vamorolone (BioDeep_00000837686)
代谢物信息卡片
化学式: C22H28O4 (356.19874880000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3=CCC2(C1(C(=O)CO)O)C)C
InChI: InChI=1S/C22H28O4/c1-13-10-18-16-5-4-14-11-15(24)6-8-20(14,2)17(16)7-9-21(18,3)22(13,26)19(25)12-23/h6-8,11,13,16,18,23,26H,4-5,9-10,12H2,1-3H3/t13-,16-,18+,20+,21+,22+/m1/s1
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D11000
- PubChem: 3035000
- DrugBank: DB15114
- ChEMBL: CHEMBL2348780
- CAS: 13209-41-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Michael Ziemba, Molly Barkhouse, Kitipong Uaesoontrachoon, Mamta Giri, Yetrib Hathout, Utkarsh J Dang, Heather Gordish-Dressman, Kanneboyina Nagaraju, Eric P Hoffman. Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice.
PloS one.
2021; 16(2):e0246507. doi:
10.1371/journal.pone.0246507. [PMID: 33617542] - Xiaonan Li, Laurie S Conklin, John van den Anker, Eric P Hoffman, Paula R Clemens, William J Jusko. Exposure-Response Analysis of Vamorolone (VBP15) in Boys With Duchenne Muscular Dystrophy.
Journal of clinical pharmacology.
2020 10; 60(10):1385-1396. doi:
10.1002/jcph.1632. [PMID: 32434278] - Utkarsh J Dang, Michael Ziemba, Paula R Clemens, Yetrib Hathout, Laurie S Conklin, Eric P Hoffman. Serum biomarkers associated with baseline clinical severity in young steroid-naïve Duchenne muscular dystrophy boys.
Human molecular genetics.
2020 08; 29(15):2481-2495. doi:
10.1093/hmg/ddaa132. [PMID: 32592467] - Panteleimon D Mavroudis, John van den Anker, Laurie S Conklin, Jesse M Damsker, Eric P Hoffman, Kanneboyina Nagaraju, Paula R Clemens, William J Jusko. Population Pharmacokinetics of Vamorolone (VBP15) in Healthy Men and Boys With Duchenne Muscular Dystrophy.
Journal of clinical pharmacology.
2019 07; 59(7):979-988. doi:
10.1002/jcph.1388. [PMID: 30742306] - Christopher R Heier, Qing Yu, Alyson A Fiorillo, Christopher B Tully, Asya Tucker, Davi A Mazala, Kitipong Uaesoontrachoon, Sadish Srinivassane, Jesse M Damsker, Eric P Hoffman, Kanneboyina Nagaraju, Christopher F Spurney. Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy.
Life science alliance.
2019 02; 2(1):. doi:
10.26508/lsa.201800186. [PMID: 30745312] - Laurie S Conklin, Jesse M Damsker, Eric P Hoffman, William J Jusko, Panteleimon D Mavroudis, Benjamin D Schwartz, Laurel J Mengle-Gaw, Edward C Smith, Jean K Mah, Michela Guglieri, Yoram Nevo, Nancy Kuntz, Craig M McDonald, Mar Tulinius, Monique M Ryan, Richard Webster, Diana Castro, Richard S Finkel, Andrea L Smith, Lauren P Morgenroth, Adrienne Arrieta, Maya Shimony, Mark Jaros, Phil Shale, John M McCall, Yetrib Hathout, Kanneboyina Nagaraju, John van den Anker, Leanne M Ward, Alexandra Ahmet, Michaelyn R Cornish, Paula R Clemens. Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug.
Pharmacological research.
2018 10; 136(?):140-150. doi:
10.1016/j.phrs.2018.09.007. [PMID: 30219580] - Sen Chandra Sreetama, Goutam Chandra, Jack H Van der Meulen, Mohammad Mahad Ahmad, Peter Suzuki, Shivaprasad Bhuvanendran, Kanneboyina Nagaraju, Eric P Hoffman, Jyoti K Jaiswal. Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit.
Molecular therapy : the journal of the American Society of Gene Therapy.
2018 09; 26(9):2231-2242. doi:
10.1016/j.ymthe.2018.07.021. [PMID: 30166241] - Christopher R Heier, Jesse M Damsker, Qing Yu, Blythe C Dillingham, Tony Huynh, Jack H Van der Meulen, Arpana Sali, Brittany K Miller, Aditi Phadke, Luana Scheffer, James Quinn, Kathleen Tatem, Sarah Jordan, Sherry Dadgar, Olga C Rodriguez, Chris Albanese, Michael Calhoun, Heather Gordish-Dressman, Jyoti K Jaiswal, Edward M Connor, John M McCall, Eric P Hoffman, Erica K M Reeves, Kanneboyina Nagaraju. VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects.
EMBO molecular medicine.
2013 10; 5(10):1569-85. doi:
10.1002/emmm.201302621. [PMID: 24014378] - Erica K M Reeves, Eric P Hoffman, Kanneboyina Nagaraju, Jesse M Damsker, John M McCall. VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid.
Bioorganic & medicinal chemistry.
2013 Apr; 21(8):2241-2249. doi:
10.1016/j.bmc.2013.02.009. [PMID: 23498916]