Lesogaberan (BioDeep_00000837688)
代谢物信息卡片
化学式: C3H8FNO2P+ (140.027667)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C[P+](=O)O)F)N
InChI: InChI=1S/C3H7FNO2P/c4-3(1-5)2-8(6)7/h3H,1-2,5H2/p+1/t3-/m1/s1
描述信息
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists
C78276 - Agent Affecting Digestive System or Metabolism
D005765 - Gastrointestinal Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ann Aurell Holmberg, Anja Ekdahl, Lars Weidolf. Systemic exposure to the metabolites of lesogaberan in humans and animals: a case study of metabolites in safety testing.
Drug metabolism and disposition: the biological fate of chemicals.
2014 Jun; 42(6):1016-21. doi:
10.1124/dmd.113.056614. [PMID: 24658456] - Kristina Dunér, Pernilla Bottner, Anna-Karin Norlén. Development of analytical methods for the quantification of metabolites of lesogaberan in a MIST investigation.
Biomedical chromatography : BMC.
2014 Mar; 28(3):362-8. doi:
10.1002/bmc.3029. [PMID: 24037996] - Anja Ekdahl, Ann Aurell-Holmberg, Neal Castagnoli. Identification of the metabolites of lesogaberan using linear trap quadrupole orbitrap mass spectrometry and hydrophilic interaction liquid chromatography.
Xenobiotica; the fate of foreign compounds in biological systems.
2013 May; 43(5):461-7. doi:
10.3109/00498254.2012.725486. [PMID: 23030741] - Bo Fransson, Debra G Silberg, Mohammad Niazi, Frank Miller, Magnus Ruth, Ann Aurell Holmberg. Effect of food on the bioavailability of lesogaberan given as an oral solution or as modified-release capsules in healthy male volunteers.
International journal of clinical pharmacology and therapeutics.
2012 Apr; 50(4):307-14. doi:
10.5414/cp201587. [PMID: 22456303] - Mohammad Niazi, Stanko Skrtic, Magnus Ruth, Ann A Holmberg. Pharmacokinetic profile of lesogaberan (AZD3355) in healthy subjects: a novel GABA(B)-receptor agonist reflux inhibitor.
Drugs in R&D.
2011; 11(1):77-83. doi:
10.2165/11590310-000000000-00000. [PMID: 21410297] - Mohammad Niazi, Debra G Silberg, Frank Miller, Magnus Ruth, Ann A Holmberg. Evaluation of the pharmacokinetic interaction between lesogaberan (AZD3355) and esomeprazole in healthy subjects.
Drugs in R&D.
2010; 10(4):243-51. doi:
10.2165/11588180-000000000-00000. [PMID: 21171670] - Anders Lehmann, Madeleine Antonsson, Ann Aurell Holmberg, L Ashley Blackshaw, Lena Brändén, Hans Bräuner-Osborne, Bolette Christiansen, John Dent, Thomas Elebring, Britt-Marie Jacobson, Jörgen Jensen, Jan P Mattsson, Karolina Nilsson, Simo S Oja, Amanda J Page, Pirjo Saransaari, Sverker von Unge. (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.
The Journal of pharmacology and experimental therapeutics.
2009 Nov; 331(2):504-12. doi:
10.1124/jpet.109.153593. [PMID: 19648470]