complex amphotericin and isavuconazole treatment in a heart transplant recipient.
Polish archives of internal medicine.
2022 01; 132(1):. doi:
10.20452/pamw.16156. [PMID: 34851070] - Max Melchers, Barbara Festen, Bianca M den Dekker, Eline R M Mooren, Annelien L van Binsbergen, Sjoerd H W van Bree, Moniek Heusinkveld, Roel Schellaars, Jochem B Buil, Paul E Verweij, Arthur R H van Zanten. A 67-Year-Old Male Patient With COVID-19 With Worsening Respiratory Function and Acute Kidney Failure.
Chest.
2022 01; 161(1):e5-e11. doi:
10.1016/j.chest.2021.08.045. [PMID: 35000717] - Ilona Kronig, Stavroula Masouridi-Levrat, Yves Chalandon, Emmanouil Glampedakis, Nathalie Vernaz, Christian Van Delden, Dionysios Neofytos. Clinical Considerations of Isavuconazole Administration in High-Risk Hematological Patients: A Single-Center 5-Year Experience.
Mycopathologia.
2021 Dec; 186(6):775-788. doi:
10.1007/s11046-021-00583-9. [PMID: 34432216] - Fruzsina Nagy, Zoltán Tóth, Fanni Nyikos, Lajos Forgács, Ágnes Jakab, Andrew M Borman, László Majoros, Renátó Kovács. In vitro and in vivo interaction of caspofungin with isavuconazole against Candida auris planktonic cells and biofilms.
Medical mycology.
2021 Oct; 59(10):1015-1023. doi:
10.1093/mmy/myab032. [PMID: 34021571] - Ahmed Gamal, Lisa Long, Janet Herrada, Jalal Aram, Thomas S McCormick, Mahmoud A Ghannoum. Efficacy of Voriconazole, Isavuconazole, Fluconazole, and Anidulafungin in the Treatment of Emerging Candida auris Using an Immunocompromised Murine Model of Disseminated Candidiasis.
Antimicrobial agents and chemotherapy.
2021 08; 65(9):e0054921. doi:
10.1128/aac.00549-21. [PMID: 34228541] - Amit Desai, Melanie Helmick, Nakyo Heo, Selina Moy, Stephen Stanhope, Ronald Goldwater, Nancy Martin. Pharmacokinetics and Bioequivalence of Isavuconazole Administered as Isavuconazonium Sulfate Intravenous Solution via Nasogastric Tube or Orally in Healthy Subjects.
Antimicrobial agents and chemotherapy.
2021 08; 65(9):e0044221. doi:
10.1128/aac.00442-21. [PMID: 34181478] - Maria Soledad Cuetara, Juan José Jusdado Ruiz-Capillas, Maria Pilar Nuñez-Valentin, Elena Rodríguez Garcia, Elena Garcia-Benayas, Ricardo Rojo-Amigo, Jose Carlos Rodriguez-Gallego, Ferry Hagen, María Francisca Colom. Successful Isavuconazole Salvage Therapy for a Cryptococcus deuterogattii (AFLP6/VGII) Disseminated Infection in a European Immunocompetent Patient.
Mycopathologia.
2021 Aug; 186(4):507-518. doi:
10.1007/s11046-021-00566-w. [PMID: 34115285] - Antonio C Arrieta, Michael Neely, J Christopher Day, Susan R Rheingold, Paul K Sue, William J Muller, Lara A Danziger-Isakov, Julie Chu, Inci Yildirim, Grace A McComsey, Haydar A Frangoul, Tempe K Chen, Victoria A Statler, William J Steinbach, Dwight E Yin, Kamal Hamed, Mark E Jones, Christopher Lademacher, Amit Desai, Kelley Micklus, Desiree Leiva Phillips, Laura L Kovanda, Thomas J Walsh. Safety, Tolerability, and Population Pharmacokinetics of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients.
Antimicrobial agents and chemotherapy.
2021 07; 65(8):e0029021. doi:
10.1128/aac.00290-21. [PMID: 34031051] - Philipp Koehler, Matteo Bassetti, Arunaloke Chakrabarti, Sharon C A Chen, Arnaldo Lopes Colombo, Martin Hoenigl, Nikolay Klimko, Cornelia Lass-Flörl, Rita O Oladele, Donald C Vinh, Li-Ping Zhu, Boris Böll, Roger Brüggemann, Jean-Pierre Gangneux, John R Perfect, Thomas F Patterson, Thorsten Persigehl, Jacques F Meis, Luis Ostrosky-Zeichner, P Lewis White, Paul E Verweij, Oliver A Cornely. Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance.
The Lancet. Infectious diseases.
2021 06; 21(6):e149-e162. doi:
10.1016/s1473-3099(20)30847-1. [PMID: 33333012] - Laura L Kovanda, Gabriele Sass, Marife Martinez, Karl V Clemons, Hasan Nazik, Therese M Kitt, Nathan Wiederhold, William W Hope, David A Stevens. Efficacy and Associated Drug Exposures of Isavuconazole and Fluconazole in an Experimental Model of Coccidioidomycosis.
Antimicrobial agents and chemotherapy.
2021 05; 65(6):. doi:
10.1128/aac.02344-20. [PMID: 33782009] - Jean Terrier, Marie-Céline Zanella, Stavroula Masouridi-Levrat, Ilona Kronig, Yves Chalandon, Nathalie Vernaz, Christian Van Delden, Genovefa Papanicolaou, Dionysios Neofytos. Clinical and Pharmacological Considerations for Concomitant Administration of Posaconazole and Isavuconazole with Letermovir.
Antimicrobial agents and chemotherapy.
2021 05; 65(6):. doi:
10.1128/aac.00274-21. [PMID: 33782007] - Christine A Vu, Meenakshi M Rana, Samantha E Jacobs, Patricia Saunders-Hao. Isavuconazole for the prophylaxis and treatment of invasive fungal disease: A single-center experience.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Apr; 23(2):e13469. doi:
10.1111/tid.13469. [PMID: 32946658] - Hernando Trujillo, Mario Fernández-Ruiz, Eduardo Gutiérrez, Ángel Sevillano, Fernando Caravaca-Fontán, Enrique Morales, Francisco López-Medrano, José María Aguado, Manuel Praga, Amado Andrés. Invasive pulmonary aspergillosis associated with COVID-19 in a kidney transplant recipient.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Apr; 23(2):e13501. doi:
10.1111/tid.13501. [PMID: 33185971] - Justin Spivey, Rebekah Wrenn, Beiyu Liu, Eileen Maziarz, Bridgette Kram. Characterization of Isavuconazole serum concentrations after enteral feeding tube administration in a hospitalized cohort: A case series.
Journal of clinical pharmacy and therapeutics.
2021 Apr; 46(2):528-531. doi:
10.1111/jcpt.13317. [PMID: 33247433] - Ikechukwu Achilonu, Emmanuel Amarachi Iwuchukwu, Okechinyere Juliet Achilonu, Manuel Antonio Fernandes, Yasien Sayed. Targeting the SARS-CoV-2 main protease using FDA-approved Isavuconazonium, a P2-P3 α-ketoamide derivative and Pentagastrin: An in-silico drug discovery approach.
Journal of molecular graphics & modelling.
2020 12; 101(?):107730. doi:
10.1016/j.jmgm.2020.107730. [PMID: 32920239] - Andrew M Borman, Jessica M Hughes, Debra Oliver, Mark Fraser, Julie Sunderland, Alan R Noel, Elizabeth M Johnson. Lessons from isavuconazole therapeutic drug monitoring at a United Kingdom Reference Center.
Medical mycology.
2020 Oct; 58(7):996-999. doi:
10.1093/mmy/myaa022. [PMID: 32396168] - E Stavropoulou, A T Coste, C Beigelman-Aubry, I Letovanec, O Spertini, A Lovis, T Krueger, R Burger, P Y Bochud, F Lamoth. Conidiobolus pachyzygosporus invasive pulmonary infection in a patient with acute myeloid leukemia: case report and review of the literature.
BMC infectious diseases.
2020 Jul; 20(1):527. doi:
10.1186/s12879-020-05218-w. [PMID: 32698804] - Davide Lazzarotto, Gabriele Facchin, Anna Candoni, Renato Fanin. 18F-FDG Positron Emission Tomography (PET) Scan as a Useful Tool to Assess Response to Antimycotic Therapy in Disseminated Invasive Mycosis in Acute Myeloid Leukemia.
Mycopathologia.
2020 06; 185(3):597-598. doi:
10.1007/s11046-020-00441-0. [PMID: 32266558] - Philipp Koehler, Oliver A Cornely, Bernd W Böttiger, Fabian Dusse, Dennis A Eichenauer, Frieder Fuchs, Michael Hallek, Norma Jung, Florian Klein, Thorsten Persigehl, Jan Rybniker, Matthias Kochanek, Boris Böll, Alexander Shimabukuro-Vornhagen. COVID-19 associated pulmonary aspergillosis.
Mycoses.
2020 Jun; 63(6):528-534. doi:
10.1111/myc.13096. [PMID: 32339350] - Vidmantas Petraitis, Ruta Petraitiene, Aspasia Katragkou, Bo Bo Win Maung, Ethan Naing, Povilas Kavaliauskas, Stephen Barat, Katyna Borroto-Esoda, Nkechi Azie, David Angulo, Thomas J Walsh. Combination Therapy with Ibrexafungerp (Formerly SCY-078), a First-in-Class Triterpenoid Inhibitor of (1→3)-β-d-Glucan Synthesis, and Isavuconazole for Treatment of Experimental Invasive Pulmonary Aspergillosis.
Antimicrobial agents and chemotherapy.
2020 05; 64(6):. doi:
10.1128/aac.02429-19. [PMID: 32179521] - Théo Willeman, Julia Tonini, Cécile Garnaud, Sébastien Bailly, Peggy Gandia, Françoise Stanke-Labesque, Danièle Maubon, Elodie Gautier-Veyret. Refining the therapeutic range of posaconazole and isavuconazole for efficient therapeutic drug monitoring using a bioassay approach.
Fundamental & clinical pharmacology.
2020 Apr; 34(2):279-287. doi:
10.1111/fcp.12507. [PMID: 31505058] - Xuemei Wu, Raman Venkataramanan, Ryan M Rivosecchi, Chenxiao Tang, Rachel V Marini, Ryan K Shields, Cornelius J Clancy, M Hong Nguyen. Population Pharmacokinetics of Intravenous Isavuconazole in Solid-Organ Transplant Recipients.
Antimicrobial agents and chemotherapy.
2020 01; 64(2):. doi:
10.1128/aac.01728-19. [PMID: 31767725] - Daniela Dalla Gasperina, Domenico Lombardi, Cristina Rovelli, Zaira Di Rosa, Valentina Lepera, Andreina Baj, Alice Nava, Gianluigi Lombardi, Paolo Antonio Grossi. Successful treatment with isavuconazole of subcutaneous phaeohyphomycosis in a kidney transplant recipient.
Transplant infectious disease : an official journal of the Transplantation Society.
2019 Dec; 21(6):e13197. doi:
10.1111/tid.13197. [PMID: 31617282] - Tobias Lahmer, Gonzalo Batres Baires, Markus Heilmaier, Roland M Schmid, Fritz Sörgel, Martina Kinzig, Wolfgang Huber, Ulrich Mayr, Sebastian Rasch. Influence of Sustained Low-Efficiency Dialysis Treatment on Isavuconazole Plasma Levels in Critically Ill Patients.
Antimicrobial agents and chemotherapy.
2019 11; 63(11):. doi:
10.1128/aac.01162-19. [PMID: 31427296] - Claire Rouzaud, Vincent Jullien, Anne Herbrecht, Bruno Palmier, Simona Lapusan, Marjolaine Morgand, Romain Guéry, Amélie Dureault, François Danion, Stéphanie Puget, Lauriane Goldwirt, Fanny Lanternier, Olivier Lortholary. Isavuconazole Diffusion in Infected Human Brain.
Antimicrobial agents and chemotherapy.
2019 10; 63(10):. doi:
10.1128/aac.02474-18. [PMID: 31405852] - Federico Pea, Robert Krause, Carsten Müller, Benjamin Hennart, Malcolm Richardson, Andreas Meinitzer, Martin H J Wiesen, Tatiana Wiktorowicz, Jochen Spickermann, Anne S Henriksen. Interlaboratory Analysis of Isavuconazole Plasma Concentration Assays Among European Laboratories.
Therapeutic drug monitoring.
2019 10; 41(5):657-664. doi:
10.1097/ftd.0000000000000632. [PMID: 31568234] - E Furfaro, A Signori, C Di Grazia, A Dominietto, A M Raiola, S Aquino, C Ghiggi, A Ghiso, R Ungaro, E Angelucci, C Viscoli, M Mikulska. Serial monitoring of isavuconazole blood levels during prolonged antifungal therapy.
The Journal of antimicrobial chemotherapy.
2019 08; 74(8):2341-2346. doi:
10.1093/jac/dkz188. [PMID: 31119272] - Karin Meinike Jørgensen, Karen Marie Thyssen Astvad, Rasmus Krøger Hare, Maiken Cavling Arendrup. EUCAST Susceptibility Testing of Isavuconazole: MIC Data for Contemporary Clinical Mold and Yeast Isolates.
Antimicrobial agents and chemotherapy.
2019 06; 63(6):. doi:
10.1128/aac.00073-19. [PMID: 30910898] - Amit V Desai, David Han, Donna L Kowalski, Christopher Lademacher, Helene Pearlman, Takao Yamazaki. No Dose Adjustment for Isavuconazole Based on Age or Sex.
Antimicrobial agents and chemotherapy.
2019 06; 63(6):. doi:
10.1128/aac.02629-18. [PMID: 30962330] - Leibin Shen, Jun Wang, Yongdong Yi, Chenmin Ye, Rongrong Wang, Guojun Xia, Chengyang Yu, Fuyang Tu, Jingxuan Xu, Zhiqiang Zheng. Inhibitory effect of isavuconazole, ketoconazole, and voriconazole on the pharmacokinetics of methadone in vivo and in vitro.
Drug testing and analysis.
2019 Apr; 11(4):595-600. doi:
10.1002/dta.2534. [PMID: 30370647] - Thomas Kaindl, David Andes, Marc Engelhardt, Mikael Saulay, Patrice Larger, Andreas H Groll. Variability and exposure-response relationships of isavuconazole plasma concentrations in the Phase 3 SECURE trial of patients with invasive mould diseases.
The Journal of antimicrobial chemotherapy.
2019 03; 74(3):761-767. doi:
10.1093/jac/dky463. [PMID: 30476108] - Van Kieu, Kristi Jhangiani, Sanjeet Dadwal, Ryotaro Nakamura, Doreen Pon. Effect of isavuconazole on tacrolimus and sirolimus serum concentrations in allogeneic hematopoietic stem cell transplant patients: A drug-drug interaction study.
Transplant infectious disease : an official journal of the Transplantation Society.
2019 Feb; 21(1):e13007. doi:
10.1111/tid.13007. [PMID: 30295407] - Gillen Oarbeascoa, Nieves Dorado, Rebeca Bailén, David Serrano, Pascual Balsalobre, Virginia Pradillo, Jesus Guinea, Belen Padilla, Milagros Sancho, Marina Machado, Ismael Buño, Javier Anguita, Jose Luis Diez-Martin, Mi Kwon. Successful Treatment of Severe Aspergillosis with Isavuconazole Therapy after Allogeneic Stem Cell Transplantation.
Chemotherapy.
2019; 64(2):57-61. doi:
10.1159/000502279. [PMID: 31484176] - Xuemei Wu, Cornelius J Clancy, Ryan M Rivosecchi, Wenchen Zhao, Ryan K Shields, Rachel V Marini, Raman Venkataramanan, M Hong Nguyen. Pharmacokinetics of Intravenous Isavuconazole in Solid-Organ Transplant Recipients.
Antimicrobial agents and chemotherapy.
2018 12; 62(12):. doi:
10.1128/aac.01643-18. [PMID: 30275091] - Giulio Nannetti, Silvana Pagni, Giorgio Palù, Arianna Loregian. A sensitive and validated HPLC-UV method for the quantitative determination of the new antifungal drug isavuconazole in human plasma.
Biomedical chromatography : BMC.
2018 Nov; 32(11):e4333. doi:
10.1002/bmc.4333. [PMID: 29978912] - José Ramón Azanza Perea, Belén Sádaba Díaz de Rada. [Pharmacological profile of isavuconazole].
Revista iberoamericana de micologia.
2018 Oct; 35(4):186-191. doi:
10.1016/j.riam.2018.04.003. [PMID: 30477963] - José Tiago Silva, Julián Torre-Cisneros, José María Aguado. [Invasive aspergillosis in solid organ transplantation].
Revista iberoamericana de micologia.
2018 Oct; 35(4):206-209. doi:
10.1016/j.riam.2018.05.002. [PMID: 30467000] - Julian Hösl, André Gessner, Nahed El-Najjar. Liquid chromatography-tandem mass spectrometry for the quantification of moxifloxacin, ciprofloxacin, daptomycin, caspofungin, and isavuconazole in human plasma.
Journal of pharmaceutical and biomedical analysis.
2018 Aug; 157(?):92-99. doi:
10.1016/j.jpba.2018.05.015. [PMID: 29777985] - Silke C Mueller, Ilona Karasch, Johannes Lakner, Rainer Wacke. Validation of an Isavuconazole High-Performance Liquid Chromatography Assay in Plasma for Routine Therapeutic Drug Monitoring Applications.
Therapeutic drug monitoring.
2018 08; 40(4):503-506. doi:
10.1097/ftd.0000000000000524. [PMID: 29994987] - Elena Arsiè, Stefania Piconi, Massimo Iavarone, Valeria Cozzi, Pietro Lampertico, Dario Cattaneo. High isavuconazole plasma levels in a patient with possible invasive pulmonary aspergillosis and cirrhosis.
European journal of clinical pharmacology.
2018 Aug; 74(8):1089-1090. doi:
10.1007/s00228-018-2462-0. [PMID: 29666903] - Valeria Cozzi, Sara Baldelli, Simone Castoldi, Emilio Clementi, Dario Cattaneo. Development and Validation of a Chromatographic Ultraviolet Method for the Quantification of Isavuconazole in Human Plasma Samples.
Therapeutic drug monitoring.
2018 08; 40(4):512-514. doi:
10.1097/ftd.0000000000000523. [PMID: 29750740] - David Andes, Laura Kovanda, A Desai, Therese Kitt, M Zhao, Thomas J Walsh. Isavuconazole Concentration in Real-World Practice: Consistency with Results from Clinical Trials.
Antimicrobial agents and chemotherapy.
2018 07; 62(7):. doi:
10.1128/aac.00585-18. [PMID: 29735569] - A J Ullmann, J M Aguado, S Arikan-Akdagli, D W Denning, A H Groll, K Lagrou, C Lass-Flörl, R E Lewis, P Munoz, P E Verweij, A Warris, F Ader, M Akova, M C Arendrup, R A Barnes, C Beigelman-Aubry, S Blot, E Bouza, R J M Brüggemann, D Buchheidt, J Cadranel, E Castagnola, A Chakrabarti, M Cuenca-Estrella, G Dimopoulos, J Fortun, J-P Gangneux, J Garbino, W J Heinz, R Herbrecht, C P Heussel, C C Kibbler, N Klimko, B J Kullberg, C Lange, T Lehrnbecher, J Löffler, O Lortholary, J Maertens, O Marchetti, J F Meis, L Pagano, P Ribaud, M Richardson, E Roilides, M Ruhnke, M Sanguinetti, D C Sheppard, J Sinkó, A Skiada, M J G T Vehreschild, C Viscoli, O A Cornely. Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2018 May; 24 Suppl 1(?):e1-e38. doi:
10.1016/j.cmi.2018.01.002. [PMID: 29544767] - Andrew Smith, Justin Dowis, Deborah French. Quantification of Serum Voriconazole, Isavuconazole, and Posaconazole by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS).
Current protocols in toxicology.
2018 05; 76(1):e47. doi:
10.1002/cptx.47. [PMID: 30040225] - Robert Townsend, Kota Kato, Christine Hale, Donna Kowalski, Christopher Lademacher, Takao Yamazaki, Shahzad Akhtar, Amit Desai. Two Phase 1, Open-Label, Mass Balance Studies to Determine the Pharmacokinetics of 14 C-Labeled Isavuconazonium Sulfate in Healthy Male Volunteers.
Clinical pharmacology in drug development.
2018 02; 7(2):207-216. doi:
10.1002/cpdd.376. [PMID: 28750160] - Francesco Marchesi, Corrado Girmenia, Bianca Maria Goffredo, Emanuela Salvatorelli, Atelda Romano, Andrea Mengarelli, Giorgio Minotti, Pierantonio Menna. Isavuconazole: Case Report and Pharmacokinetic Considerations.
Chemotherapy.
2018; 63(5):253-256. doi:
10.1159/000494329. [PMID: 30458443] - Anjan Debnath, Claudia M Calvet, Gareth Jennings, Wenxu Zhou, Alexander Aksenov, Madeline R Luth, Ruben Abagyan, W David Nes, James H McKerrow, Larissa M Podust. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).
PLoS neglected tropical diseases.
2017 12; 11(12):e0006104. doi:
10.1371/journal.pntd.0006104. [PMID: 29284029] - Amit V Desai, Laura L Kovanda, William W Hope, David Andes, Johan W Mouton, Donna L Kowalski, Robert W Townsend, Salim Mujais, Peter L Bonate. Exposure-Response Relationships for Isavuconazole in Patients with Invasive Aspergillosis and Other Filamentous Fungi.
Antimicrobial agents and chemotherapy.
2017 12; 61(12):. doi:
10.1128/aac.01034-17. [PMID: 28923872] - Anne-Hortense Schmitt-Hoffmann, Kota Kato, Robert Townsend, Michael J Potchoiba, William W Hope, David Andes, Jochen Spickermann, Marlowe J Schneidkraut. Tissue Distribution and Elimination of Isavuconazole following Single and Repeat Oral-Dose Administration of Isavuconazonium Sulfate to Rats.
Antimicrobial agents and chemotherapy.
2017 12; 61(12):. doi:
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Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2017 Nov; 23(11):882-887. doi:
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Journal of pharmaceutical and biomedical analysis.
2017 Oct; 145(?):718-724. doi:
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Therapeutic drug monitoring.
2017 10; 39(5):505-513. doi:
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Antimicrobial agents and chemotherapy.
2017 09; 61(9):. doi:
10.1128/aac.00305-17. [PMID: 28696236] - Ryan M Rivosecchi, Cornelius J Clancy, Ryan K Shields, Christopher R Ensor, Michael A Shullo, Bonnie A Falcione, Raman Venkataramanan, M Hong Nguyen. Effects of Isavuconazole on the Plasma Concentrations of Tacrolimus among Solid-Organ Transplant Patients.
Antimicrobial agents and chemotherapy.
2017 09; 61(9):. doi:
10.1128/aac.00970-17. [PMID: 28674051] - Robert W Townsend, Shahzad Akhtar, Harry Alcorn, Jolene K Berg, Donna L Kowalski, Salim Mujais, Amit V Desai. Phase I trial to investigate the effect of renal impairment on isavuconazole pharmacokinetics.
European journal of clinical pharmacology.
2017 Jun; 73(6):669-678. doi:
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Antimicrobial agents and chemotherapy.
2017 06; 61(6):. doi:
10.1128/aac.00101-17. [PMID: 28289034] - Laura L Kovanda, Ruwanthi Kolamunnage-Dona, Michael Neely, Johan Maertens, Misun Lee, William W Hope. Pharmacodynamics of Isavuconazole for Invasive Mold Disease: Role of Galactomannan for Real-Time Monitoring of Therapeutic Response.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2017 Jun; 64(11):1557-1563. doi:
10.1093/cid/cix198. [PMID: 28472247] - J Keirns, A Desai, D Kowalski, C Lademacher, S Mujais, B Parker, M J Schneidkraut, R Townsend, T Wojtkowski, T Yamazaki, M Yen, P R Kowey. QT Interval Shortening With Isavuconazole: In Vitro and In Vivo Effects on Cardiac Repolarization.
Clinical pharmacology and therapeutics.
2017 Jun; 101(6):782-790. doi:
10.1002/cpt.620. [PMID: 28074556] - Fei Xie, Tingjunhong Ni, Jing Zhao, Lei Pang, Ran Li, Zhan Cai, Zichao Ding, Ting Wang, Shichong Yu, Yongsheng Jin, Dazhi Zhang, Yuanying Jiang. Design, synthesis, and in vitro evaluation of novel antifungal triazoles.
Bioorganic & medicinal chemistry letters.
2017 05; 27(10):2171-2173. doi:
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The Journal of antimicrobial chemotherapy.
2017 03; 72(suppl_1):i12-i18. doi:
10.1093/jac/dkx029. [PMID: 28355463] - Balthazar Toussaint, Fanny Lanternier, Christian Woloch, Denis Fournier, Manon Launay, Eliane Billaud, Eric Dannaoui, Olivier Lortholary, Vincent Jullien. An ultra performance liquid chromatography-tandem mass spectrometry method for the therapeutic drug monitoring of isavuconazole and seven other antifungal compounds in plasma samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Mar; 1046(?):26-33. doi:
10.1016/j.jchromb.2017.01.036. [PMID: 28131025] - Amit Desai, Takao Yamazaki, Albert J Dietz, Donna Kowalski, Christopher Lademacher, Helene Pearlman, Shahzad Akhtar, Robert Townsend. Pharmacokinetic and Pharmacodynamic Evaluation of the Drug-Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects.
Clinical pharmacology in drug development.
2017 Jan; 6(1):86-92. doi:
10.1002/cpdd.283. [PMID: 27278712] - Maiken Cavling Arendrup, Paul Verweij, Henrik Vedel Nielsen. Evaluation of MIC Strip Isavuconazole Test for Susceptibility Testing of Wild-Type and Non-Wild-Type Aspergillus fumigatus Isolates.
Antimicrobial agents and chemotherapy.
2017 01; 61(1):. doi:
10.1128/aac.01659-16. [PMID: 27799223] - Wonhee So, Liz Kim, Abrar K Thabit, David P Nicolau, Joseph L Kuti. Physical compatibility of isavuconazonium sulfate with select i.v. drugs during simulated Y-site administration.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2017 Jan; 74(1):e55-e63. doi:
10.2146/ajhp150733. [PMID: 28007722] - Takao Yamazaki, Amit Desai, Ronald Goldwater, David Han, Kenneth C Lasseter, Corrie Howieson, Shahzad Akhtar, Donna Kowalski, Christopher Lademacher, Diane Rammelsberg, Robert Townsend. Pharmacokinetic Interactions Between Isavuconazole and the Drug Transporter Substrates Atorvastatin, Digoxin, Metformin, and Methotrexate in Healthy Subjects.
Clinical pharmacology in drug development.
2017 Jan; 6(1):66-75. doi:
10.1002/cpdd.280. [PMID: 27273004] - Amit Desai, Laura Kovanda, Donna Kowalski, Qiaoyang Lu, Robert Townsend, Peter L Bonate. Population Pharmacokinetics of Isavuconazole from Phase 1 and Phase 3 (SECURE) Trials in Adults and Target Attainment in Patients with Invasive Infections Due to Aspergillus and Other Filamentous Fungi.
Antimicrobial agents and chemotherapy.
2016 09; 60(9):5483-91. doi:
10.1128/aac.02819-15. [PMID: 27381396] - Nathan P Wiederhold, Laura Kovanda, Laura K Najvar, Rosie Bocanegra, Marcos Olivo, William R Kirkpatrick, Thomas F Patterson. Isavuconazole Is Effective for the Treatment of Experimental Cryptococcal Meningitis.
Antimicrobial agents and chemotherapy.
2016 09; 60(9):5600-3. doi:
10.1128/aac.00229-16. [PMID: 27324761] - Anne Schmitt-Hoffmann, Amit Desai, Donna Kowalski, Helene Pearlman, Takao Yamazaki, Robert Townsend. Isavuconazole absorption following oral administration in healthy subjects is comparable to intravenous dosing, and is not affected by food, or drugs that alter stomach pH.
International journal of clinical pharmacology and therapeutics.
2016 Aug; 54(8):572-80. doi:
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Current opinion in infectious diseases.
2016 08; 29(4):340-5. doi:
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The Journal of antimicrobial chemotherapy.
2016 07; 71(7):1885-91. doi:
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Antimicrobial agents and chemotherapy.
2016 05; 60(5):2718-26. doi:
10.1128/aac.02665-15. [PMID: 26883703] - Amit Desai, Anne-Hortense Schmitt-Hoffmann, Salim Mujais, Robert Townsend. Population Pharmacokinetics of Isavuconazole in Subjects with Mild or Moderate Hepatic Impairment.
Antimicrobial agents and chemotherapy.
2016 05; 60(5):3025-31. doi:
10.1128/aac.02942-15. [PMID: 26953193] - Maiken Cavling Arendrup, Rasmus Hare Jensen, Joseph Meletiadis. In Vitro Activity of Isavuconazole and Comparators against Clinical Isolates of the Mucorales Order.
Antimicrobial agents and chemotherapy.
2015 12; 59(12):7735-42. doi:
10.1128/aac.01919-15. [PMID: 26438494] - François Danion, Claire Aguilar, Emilie Catherinot, Alexandre Alanio, Susan DeWolf, Olivier Lortholary, Fanny Lanternier. Mucormycosis: New Developments into a Persistently Devastating Infection.
Seminars in respiratory and critical care medicine.
2015 Oct; 36(5):692-705. doi:
10.1055/s-0035-1562896. [PMID: 26398536] - Oliver A Cornely, Angelika Böhme, Anne Schmitt-Hoffmann, Andrew J Ullmann. Safety and pharmacokinetics of isavuconazole as antifungal prophylaxis in acute myeloid leukemia patients with neutropenia: results of a phase 2, dose escalation study.
Antimicrobial agents and chemotherapy.
2015 Apr; 59(4):2078-85. doi:
10.1128/aac.04569-14. [PMID: 25624327] - Maiken Cavling Arendrup, Susan Howard, Cornelia Lass-Flörl, Johan W Mouton, Joseph Meletiadis, Manuel Cuenca-Estrella. EUCAST testing of Isavuconazole susceptibility in Aspergillus: comparison of results for Inoculum standardization using Conidium counting versus optical density.
Antimicrobial agents and chemotherapy.
2014 Nov; 58(11):6432-6. doi:
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Infection.
2014 Apr; 42(2):429-32. doi:
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Antimicrobial agents and chemotherapy.
2013 Oct; 57(10):4841-7. doi:
10.1128/aac.00850-13. [PMID: 23877683] - Sheng-zheng Wang, Chun-quan Sheng, Wan-nian Zhang. [Recent advances in the study of new antifungal lead compounds].
Yao xue xue bao = Acta pharmaceutica Sinica.
2010 Aug; 45(8):966-75. doi:
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Antimicrobial agents and chemotherapy.
2009 Nov; 53(11):4885-90. doi:
10.1128/aac.00319-09. [PMID: 19667286] - Peter A Warn, Andrew Sharp, Arvind Parmar, Jayesh Majithiya, David W Denning, William W Hope. Pharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: mathematical modeling, importance of tissue concentrations, and impact of immune status on antifungal effect.
Antimicrobial agents and chemotherapy.
2009 Aug; 53(8):3453-61. doi:
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The Journal of antimicrobial chemotherapy.
2009 Jan; 63(1):161-6. doi:
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Antimicrobial agents and chemotherapy.
2006 Jan; 50(1):279-85. doi:
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Antimicrobial agents and chemotherapy.
2006 Jan; 50(1):286-93. doi:
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