Betamethasone phosphate (BioDeep_00000837706)
代谢物信息卡片
Betamethasone phosphate
化学式: C22H30FO8P (472.1662242)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)(O)O)O)C)O)F)C
InChI: InChI=1S/C22H30FO8P/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30)/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:68603
- PubChem: 107782
- DrugBank: DB14669
- ChEMBL: CHEMBL1201207
- CAS: 360-63-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tsukasa Takahashi, Erin L Fee, Yuki Takahashi, Masatoshi Saito, Nobuo Yaegashi, Haruo Usuda, Lucy Furfaro, Sean Carter, Augusto F Schmidt, John P Newnham, Alan H Jobe, Matthew W Kemp. Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birthweights when administered to pregnant sheep in combination with betamethasone acetate.
American journal of obstetrics and gynecology.
2022 04; 226(4):564.e1-564.e14. doi:
10.1016/j.ajog.2021.10.001. [PMID: 34626553] - Tsukasa Takahashi, Masatoshi Saito, Augusto F Schmidt, Haruo Usuda, Yuki Takahashi, Shimpei Watanabe, Takushi Hanita, Shinichi Sato, Yusaku Kumagai, Shota Koshinami, Hideyuki Ikeda, Sean Carter, Michael Clarke, Erin L Fee, Nobuo Yaegashi, John P Newnham, Alan H Jobe, Matthew W Kemp. Variability in the efficacy of a standardized antenatal steroid treatment was independent of maternal or fetal plasma drug levels: evidence from a sheep model of pregnancy.
American journal of obstetrics and gynecology.
2020 12; 223(6):921.e1-921.e10. doi:
10.1016/j.ajog.2020.05.032. [PMID: 32445634] - Alan H Jobe, Mark A Milad, Thomas Peppard, William J Jusko. Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India.
Clinical and translational science.
2020 03; 13(2):391-399. doi:
10.1111/cts.12724. [PMID: 31808984] - Matthew W Kemp, Masatoshi Saito, Augusto F Schmidt, Haruo Usuda, Shimpei Watanabe, Shinichi Sato, Takushi Hanita, Yusaku Kumagai, Tsukasa Takahashi, Gabrielle C Musk, Lucy Furfaro, Lisa Stinson, Erin L Fee, Peter J Eddershaw, Matthew S Payne, Kiara Smallwood, James Bridges, John P Newnham, Alan H Jobe. The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation.
American journal of obstetrics and gynecology.
2020 02; 222(2):183.e1-183.e9. doi:
10.1016/j.ajog.2019.08.046. [PMID: 31494126] - Augusto F Schmidt, Matthew W Kemp, Mark Milad, Lisa A Miller, James P Bridges, Michael W Clarke, Paranthaman S Kannan, Alan H Jobe. Oral dosing for antenatal corticosteroids in the Rhesus macaque.
PloS one.
2019; 14(9):e0222817. doi:
10.1371/journal.pone.0222817. [PMID: 31536601] - Matthew W Kemp, Masatoshi Saito, Haruo Usuda, Shimpei Watanabe, Shinichi Sato, Takushi Hanita, Yusaku Kumagai, Timothy J Molloy, Michael Clarke, Peter J Eddershaw, Gabrielle C Musk, Augusto Schmidt, Demelza Ireland, Lucy Furfaro, Matthew S Payne, John P Newnham, Alan H Jobe. The efficacy of antenatal steroid therapy is dependent on the duration of low-concentration fetal exposure: evidence from a sheep model of pregnancy.
American journal of obstetrics and gynecology.
2018 09; 219(3):301.e1-301.e16. doi:
10.1016/j.ajog.2018.05.007. [PMID: 29758177] - Augusto F Schmidt, Matthew W Kemp, Judith Rittenschober-Böhm, Paranthaman S Kannan, Haruo Usuda, Masatoshi Saito, Lucy Furfaro, Shimpei Watanabe, Sarah Stock, Boris W Kramer, John P Newnham, Suhas G Kallapur, Alan H Jobe. Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep.
American journal of obstetrics and gynecology.
2018 01; 218(1):132.e1-132.e9. doi:
10.1016/j.ajog.2017.11.560. [PMID: 29138038] - Heather K Knych, Scott D Stanley, Linda M Harrison, Daniel S Mckemie. Pharmacokinetics of betamethasone in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses.
Drug testing and analysis.
2017 Sep; 9(9):1385-1391. doi:
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Pediatrics.
2017 Feb; 139(2):. doi:
10.1542/peds.2016-1233. [PMID: 28104732] - Matthew W Kemp, Masatoshi Saito, Haruo Usuda, Timothy J Molloy, Yuichiro Miura, Shinichi Sato, Shimpei Watanabe, Michael Clarke, Michael Fossler, Augusto Scmidt, Suhas G Kallapur, Boris W Kramer, John P Newnham, Alan H Jobe. Maternofetal pharmacokinetics and fetal lung responses in chronically catheterized sheep receiving constant, low-dose infusions of betamethasone phosphate.
American journal of obstetrics and gynecology.
2016 Dec; 215(6):775.e1-775.e12. doi:
10.1016/j.ajog.2016.08.017. [PMID: 27555319] - M I Menendez, M A Phelps, A L Bertone. Pharmacokinetics of intra-articular betamethasone sodium phosphate and betamethasone acetate and endogenous hydrocortisone suppression in exercising horses.
Journal of veterinary pharmacology and therapeutics.
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Surgery today.
2015 Jan; 45(1):110-4. doi:
10.1007/s00595-013-0754-7. [PMID: 24132684] - George Habib, Suheil Artul, Mark Chernin, Geries Hakim, Adel Jabbour. The effect of intra-articular injection of betamethasone acetate/betamethasone sodium phosphate at the knee joint on the hypothalamic-pituitary-adrenal axis: a case-controlled study.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
2013 Oct; 61(7):1104-7. doi:
10.2310/jim.0b013e3182a67871. [PMID: 24013525] - Isam I Salem, Naji M Najib. Pharmacokinetics of betamethasone after single-dose intramuscular administration of betamethasone phosphate and betamethasone acetate to healthy subjects.
Clinical therapeutics.
2012 Jan; 34(1):214-20. doi:
10.1016/j.clinthera.2011.11.022. [PMID: 22154197] - S-C Liu, B-H Kang, J-C Lee, Y-S Lin, K-L Huang, D-W Liu, W-F Su, C-H Kao, Y-H Chu, H-C Chen, C-H Wang. Comparison of therapeutic results in sudden sensorineural hearing loss with/without additional hyperbaric oxygen therapy: a retrospective review of 465 audiologically controlled cases.
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery.
2011 Apr; 36(2):121-8. doi:
10.1111/j.1749-4486.2011.02303.x. [PMID: 21414179] - Tetsuya Tajika, Mitsunori Waki, Masakatsu Tsuzuki, Tetsuo Kida, Hideyuki Sakaki. Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2011 Feb; 27(1):29-34. doi:
10.1089/jop.2010.0106. [PMID: 21182429] - Chunhui He, Hongwei Fan, Jie Tan, Jianjun Zou, Yubing Zhu, Kun Yang, Qin Hu. Pharmacokinetics of betamethasone and betamethasone 17-monopropionate in Chinese healthy volunteers after intramuscular injection of betamethasone phosphate/betamethasone dipropionate.
Arzneimittel-Forschung.
2011; 61(7):417-20. doi:
10.1055/s-0031-1296220. [PMID: 21899210] - Tsutomu Ishihara, Tetsushi Kubota, Tesu Choi, Miyuki Takahashi, Eri Ayano, Hideko Kanazawa, Megumu Higaki. Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness.
International journal of pharmaceutics.
2009 Jun; 375(1-2):148-54. doi:
10.1016/j.ijpharm.2009.04.001. [PMID: 19481700] - George Habib, Ahmed Safia. The effect of intra-articular injection of betamethasone acetate/betamethasone sodium phosphate on blood glucose levels in controlled diabetic patients with symptomatic osteoarthritis of the knee.
Clinical rheumatology.
2009 Jan; 28(1):85-7. doi:
10.1007/s10067-008-1023-9. [PMID: 18853221] - Matthias Schwab, Turhan Coksaygan, Mahesh N Samtani, William J Jusko, Peter W Nathanielsz. Kinetics of betamethasone and fetal cardiovascular adverse effects in pregnant sheep after different doses.
Obstetrics and gynecology.
2006 Sep; 108(3 Pt 1):617-25. doi:
10.1097/01.aog.0000232815.80648.01. [PMID: 16946223] - Masayoshi Kobayashi, Yoshinori Imanishi, Masako Ishikawa, Kohei Nishida, Mitsuo Adachi, Maaya Oishi, Satoshi Nakamura, Hiroshi Sakaida, Yuichi Majima. [Safety and usefulness of the long-term intranasal topical treatment with steroids for olfactory dysfunction].
Nihon Jibiinkoka Gakkai kaiho.
2005 Oct; 108(10):986-95. doi:
10.3950/jibiinkoka.108.986. [PMID: 16285614] - Mahesh N Samtani, Matthias Lohle, Angela Grant, Peter W Nathanielsz, William J Jusko. Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Aug; 33(8):1124-30. doi:
10.1124/dmd.105.004309. [PMID: 15860658] - Masayuki Nara, Kan Sasamori, Sanae Shimura, Hiromasa Ogawa, Satsuki Ishigaki-Suzuki, Miyuki Nagaoka, Tsutomu Tamada, Masakazu Ichinose, Gen Tamura, Toshio Hattori. Long-term use of corticosteroid eye drops delays the spontaneous remission of pulmonary sarcoidosis.
The Tohoku journal of experimental medicine.
2004 Apr; 202(4):275-82. doi:
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Rheumatology (Oxford, England).
2004 Apr; 43(4):428-34. doi:
10.1093/rheumatology/keh073. [PMID: 15024132] - Mahesh N Samtani, Matthias Schwab, Peter W Nathanielsz, William J Jusko. Stabilization and HPLC analysis of betamethasone sodium phosphate in plasma.
Journal of pharmaceutical sciences.
2004 Mar; 93(3):726-32. doi:
10.1002/jps.10577. [PMID: 14762910] - Eijiro Horisawa, Tsuyoshi Hirota, Satoko Kawazoe, Jun Yamada, Hiromitsu Yamamoto, Hirofumi Takeuchi, Yoshiaki Kawashima. Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbit.
Pharmaceutical research.
2002 Apr; 19(4):403-10. doi:
10.1023/a:1015123024113. [PMID: 12033371] - Z Halpern, O Sold, M Baratz, F Konikoff, A Halak, T Gilat. A controlled trial of beclomethasone versus betamethasone enemas in distal ulcerative colitis.
Journal of clinical gastroenterology.
1991 Feb; 13(1):38-41. doi:
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British journal of clinical pharmacology.
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Acta endocrinologica.
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The Journal of international medical research.
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Clinical pharmacology and therapeutics.
1983 Mar; 33(3):343-50. doi:
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European journal of clinical pharmacology.
1983; 25(6):803-10. doi:
10.1007/bf00542524. [PMID: 6662178] - J J Kjer, J Hess. Serum estriol level during treatment with betamethasone in the last trimester of human pregnancy.
Acta obstetricia et gynecologica Scandinavica.
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Padiatrie und Padologie.
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